MA54615A - Anticorps monoclonal contre le récepteur alpha de l'interleukine-4 humaine et son utilisation - Google Patents

Anticorps monoclonal contre le récepteur alpha de l'interleukine-4 humaine et son utilisation

Info

Publication number
MA54615A
MA54615A MA054615A MA54615A MA54615A MA 54615 A MA54615 A MA 54615A MA 054615 A MA054615 A MA 054615A MA 54615 A MA54615 A MA 54615A MA 54615 A MA54615 A MA 54615A
Authority
MA
Morocco
Prior art keywords
monoclonal antibody
antibody against
against human
human interleukin
alpha receptor
Prior art date
Application number
MA054615A
Other languages
English (en)
Inventor
Wei Chen
Huaiyao Qiao
Jiwan Qiu
Zhihua Qiu
Yiliang Wu
Original Assignee
Qyuns Therapeutics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qyuns Therapeutics Co Ltd filed Critical Qyuns Therapeutics Co Ltd
Publication of MA54615A publication Critical patent/MA54615A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA054615A 2018-12-25 2019-12-25 Anticorps monoclonal contre le récepteur alpha de l'interleukine-4 humaine et son utilisation MA54615A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811592427.XA CN110746507B (zh) 2018-12-25 2018-12-25 抗人白介素4受体α单克隆抗体及其应用

Publications (1)

Publication Number Publication Date
MA54615A true MA54615A (fr) 2021-11-03

Family

ID=69275667

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054615A MA54615A (fr) 2018-12-25 2019-12-25 Anticorps monoclonal contre le récepteur alpha de l'interleukine-4 humaine et son utilisation

Country Status (8)

Country Link
US (1) US12297280B2 (fr)
EP (1) EP3902837B1 (fr)
JP (1) JP7118480B2 (fr)
CN (5) CN111494625B (fr)
AU (1) AU2019416486B2 (fr)
CA (1) CA3124726A1 (fr)
MA (1) MA54615A (fr)
WO (1) WO2020135471A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111494625B (zh) * 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物
CN113527485B (zh) * 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN113549151A (zh) * 2020-04-24 2021-10-26 苏州康乃德生物医药有限公司 与人IL-4Rα中特定表位结合的抗体及其应用
CN114605539B (zh) * 2020-12-09 2024-01-02 南京融捷康生物科技有限公司 人源化的抗IL-4Rα单域抗体及其应用
EP4019547A1 (fr) * 2020-12-23 2022-06-29 Numab Therapeutics AG Anticorps multispécifiques ayant une spécificité pour il-4r et il-31
EP4019090A1 (fr) * 2020-12-23 2022-06-29 Numab Therapeutics AG Domaines variables d'anticorps liant il-4r
JP7846119B2 (ja) * 2020-12-23 2026-04-14 ヌマブ セラピューティクス アクチェンゲゼルシャフト Ｉｌ－４ｒに結合する抗体可変ドメイン
EP4019546A1 (fr) * 2020-12-23 2022-06-29 Numab Therapeutics AG Domaines variables d'anticorps qui se lient à il-31
TWI876192B (zh) * 2021-08-05 2025-03-11 美商美國禮來大藥廠 人類介白素-4受體α抗體
IL316264A (en) 2022-05-02 2024-12-01 Regeneron Pharma Antibody formulations against interleukin-4 receptor (IL-4R)
WO2023215750A2 (fr) 2022-05-02 2023-11-09 Regeneron Pharmaceuticals, Inc. Procédés de réduction de l'activité de lipase
CN115960236B (zh) * 2023-01-05 2024-08-06 江苏荃信生物医药股份有限公司 一种定量检测血清中抗人白介素4受体α单克隆抗体含量的酶联免疫分析方法
AU2024373307A1 (en) 2023-11-02 2026-05-14 Regeneron Pharmaceuticals, Inc. Methods for reducing lipase activity using stress
TW202607027A (zh) 2024-04-15 2026-02-16 法商賽諾菲生物技術公司 藉由施用ｉｌ－４ｒ拮抗劑治療慢性鼻竇炎不伴鼻息肉之方法
US20260070995A1 (en) 2024-09-09 2026-03-12 Marcella Ruddy Methods for treating bullous pemphigoid by administering an il-4r antagonist
WO2026059949A1 (fr) 2024-09-10 2026-03-19 Sanofi Biotechnology Méthodes de traitement du prurit chronique d'origine inconnue (cpuo) par administration d'un antagoniste d'il-4r

