EP4047019A4 - Anticorps anti-tslp et utilisations de celui-ci - Google Patents

Anticorps anti-tslp et utilisations de celui-ci Download PDF

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Publication number
EP4047019A4
EP4047019A4 EP20898089.6A EP20898089A EP4047019A4 EP 4047019 A4 EP4047019 A4 EP 4047019A4 EP 20898089 A EP20898089 A EP 20898089A EP 4047019 A4 EP4047019 A4 EP 4047019A4
Authority
EP
European Patent Office
Prior art keywords
tslp antibodies
tslp
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20898089.6A
Other languages
German (de)
English (en)
Other versions
EP4047019A1 (fr
Inventor
Liang Xiao
Jinqiu HE
Tongtong XUE
Hongshui LIU
Jingyi Wang
Hongzhuan GU
Shuntao LUO
Yiping Rong
Dengnian LIU
Yun He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Harbour Biomed Shanghai Co Ltd
Original Assignee
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Nona Biosciences Suzhou Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Kelun Biotech Biopharmaceutical Co Ltd, Nona Biosciences Suzhou Co Ltd filed Critical Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Publication of EP4047019A1 publication Critical patent/EP4047019A1/fr
Publication of EP4047019A4 publication Critical patent/EP4047019A4/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20898089.6A 2019-12-13 2020-12-08 Anticorps anti-tslp et utilisations de celui-ci Pending EP4047019A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911278628 2019-12-13
PCT/CN2020/134438 WO2021115240A1 (fr) 2019-12-13 2020-12-08 Anticorps anti-tslp et utilisations de celui-ci

Publications (2)

Publication Number Publication Date
EP4047019A1 EP4047019A1 (fr) 2022-08-24
EP4047019A4 true EP4047019A4 (fr) 2023-11-15

Family

ID=76328837

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20898089.6A Pending EP4047019A4 (fr) 2019-12-13 2020-12-08 Anticorps anti-tslp et utilisations de celui-ci

Country Status (10)

Country Link
US (1) US20220363781A1 (fr)
EP (1) EP4047019A4 (fr)
JP (2) JP7749549B2 (fr)
KR (1) KR20220113673A (fr)
CN (3) CN121851164A (fr)
AU (1) AU2020400221A1 (fr)
CA (1) CA3155759A1 (fr)
MX (1) MX2022004919A (fr)
TW (1) TWI851860B (fr)
WO (1) WO2021115240A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240052871A (ko) 2016-04-27 2024-04-23 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
WO2022100664A1 (fr) * 2020-11-12 2022-05-19 上海济煜医药科技有限公司 Protéine tslp de liaison à l'antigène et son utilisation
CN113501878B (zh) * 2021-02-03 2022-12-02 北京智仁美博生物科技有限公司 针对人tslp的多种抗体及其用途
CN113683694B (zh) 2021-09-03 2022-05-13 江苏荃信生物医药股份有限公司 一种抗人tslp单克隆抗体及其应用
US12110324B2 (en) 2022-07-22 2024-10-08 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP)
KR20250112240A (ko) * 2022-11-29 2025-07-23 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 B7-h3 결합 단백질 및 이의 용도
TW202448501A (zh) 2023-02-02 2024-12-16 美商麥迪紐有限責任公司 用抗ｔｓｌｐ抗體治療慢性鼻竇炎
EP4678659A1 (fr) 2023-02-23 2026-01-14 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Préparation d'anticorps monoclonaux ciblant la tslp
CN116675771B (zh) * 2023-03-01 2024-08-06 江苏荃信生物医药股份有限公司 一种抗人tslp单克隆抗体、包含其的试剂盒以及检查方法
KR20260013478A (ko) 2023-05-18 2026-01-28 메디뮨 엘엘씨 항-tslp 항체를 사용한 코르티코스테로이드 의존성 천식의 치료
AR134102A1 (es) * 2023-10-12 2025-12-03 Innovent Biologics Suzhou Co Ltd ANTICUERPOS ANTI-IL-4Ra Y USOS DE LOS MISMOS
CN117964755B (zh) * 2023-12-26 2025-01-21 华润生物医药有限公司 抗tslp抗体及其用途
WO2025147632A1 (fr) 2024-01-05 2025-07-10 Medimmune, Llc Traitement d'une broncho-pneumopathie chronique obstructive à l'aide d'un anticorps anti-tslp
WO2025163008A1 (fr) 2024-01-29 2025-08-07 Astrazeneca Ab Compositions de fragments de liaison à la lymphopoïétine stromale thymique (tslp), et leurs méthodes d'utilisation
WO2025214333A1 (fr) * 2024-04-08 2025-10-16 江苏恒瑞医药股份有限公司 Méthode de traitement d'une maladie inflammatoire associée à la tslp à l'aide d'un anticorps anti-tslp
WO2025221247A1 (fr) 2024-04-17 2025-10-23 Amgen Inc. Traitement de l'œsophagite à éosinophiles avec un anticorps anti-tslp
WO2025255558A2 (fr) * 2024-06-07 2025-12-11 Odyssey Therapeutics, Inc. Protéines de liaison à l'antigène anti-lymphopoïétine stromale thymique (tslp) et leurs utilisations
WO2026085414A1 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps se liant à tslp et anticorps se liant au récepteur alpha de l'interleukine 4 en combinaison avec de l'hyaluronidase ou un variant de celle-ci
WO2026085415A1 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps se liant à il-13 et anticorps se liant à tslp en combinaison avec de l'hyaluronidase ou un variant de celle-ci

