EP4334338A4 - Molekularer entwurf von glucosesensoren in auf glucose reagierenden insulinanaloga - Google Patents

Molekularer entwurf von glucosesensoren in auf glucose reagierenden insulinanaloga

Info

Publication number
EP4334338A4
EP4334338A4 EP22799444.9A EP22799444A EP4334338A4 EP 4334338 A4 EP4334338 A4 EP 4334338A4 EP 22799444 A EP22799444 A EP 22799444A EP 4334338 A4 EP4334338 A4 EP 4334338A4
Authority
EP
European Patent Office
Prior art keywords
glucose
insulin analogues
molecular design
sensitive insulin
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP22799444.9A
Other languages
English (en)
French (fr)
Other versions
EP4334338A1 (de
Inventor
Michael A. Weiss
Mark A. Jarosinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University (System)
Indiana University Bloomington
Original Assignee
Indiana University (System)
Indiana University Bloomington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University (System), Indiana University Bloomington filed Critical Indiana University (System)
Publication of EP4334338A1 publication Critical patent/EP4334338A1/de
Publication of EP4334338A4 publication Critical patent/EP4334338A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP22799444.9A 2021-05-03 2022-05-03 Molekularer entwurf von glucosesensoren in auf glucose reagierenden insulinanaloga Withdrawn EP4334338A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163183325P 2021-05-03 2021-05-03
PCT/US2022/027504 WO2022235691A1 (en) 2021-05-03 2022-05-03 Molecular design of glucose sensors in glucose-responsive insulin analogues

Publications (2)

Publication Number Publication Date
EP4334338A1 EP4334338A1 (de) 2024-03-13
EP4334338A4 true EP4334338A4 (de) 2025-06-18

Family

ID=83932434

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22799444.9A Withdrawn EP4334338A4 (de) 2021-05-03 2022-05-03 Molekularer entwurf von glucosesensoren in auf glucose reagierenden insulinanaloga

Country Status (3)

Country Link
EP (1) EP4334338A4 (de)
CN (1) CN117337299A (de)
WO (1) WO2022235691A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3199254A1 (en) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
PE20251287A1 (es) * 2022-05-18 2025-05-14 Protomer Tech Inc Compuestos aromaticos que contienen boro y analogos de insulina relacionados
CN122055379A (zh) * 2023-04-11 2026-05-15 普罗托莫科技公司 含有一个或多个二硼酸酯的化合物及相关胰岛素类似物
WO2025096528A1 (en) * 2023-10-30 2025-05-08 The Trustees Of Indiana University Cooperative glucose-binding element based glucose-responsive insulins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149222A2 (en) * 2015-03-13 2016-09-22 Case Western Reserve University Insulin analogues containing a glucose-regulated conformational switch
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
WO2020214955A1 (en) * 2019-04-19 2020-10-22 The Trustees Of Indiana University Stabilization of prandial or basal insulin analogues by an internal diselenide bridge

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12011502708B1 (en) * 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
MA50552A (fr) * 2017-11-09 2020-09-16 Novo Nordisk As Dérivés de liaison à l'albumine sensibles au glucose

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149222A2 (en) * 2015-03-13 2016-09-22 Case Western Reserve University Insulin analogues containing a glucose-regulated conformational switch
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
WO2020214955A1 (en) * 2019-04-19 2020-10-22 The Trustees Of Indiana University Stabilization of prandial or basal insulin analogues by an internal diselenide bridge

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAROSINSKI MARK A ET AL: "'Smart' insulin-delivery technologies and intrinsic glucose-responsive insulin analogues", DIABETOLOGIA, vol. 64, no. 5, 12 March 2021 (2021-03-12), pages 1016 - 1029, XP037394114, ISSN: 0012-186X, DOI: 10.1007/S00125-021-05422-6 *
See also references of WO2022235691A1 *
WAYNE D. KOHN ET AL: "pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity", PEPTIDES, vol. 28, no. 4, 1 April 2007 (2007-04-01), pages 935 - 948, XP055017239, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2007.01.012 *

Also Published As

Publication number Publication date
WO2022235691A1 (en) 2022-11-10
EP4334338A1 (de) 2024-03-13
CN117337299A (zh) 2024-01-02

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