MA50144A - Anticorps anti-peptides bêta-amyloïdes n3pglu et utilisations associées - Google Patents

Anticorps anti-peptides bêta-amyloïdes n3pglu et utilisations associées

Info

Publication number
MA50144A
MA50144A MA050144A MA50144A MA50144A MA 50144 A MA50144 A MA 50144A MA 050144 A MA050144 A MA 050144A MA 50144 A MA50144 A MA 50144A MA 50144 A MA50144 A MA 50144A
Authority
MA
Morocco
Prior art keywords
n3pglu
peptid
beta
amyloid antibodies
associated uses
Prior art date
Application number
MA050144A
Other languages
English (en)
Inventor
Ronald Bradley Demattos
Jirong Lu
Ying Tang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA50144A publication Critical patent/MA50144A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA050144A 2017-04-20 2018-04-16 Anticorps anti-peptides bêta-amyloïdes n3pglu et utilisations associées MA50144A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762487550P 2017-04-20 2017-04-20

Publications (1)

Publication Number Publication Date
MA50144A true MA50144A (fr) 2020-07-29

Family

ID=62111232

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050144A MA50144A (fr) 2017-04-20 2018-04-16 Anticorps anti-peptides bêta-amyloïdes n3pglu et utilisations associées

Country Status (28)

Country Link
US (3) US10647759B2 (fr)
EP (1) EP3612559A1 (fr)
JP (3) JP6900500B2 (fr)
KR (2) KR102352670B1 (fr)
CN (2) CN110582511B (fr)
AR (1) AR111208A1 (fr)
AU (2) AU2018255221B2 (fr)
BR (1) BR112019018810A2 (fr)
CA (1) CA3058482C (fr)
CL (1) CL2019002922A1 (fr)
CO (1) CO2019011349A2 (fr)
CR (1) CR20190445A (fr)
DO (1) DOP2019000241A (fr)
EA (1) EA201992163A1 (fr)
EC (1) ECSP19075146A (fr)
IL (1) IL269003B2 (fr)
JO (1) JOP20190247A1 (fr)
MA (1) MA50144A (fr)
MX (2) MX2019012445A (fr)
NZ (1) NZ758066A (fr)
PE (1) PE20200011A1 (fr)
PH (1) PH12019502361A1 (fr)
SA (1) SA519410311B1 (fr)
SG (1) SG11201909022PA (fr)
TW (2) TWI789644B (fr)
UA (1) UA126806C2 (fr)
WO (1) WO2018194951A1 (fr)
ZA (2) ZA201906159B (fr)

Families Citing this family (29)