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (fr) * 1992-12-29 1994-07-06 Schering-Plough Anticorps monoclonaux contre le récepteur de l'interleukine-4 humain et hydridomes les produisant
US6846486B1 (en) 2000-02-24 2005-01-25 Advanced Biotherapy Concepts, Inc. Method of treating allergy by administering an anti-histamine antibody
WO2001092340A2 (fr) 2000-05-26 2001-12-06 Immunex Corporation Utilisation d'antagonistes vis-a-vis de l'interleukine-4 (il-4) et compositions correspondantes
NZ547588A (en) 2003-11-07 2009-05-31 Immunex Corp Antibodies that bind interleukin-4 receptor
TW200804593A (en) 2006-01-24 2008-01-16 Domantis Ltd Fusion proteins that contain natural junctions
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
LT2769992T (lt) * 2006-10-02 2021-04-12 Regeneron Pharmaceuticals, Inc. Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių
EP2125037A2 (fr) 2006-12-15 2009-12-02 Centocor Ortho Biotech, Inc. Méthodes et compositions destinées à traiter des pathologies associées à la fibrose liée à l'il-4 ou à l'il-13
EP2050764A1 (fr) * 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
DK2245064T3 (da) * 2007-12-21 2014-10-27 Medimmune Ltd BINDINGSELEMENTER TIL INTERLEUKIN-4-RECEPTOR-ALFA (IL-4Ralfa)
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
WO2009114828A1 (fr) 2008-03-13 2009-09-17 Childrens Hospital Medical Center Compositions et procédés relatifs à des états d’allergie gastro-intestinale
JP6161233B2 (ja) 2008-03-31 2017-07-12 ジェネンテック， インコーポレイテッド 喘息の治療及び診断のための組成物及び方法
WO2009121847A2 (fr) 2008-04-02 2009-10-08 Apogenix Gmbh Agents de liaison dirigés contre le récepteur de il-4 pour le traitement de tumeurs, de troubles inflammatoires et de troubles immunologiques
CA2743394C (fr) * 2008-11-17 2018-01-02 Koebenhavns Universitet Peptides derives d'il-4 pour la modulation de la reponse inflammatoire chronique et le traitement de maladies auto-immunes
WO2013087660A1 (fr) 2011-12-13 2013-06-20 Pieris Ag Méthodes de prévention ou de traitement de certains troubles par l'inhibition de la liaison d'il-4 et/ou il-13 à leurs récepteurs respectifs
EP2791171A1 (fr) 2011-12-16 2014-10-22 Synthon Biopharmaceuticals B.V. Expression d'anticorps iga sécrétoires chez la lentille d'eau
IL312711A (en) * 2012-08-21 2024-07-01 Regeneron Pharma Methods for the treatment or prevention of asthma through the administration of an antagonist to 4R-IL
KR102284244B1 (ko) * 2012-09-07 2021-08-03 리제너론 파아마슈티컬스, 인크. Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법
KR102576903B1 (ko) * 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법
HK1220919A1 (zh) 2013-04-05 2017-05-19 F. Hoffmann-La Roche Ag 抗il-4抗体和双特异性抗体及其用途
TWI755763B (zh) * 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
KR20210132232A (ko) 2013-06-21 2021-11-03 사노피 바이오테크놀로지 Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
KR102927870B1 (ko) 2014-02-28 2026-02-19 리제너론 파아마슈티컬스, 인크. Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법
AU2015310879A1 (en) * 2014-09-03 2017-03-02 Medimmune Limited Stable anti-IL-4R-alpha antibody formulation
WO2016077675A1 (fr) 2014-11-14 2016-05-19 Sanofi Biotechnology Méthodes de traitement de la sinusite chronique avec polypose nasale par administration d'un antagoniste d'il-4r
CN113372446A (zh) 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
US11771743B2 (en) 2016-09-01 2023-10-03 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an IL-4R antagonist
KR20190053250A (ko) * 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
CN108409860B (zh) * 2017-02-10 2021-10-15 三生国健药业（上海）股份有限公司 抗人白细胞介素-4受体α单克隆抗体、其制备方法和应用
WO2019028367A1 (fr) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de l'oesophagite à éosinophiles active
CN108373505B (zh) * 2018-04-20 2019-08-20 北京智仁美博生物科技有限公司 抗il-4r抗体及其用途
CN108640991B (zh) * 2018-05-17 2019-09-27 江苏荃信生物医药有限公司 抗人白介素17a单克隆抗体及其应用
CN111494625B (zh) * 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物