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2007096149A1 (fr) * 2006-02-23 2007-08-30 Novartis Ag Composes organiques
WO2011056772A1 (fr) * 2009-11-04 2011-05-12 Schering Corporation Anticorps anti-tslp manufacturé
WO2017042701A1 (fr) * 2015-09-09 2017-03-16 Novartis Ag Anticorps de liaison à la lymphopoïétine stromale thymique (tslp) et méthodes d'utilisation des anticorps
WO2018191479A1 (fr) * 2017-04-12 2018-10-18 Amgen Inc. Traitement de l'asthme au moyen d'un anticorps anti-tslp

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KR20180042433A (ko) 2015-09-09 2018-04-25 노파르티스 아게 흉선 기질 림포포이에틴 (tslp)-결합 항체 및 항체의 사용 방법
CN115073581A (zh) * 2016-05-04 2022-09-20 美国安进公司 用于扩增t调节性细胞的白细胞介素-2突变蛋白
CA3103040A1 (fr) * 2018-05-11 2019-11-14 Wuxi Biologics (Shanghai) Co., Ltd. Anticorps entierement humains diriges contre ox40, procede de preparation correspondant, et utilisation associee
WO2020169755A2 (fr) * 2019-02-20 2020-08-27 Harbour Antibodies Bv Anticorps
EP3963055A1 (fr) * 2019-04-29 2022-03-09 Voyager Therapeutics, Inc. Anticorps vectorisés (vab) et leurs utilisations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007096149A1 (fr) * 2006-02-23 2007-08-30 Novartis Ag Composes organiques
WO2011056772A1 (fr) * 2009-11-04 2011-05-12 Schering Corporation Anticorps anti-tslp manufacturé
WO2017042701A1 (fr) * 2015-09-09 2017-03-16 Novartis Ag Anticorps de liaison à la lymphopoïétine stromale thymique (tslp) et méthodes d'utilisation des anticorps
WO2018191479A1 (fr) * 2017-04-12 2018-10-18 Amgen Inc. Traitement de l'asthme au moyen d'un anticorps anti-tslp

Non-Patent Citations (1)

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Title
See also references of WO2021115240A1 *

Also Published As

Publication number Publication date
CN114729037A (zh) 2022-07-08
CN121851164A (zh) 2026-04-14
CN121851165A (zh) 2026-04-14
CA3155759A1 (fr) 2021-06-17
CN114729037B (zh) 2026-02-06
TW202128753A (zh) 2021-08-01
EP4047019A1 (fr) 2022-08-24
JP2023505408A (ja) 2023-02-09
MX2022004919A (es) 2022-05-16
TWI851860B (zh) 2024-08-11
JP2026012690A (ja) 2026-01-27
WO2021115240A1 (fr) 2021-06-17
KR20220113673A (ko) 2022-08-16
AU2020400221A1 (en) 2022-05-19
US20220363781A1 (en) 2022-11-17
JP7749549B2 (ja) 2025-10-06

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