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TW201827467A (zh) 2016-11-03 2018-08-01 比利時商健生藥品公司 焦穀胺酸類澱粉蛋白－β之抗體及其用途
TWI789644B (zh) * 2017-04-20 2023-01-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途
SG11202110504XA (en) 2019-03-26 2021-10-28 Janssen Pharmaceutica Nv ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF
WO2021151011A2 (fr) * 2020-01-24 2021-07-29 The Board Of Trustees Of Western Michigan University Traitement de protéinopathies neurodégénératives à l'aide d'une molécule inhibitrice de l'apoptose fas (faim) ou d'un de ses fragments et/ou mimétiques
PE20231507A1 (es) * 2020-10-02 2023-09-26 Lilly Co Eli Metodos para reducir el contenido de proteinas de la celula huesped en procesos de purificacion de anticuerpos y composiciones de anticuerpos que tienen un contenido reducido de proteinas de la celula huesped
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
TW202300518A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
WO2022251048A1 (fr) 2021-05-24 2022-12-01 Eli Lilly And Company Anticorps anti-amyloïde bêta et leurs utilisations
JP7306746B2 (ja) * 2021-09-16 2023-07-11 株式会社ユニバーサルエンターテインメント 遊技機
JP7268910B2 (ja) * 2021-09-16 2023-05-08 株式会社ユニバーサルエンターテインメント 遊技機
JP7306745B2 (ja) * 2021-09-16 2023-07-11 株式会社ユニバーサルエンターテインメント 遊技機
MX2024004514A (es) * 2021-10-22 2024-05-07 Lilly Co Eli Terapia de combinacion con el inhibidor de o-glcnacasa (oga).
CA3236560A1 (fr) 2021-10-29 2023-05-04 Marcio Chedid Composes et procedes ciblant l'interleukine-34
MX2024005144A (es) 2021-10-29 2024-05-13 Lilly Co Eli Compuestos y metodos dirigidos a la interleucina-34.
US20260125460A1 (en) 2021-10-29 2026-05-07 Eli Lilly And Company Compounds and methods targeting interleukin-34
IL312380A (en) 2021-10-29 2024-06-01 Lilly Co Eli Compounds and methods targeting interleukin-34
CA3243602A1 (fr) 2022-02-03 2023-08-10 Eli Lilly And Company Imagerie de tau régionale pour le diagnostic et le traitement de la maladie d'alzheimer
CN117327168B (zh) * 2022-06-24 2026-06-19 厦门大学 B2M-GluN1封闭肽、其药物组合物及用途
CN120583962A (zh) * 2022-11-17 2025-09-02 伊莱利利公司 抗N3pGluβ淀粉样蛋白抗体、其剂量及其用途
WO2024133925A1 (fr) 2022-12-22 2024-06-27 Bioarctic Ab Anticorps se liant à abêtape3
IL328051A (en) 2023-11-14 2026-06-01 Lilly Co Eli Fc RECEPTOR BASED ASSAYS FOR ANALYZING IgG ANTIBODIES
WO2025228316A1 (fr) * 2024-04-28 2025-11-06 Jacobio Pharmaceuticals Co., Ltd. Anticorps anti-bêta-amyloïdes n3pglu et leurs utilisations
WO2025255300A1 (fr) * 2024-06-06 2025-12-11 Eli Lilly And Company Formulations pour anticorps anti-n3pglu amyloïde bêta
WO2025262228A1 (fr) 2024-06-20 2025-12-26 Bioarctic Ab Molécule de liaison bispécifique
CN118459583B (zh) * 2024-07-11 2024-09-10 齐鲁制药有限公司 抗N3pGlu淀粉样蛋白β抗体及其用途
WO2026012421A1 (fr) * 2024-07-11 2026-01-15 齐鲁制药有限公司 ANTICORPS β-AMYLOÏDE ANTI-N3PGLU ET SON UTILISATION
WO2026075947A1 (fr) 2024-10-01 2026-04-09 Eli Lilly And Company Régimes posologiques pour la maladie d'alzheimer précoce
WO2026122407A1 (fr) * 2024-12-04 2026-06-11 Merck Sharp & Dohme Llc Agent de liaison de bêta amyloïde et utilisations associées