Also Published As

Publication number Publication date
AU2019416486A1 (en) 2021-07-08
CN111494626B (zh) 2022-06-21
CN111494625B (zh) 2022-06-21
EP3902837B1 (fr) 2025-03-05
JP2022516483A (ja) 2022-02-28
CN111494625A (zh) 2020-08-07
CN110746507A (zh) 2020-02-04
WO2020135471A1 (fr) 2020-07-02
CN111518211A (zh) 2020-08-11
US20220073631A1 (en) 2022-03-10
JP7118480B2 (ja) 2022-08-16
CN111514292A (zh) 2020-08-11
CN111494626A (zh) 2020-08-07
CN110746507B (zh) 2020-06-26
CA3124726A1 (fr) 2020-07-02
CN111514292B (zh) 2023-06-20
US12297280B2 (en) 2025-05-13
CN111518211B (zh) 2022-06-21
AU2019416486B2 (en) 2022-07-07
EP3902837A1 (fr) 2021-11-03
EP3902837A4 (fr) 2022-06-15

Similar Documents

Publication Publication Date Title
EP3902837A4 (fr) Anticorps monoclonal contre le récepteur alpha de l'interleukine-4 humaine et son utilisation
EP3907240A4 (fr) Anticorps anti-tnfr2 et son utilisation
IL284216A (en) Anti-transferrin receptor antibodies and uses thereof
EP3802612A4 (fr) Anticorps anti-b7-h3 et son utilisation
EP3797124A4 (fr) Anticorps anti-ro1 et son utilisation
EP3887403A4 (fr) Anticorps anti-4-1bb et son utilisation
EP3523332A4 (fr) Anticorps anti-4-1 bb humain et son utilisation
EP3858856A4 (fr) Anticorps monoclonal anti-b7-h3 et son utilisation en thérapie cellulaire
IL285023A (en) Antibodies against il-7r alpha subunit and uses thereof
EP4289861A4 (fr) Anticorps contre la tslp humaine et leur utilisation
EP3999545A4 (fr) Anticorps anti-cd73 et son application
MA53015A (fr) Anticorps anti-sirp-bêta1 et procédés d'utilisation associés
EP3797123A4 (fr) Anticorps anti-ox40 et procédés d'utilisation
EP4397683A4 (fr) Anticorps monoclonal anti-interleukine-33 humaine et son utilisation
EP3819313A4 (fr) Anticorps bispécifique et son utilisation
EP4289862A4 (fr) Anticorps anti-b7-h3 humain et utilisation associée
EP3873941A4 (fr) Anticorps anti-pd-1 humain et procédés d'utilisation associés
EP3599249A4 (fr) Conjugué anticorps anti-5t4-médicament et son utilisation
EP3957652A4 (fr) Anticorps anti-fxi/fxia et son utilisation
EP3919515A4 (fr) Récepteur d'antigène chimère et utilisation correspondante
EP3710589A4 (fr) Anticorps anti-c1s et procédés d'utilisation
EP4032978A4 (fr) Récepteur antigénique chimérique ciblant cd19 et son utilisation
EP4083212A4 (fr) Protéine f rsv mutante et son utilisation
EP3873939A4 (fr) Anticorps anti-cd79b et récepteurs d'antigènes chimériques et leurs procédés d'utilisation
EP4083069A4 (fr) Anticorps anti-ox40 et utilisation associée