EP4363616A4 - Détection de perte d'hétérozygotie de l'antigène leucocytaire humain - Google Patents

Détection de perte d'hétérozygotie de l'antigène leucocytaire humain

Info

Publication number
EP4363616A4
EP4363616A4 EP21948675.0A EP21948675A EP4363616A4 EP 4363616 A4 EP4363616 A4 EP 4363616A4 EP 21948675 A EP21948675 A EP 21948675A EP 4363616 A4 EP4363616 A4 EP 4363616A4
Authority
EP
European Patent Office
Prior art keywords
heterozygosy
leukocy
antigen
loss
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21948675.0A
Other languages
German (de)
English (en)
Other versions
EP4363616A1 (fr
Inventor
Ariane Lozac'hmeur
Jason PERERA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tempus AI Inc
Original Assignee
Tempus AI Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/304,940 external-priority patent/US11475978B2/en
Application filed by Tempus AI Inc filed Critical Tempus AI Inc
Publication of EP4363616A1 publication Critical patent/EP4363616A1/fr
Publication of EP4363616A4 publication Critical patent/EP4363616A4/fr
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Evolutionary Computation (AREA)
  • Microbiology (AREA)
  • Software Systems (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioethics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP21948675.0A 2021-06-28 2021-07-16 Détection de perte d'hétérozygotie de l'antigène leucocytaire humain Pending EP4363616A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/304,940 US11475978B2 (en) 2019-02-12 2021-06-28 Detection of human leukocyte antigen loss of heterozygosity
PCT/US2021/042039 WO2023277932A1 (fr) 2021-06-28 2021-07-16 Détection de perte d'hétérozygotie de l'antigène leucocytaire humain

Publications (2)

Publication Number Publication Date
EP4363616A1 EP4363616A1 (fr) 2024-05-08
EP4363616A4 true EP4363616A4 (fr) 2025-04-30

Family

ID=84690558

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21948675.0A Pending EP4363616A4 (fr) 2021-06-28 2021-07-16 Détection de perte d'hétérozygotie de l'antigène leucocytaire humain

Country Status (4)

Country Link
EP (1) EP4363616A4 (fr)
AU (1) AU2021454223A1 (fr)
CA (1) CA3219608A1 (fr)
WO (1) WO2023277932A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116612808B (zh) * 2023-05-05 2025-11-25 成都爱诺言医学检验实验室有限公司 基于ngs技术的hiv-1耐药基因检测方法
CN117409868B (zh) * 2023-12-14 2024-02-20 成都大熊猫繁育研究基地 一种大熊猫遗传图谱绘制方法和系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130203A1 (fr) * 2019-02-12 2020-08-20 Tempus Labs, Inc. Detection de perte d'heterozygotie de l'antigene leucocytaire humain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014116729A2 (fr) * 2013-01-22 2014-07-31 The Board Of Trustees Of The Leland Stanford Junior University Haplotypage de loci hla par séquençage ultra-profond à l'aveugle
EP3651791A1 (fr) * 2017-07-14 2020-05-20 The Francis Crick Institute Limited Analyse d'allèles hla dans des tumeurs et utilisations associées

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130203A1 (fr) * 2019-02-12 2020-08-20 Tempus Labs, Inc. Detection de perte d'heterozygotie de l'antigene leucocytaire humain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NICHOLAS MCGRANAHAN ET AL: "Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution", CELL, vol. 171, no. 6, 1 November 2017 (2017-11-01), Amsterdam NL, pages 1259 - 1271.e11, XP055547263, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.10.001 *
See also references of WO2023277932A1 *
WATKINS THOMAS B K ET AL: "Pervasive chromosomal instability and karyotype order in tumour evolution", NATURE,, vol. 587, no. 7832, 2 September 2020 (2020-09-02), pages 126 - 132, XP037295102, DOI: 10.1038/S41586-020-2698-6 *

Also Published As

Publication number Publication date
EP4363616A1 (fr) 2024-05-08
CA3219608A1 (fr) 2023-01-08
WO2023277932A1 (fr) 2023-01-05
AU2021454223A1 (en) 2024-01-18

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