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EA006606B1 (ru) * 2000-02-24 2006-02-24 Вашингтон Юниверсити Гуманизированное антитело и его фрагмент, взаимодействующие с бета-амилоидным пептидом, и способы их применения
US6815175B2 (en) * 2001-03-16 2004-11-09 Cornell Research Foundation, Inc. Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
US7122374B1 (en) 2002-04-09 2006-10-17 Takaomi Saido Amyloid beta-protein 3(pE)-42 antibodies and uses thereof
WO2004013172A2 (fr) 2002-07-24 2004-02-12 Innogenetics N.V. Prevention, traitement et diagnostic de maladies associees a la formation et/ou a l'agregation de la beta-amyloide
CA2538220A1 (fr) 2003-09-09 2005-03-24 Takeda Pharmaceutical Company Limited Utilisation d'un anticorps
AU2005290250A1 (en) 2004-07-30 2006-04-06 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
PE20061323A1 (es) * 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
RU2498999C2 (ru) 2006-07-14 2013-11-20 Ац Иммуне Са Гуманизированное антитело к амилоиду бета
CA2723995A1 (fr) 2008-06-12 2009-12-17 Affiris Ag Composes destines au traitement de symptomes associes a la maladie de parkinson
WO2010004434A2 (fr) 2008-07-09 2010-01-14 University Of Zurich Procédé d'activation de la neurogenèse
KR101706789B1 (ko) 2008-07-21 2017-02-14 프로비오드룩 아게 진단용 항체 검사법
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
WO2012021475A2 (fr) * 2010-08-12 2012-02-16 Eli Lilly And Company ANTICORPS CONTRE LE PEPTIDE N3pGLU AMYLOÏDE BÊTA ET LEURS UTILISATIONS
SI3339323T1 (sl) * 2010-08-12 2019-12-31 Eli Lilly And Company Protitelesa proti N3PGLU amiloid beta peptidu in njihove uporabe
WO2015175769A1 (fr) * 2014-05-15 2015-11-19 Biogen Ma Inc. Procédés de détection d'oligomères bêta-amyloïdes dans des échantillons biologiques
TWI599358B (zh) * 2014-09-16 2017-09-21 美國禮來大藥廠 組合療法
HUE057285T2 (hu) * 2015-04-13 2022-04-28 Pfizer Terápiás ellenanyagok és alkalmazásaik
JOP20170004B1 (ar) * 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TWI735600B (zh) * 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途
TWI789644B (zh) * 2017-04-20 2023-01-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途

Also Published As

Publication number Publication date
CN117024583A (zh) 2023-11-10
US20210371509A1 (en) 2021-12-02
NZ758066A (en) 2022-10-28
WO2018194951A1 (fr) 2018-10-25
CA3058482A1 (fr) 2018-10-25
US11078261B2 (en) 2021-08-03
MX2022011817A (es) 2022-10-10
TWI789644B (zh) 2023-01-11
TWI705975B (zh) 2020-10-01
AU2018255221A1 (en) 2019-09-19
ECSP19075146A (es) 2019-10-31
ZA202007868B (en) 2023-06-28
US10647759B2 (en) 2020-05-12
JP6900500B2 (ja) 2021-07-07
AU2021203927A1 (en) 2021-07-08
ZA201906159B (en) 2026-03-25
DOP2019000241A (es) 2019-10-15
CO2019011349A2 (es) 2019-10-31
KR102567295B1 (ko) 2023-08-16
TW202120541A (zh) 2021-06-01
CL2019002922A1 (es) 2020-03-13
KR20220011800A (ko) 2022-01-28
AU2018255221B2 (en) 2021-07-01
BR112019018810A2 (pt) 2020-05-05
KR102352670B1 (ko) 2022-01-19
KR20190129100A (ko) 2019-11-19
CN110582511A (zh) 2019-12-17
EP3612559A1 (fr) 2020-02-26
JP2021151253A (ja) 2021-09-30
US20180305444A1 (en) 2018-10-25
SA519410311B1 (ar) 2022-03-20
PH12019502361A1 (en) 2020-07-13
UA126806C2 (uk) 2023-02-08
AU2021203927B2 (en) 2024-03-21
IL269003B1 (en) 2025-06-01
SG11201909022PA (en) 2019-11-28
JOP20190247A1 (ar) 2019-10-20
MX2019012445A (es) 2020-01-13
IL269003B2 (en) 2025-10-01
IL269003A (en) 2019-10-31
EA201992163A1 (ru) 2020-03-02
JP7227312B2 (ja) 2023-02-21
JP7532571B2 (ja) 2024-08-13
JP2023058623A (ja) 2023-04-25
AR111208A1 (es) 2019-06-12
CN110582511B (zh) 2023-08-08
CR20190445A (es) 2019-11-06
CA3058482C (fr) 2023-05-09
JP2020510081A (ja) 2020-04-02
US20200262902A1 (en) 2020-08-20
TW201902924A (zh) 2019-01-16
PE20200011A1 (es) 2020-01-06

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