EP4334338A4 - Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose - Google Patents

Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose

Info

Publication number
EP4334338A4
EP4334338A4 EP22799444.9A EP22799444A EP4334338A4 EP 4334338 A4 EP4334338 A4 EP 4334338A4 EP 22799444 A EP22799444 A EP 22799444A EP 4334338 A4 EP4334338 A4 EP 4334338A4
Authority
EP
European Patent Office
Prior art keywords
glucose
insulin analogues
molecular design
sensitive insulin
sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP22799444.9A
Other languages
German (de)
English (en)
Other versions
EP4334338A1 (fr
Inventor
Michael A. Weiss
Mark A. Jarosinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University (System)
Indiana University Bloomington
Original Assignee
Indiana University (System)
Indiana University Bloomington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University (System), Indiana University Bloomington filed Critical Indiana University (System)
Publication of EP4334338A1 publication Critical patent/EP4334338A1/fr
Publication of EP4334338A4 publication Critical patent/EP4334338A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP22799444.9A 2021-05-03 2022-05-03 Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose Withdrawn EP4334338A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163183325P 2021-05-03 2021-05-03
PCT/US2022/027504 WO2022235691A1 (fr) 2021-05-03 2022-05-03 Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose

Publications (2)

Publication Number Publication Date
EP4334338A1 EP4334338A1 (fr) 2024-03-13
EP4334338A4 true EP4334338A4 (fr) 2025-06-18

Family

ID=83932434

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22799444.9A Withdrawn EP4334338A4 (fr) 2021-05-03 2022-05-03 Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose

Country Status (3)

Country Link
EP (1) EP4334338A4 (fr)
CN (1) CN117337299A (fr)
WO (1) WO2022235691A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3199254A1 (fr) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Conceptions moleculaires d'analogues d'insuline sensibles au glucose et clivables par le glucose
PE20251287A1 (es) * 2022-05-18 2025-05-14 Protomer Tech Inc Compuestos aromaticos que contienen boro y analogos de insulina relacionados
CN122055379A (zh) * 2023-04-11 2026-05-15 普罗托莫科技公司 含有一个或多个二硼酸酯的化合物及相关胰岛素类似物
WO2025096528A1 (fr) * 2023-10-30 2025-05-08 The Trustees Of Indiana University Insulines sensibles au glucose à base d'élément de liaison au glucose coopératif

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149222A2 (fr) * 2015-03-13 2016-09-22 Case Western Reserve University Analogues de l'insuline contenant un commutateur de conformation régulé par le glucose
WO2017070617A1 (fr) * 2015-10-21 2017-04-27 Case Western Reserve University Analogues de l'insuline modifiés avec un diol contenant un commutateur de conformation régulé par le glucose
WO2020214955A1 (fr) * 2019-04-19 2020-10-22 The Trustees Of Indiana University Stabilisation d'analogues d'insuline prandiale ou basale par un pont diséléniure interne

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12011502708B1 (en) * 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
MA50552A (fr) * 2017-11-09 2020-09-16 Novo Nordisk As Dérivés de liaison à l'albumine sensibles au glucose

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149222A2 (fr) * 2015-03-13 2016-09-22 Case Western Reserve University Analogues de l'insuline contenant un commutateur de conformation régulé par le glucose
WO2017070617A1 (fr) * 2015-10-21 2017-04-27 Case Western Reserve University Analogues de l'insuline modifiés avec un diol contenant un commutateur de conformation régulé par le glucose
WO2020214955A1 (fr) * 2019-04-19 2020-10-22 The Trustees Of Indiana University Stabilisation d'analogues d'insuline prandiale ou basale par un pont diséléniure interne

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAROSINSKI MARK A ET AL: "'Smart' insulin-delivery technologies and intrinsic glucose-responsive insulin analogues", DIABETOLOGIA, vol. 64, no. 5, 12 March 2021 (2021-03-12), pages 1016 - 1029, XP037394114, ISSN: 0012-186X, DOI: 10.1007/S00125-021-05422-6 *
See also references of WO2022235691A1 *
WAYNE D. KOHN ET AL: "pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity", PEPTIDES, vol. 28, no. 4, 1 April 2007 (2007-04-01), pages 935 - 948, XP055017239, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2007.01.012 *

Also Published As

Publication number Publication date
WO2022235691A1 (fr) 2022-11-10
EP4334338A1 (fr) 2024-03-13
CN117337299A (zh) 2024-01-02

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