EP4272837A3 - Cellules car-t ciblant bcma pour le traitement de myélomes multiples - Google Patents

Cellules car-t ciblant bcma pour le traitement de myélomes multiples Download PDF

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Publication number
EP4272837A3
EP4272837A3 EP23190869.0A EP23190869A EP4272837A3 EP 4272837 A3 EP4272837 A3 EP 4272837A3 EP 23190869 A EP23190869 A EP 23190869A EP 4272837 A3 EP4272837 A3 EP 4272837A3
Authority
EP
European Patent Office
Prior art keywords
car
treatment
multiple myeloma
cells against
against bcma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23190869.0A
Other languages
German (de)
English (en)
Other versions
EP4272837A2 (fr
Inventor
Álvaro URBANO ISPIZUA
Beatriz MARTÍN ANTONIO
Lorena PÉREZ AMILL
Guillermo SUÑE RODRIGUEZ
Manel JUAN OTERO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat de Barcelona
Hospital Clínic de Barcelona
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Original Assignee
Universitat de Barcelona
Hospital Clínic de Barcelona
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat de Barcelona, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer filed Critical Universitat de Barcelona
Publication of EP4272837A2 publication Critical patent/EP4272837A2/fr
Publication of EP4272837A3 publication Critical patent/EP4272837A3/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
EP23190869.0A 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples Pending EP4272837A3 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382673 2019-08-02
EP20757544.0A EP4007777B1 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples
PCT/EP2020/071831 WO2021023721A1 (fr) 2019-08-02 2020-08-03 Lymphocytes t car dirigés contre bcma pour le traitement du myélome multiple

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP20757544.0A Division-Into EP4007777B1 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples
EP20757544.0A Division EP4007777B1 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples

Publications (2)

Publication Number Publication Date
EP4272837A2 EP4272837A2 (fr) 2023-11-08
EP4272837A3 true EP4272837A3 (fr) 2024-02-28

Family

ID=67658496

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23190869.0A Pending EP4272837A3 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples
EP20757544.0A Active EP4007777B1 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20757544.0A Active EP4007777B1 (fr) 2019-08-02 2020-08-03 Cellules car-t ciblant bcma pour le traitement de myélomes multiples

Country Status (18)

Country Link
US (1) US12509525B2 (fr)
EP (2) EP4272837A3 (fr)
JP (1) JP7729561B2 (fr)
AU (1) AU2020325690A1 (fr)
CA (1) CA3148930A1 (fr)
DK (1) DK4007777T5 (fr)
ES (1) ES2971033T3 (fr)
FI (1) FI4007777T3 (fr)
HR (1) HRP20240037T1 (fr)
HU (1) HUE064890T2 (fr)
LT (1) LT4007777T (fr)
PL (1) PL4007777T3 (fr)
PT (1) PT4007777T (fr)
RS (1) RS65094B1 (fr)
SI (1) SI4007777T1 (fr)
SM (1) SMT202400013T1 (fr)
WO (1) WO2021023721A1 (fr)
ZA (1) ZA202201166B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4475896A1 (fr) * 2022-02-09 2024-12-18 Hadasit Medical Research Services&Development Ltd. Car anti-bcma pour cibler des troubles liés à l'immunité, compositions et méthodes associées
EP4378953A1 (fr) * 2022-12-02 2024-06-05 Universitat de Barcelona Fraction de ciblage de cd29 pour le traitement du cancer positif de cd29
WO2025141187A1 (fr) * 2023-12-29 2025-07-03 Fundación Para La Investigación Biomédica Del Hospital Universitario 12 De Octubre Lymphocytes t exprimant des anticorps bispécifiques anti-bcma/anti-cd3 et leurs utilisations
CN122140960B (zh) * 2026-05-11 2026-08-11 重庆医科大学附属第一医院 一种双适配体修饰的膜融合脂质体及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017211900A1 (fr) * 2016-06-07 2017-12-14 Max-Delbrück-Centrum für Molekulare Medizin Récepteur d'antigène chimère et cellules t-car se liant à bcma
CN108004259A (zh) * 2016-11-02 2018-05-08 上海恒润达生生物科技有限公司 靶向b细胞成熟抗原的嵌合抗原受体及其用途
CN108285489A (zh) * 2017-01-09 2018-07-17 上海恒润达生生物科技有限公司 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途
CN108395478A (zh) * 2017-02-04 2018-08-14 上海恒润达生生物科技有限公司 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途
US20180325955A1 (en) * 2017-05-12 2018-11-15 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology

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DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
DE69233697T2 (de) 1991-03-01 2008-01-24 Dyax Corp., Cambridge Verfahren zur Entwicklung von bindenden Mikroproteinen
PT100379B (pt) 1991-04-10 1999-01-29 Scripps Research Inst Bibliotecas de receptores heterodimericos usando fagomideos
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
AU6827094A (en) 1993-05-07 1994-12-12 Immunex Corporation Cytokine designated 4-1bb ligand and human receptor that binds thereto
NO3051026T3 (fr) 2011-10-21 2018-07-28
EP2914628A1 (fr) * 2012-11-01 2015-09-09 Max-Delbrück-Centrum für Molekulare Medizin Anticorps qui se lie à cd269 (bcma) pouvant être utilisé dans le traitement de maladies des cellules plasmatiques comme le myélome multiple et les maladies auto-immunes
ES2546743B1 (es) 2014-03-28 2016-07-07 Institut D'investigació Biomèdica De Bellvitge (Idibell) Marcadores mitocondriales de enfermedades neurodegenerativas
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WO2017211900A1 (fr) * 2016-06-07 2017-12-14 Max-Delbrück-Centrum für Molekulare Medizin Récepteur d'antigène chimère et cellules t-car se liant à bcma
CN108004259A (zh) * 2016-11-02 2018-05-08 上海恒润达生生物科技有限公司 靶向b细胞成熟抗原的嵌合抗原受体及其用途
CN108285489A (zh) * 2017-01-09 2018-07-17 上海恒润达生生物科技有限公司 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途
CN108395478A (zh) * 2017-02-04 2018-08-14 上海恒润达生生物科技有限公司 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途
US20180325955A1 (en) * 2017-05-12 2018-11-15 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology

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MARINA MARTINEZ ET AL: "CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment", FRONTIERS IN IMMUNOLOGY, vol. 10, 5 February 2019 (2019-02-05), pages 12800128, XP055727858, DOI: 10.3389/fimmu.2019.00128 *

Also Published As

Publication number Publication date
PL4007777T3 (pl) 2024-03-11
SMT202400013T1 (it) 2024-03-13
EP4007777A1 (fr) 2022-06-08
EP4007777B1 (fr) 2023-10-11
EP4272837A2 (fr) 2023-11-08
JP7729561B2 (ja) 2025-08-26
HRP20240037T1 (hr) 2024-03-29
LT4007777T (lt) 2024-02-12
PT4007777T (pt) 2024-01-12
SI4007777T1 (sl) 2024-03-29
AU2020325690A1 (en) 2022-03-03
ES2971033T3 (es) 2024-06-03
ZA202201166B (en) 2022-10-26
WO2021023721A1 (fr) 2021-02-11
US12509525B2 (en) 2025-12-30
CA3148930A1 (fr) 2021-02-11
DK4007777T5 (da) 2024-08-05
RS65094B1 (sr) 2024-02-29
US20220267459A1 (en) 2022-08-25
DK4007777T3 (da) 2024-01-15
HUE064890T2 (hu) 2024-04-28
JP2022542443A (ja) 2022-10-03
FI4007777T3 (fi) 2024-01-11

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