EP4393575A1 - Dispositif de mélange et procédé de mélange - Google Patents
Dispositif de mélange et procédé de mélange Download PDFInfo
- Publication number
- EP4393575A1 EP4393575A1 EP22307057.4A EP22307057A EP4393575A1 EP 4393575 A1 EP4393575 A1 EP 4393575A1 EP 22307057 A EP22307057 A EP 22307057A EP 4393575 A1 EP4393575 A1 EP 4393575A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cylinder
- supply
- orifice
- filling
- axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 98
- 238000000034 method Methods 0.000 title claims description 18
- 238000005086 pumping Methods 0.000 claims abstract description 77
- 239000000047 product Substances 0.000 claims abstract description 72
- 239000012530 fluid Substances 0.000 claims abstract description 39
- 238000004891 communication Methods 0.000 claims abstract description 35
- 239000012263 liquid product Substances 0.000 claims abstract description 23
- 239000000203 mixture Substances 0.000 claims description 38
- 230000000284 resting effect Effects 0.000 claims description 26
- 230000002441 reversible effect Effects 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 description 24
- 238000009472 formulation Methods 0.000 description 21
- 239000003814 drug Substances 0.000 description 18
- 229940079593 drug Drugs 0.000 description 16
- 230000007246 mechanism Effects 0.000 description 16
- 239000003085 diluting agent Substances 0.000 description 15
- 238000012546 transfer Methods 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 10
- 238000013519 translation Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 239000000470 constituent Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000013020 final formulation Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000011176 pooling Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
- B01F31/651—Mixing by successively aspirating a part of the mixture in a conduit, e.g. a piston, and reinjecting it through the same conduit into the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
- B01F35/882—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using measuring chambers, e.g. volumetric pumps, for feeding the substances
- B01F35/8822—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using measuring chambers, e.g. volumetric pumps, for feeding the substances using measuring chambers of the piston or plunger type
Definitions
- the present disclosure relates to a mixing device and a mixing method for mixing at least two products, at least one of said products being a liquid product.
- Such device can also be a way of having homecare treatment which enables to improve patient quality of life and treatment adherence.
- This disclosure aims at solving the aforementioned problems.
- the mixing device enables multiple combinations of transfer between a number of products contained in containers of different kinds which improves modularity.
- the cylinder orifice may open axially with respect to the cylinder axis and may be centered on the cylinder axis
- the attaching arrangement may comprise a connecting portion movable in rotation about the attaching axis with respect to the distribution portion, the connecting portion being provided with a connection duct arranged to be selectively put in fluid communication with one of the supply orifices, the connecting portion being configured to connect with the distal portion of the cylinder so as to put the cylinder orifice in fluid communication with the connection duct, and to move together with the cylinder in rotation about the attaching axis upon actuation of the cylinder actuator.
- a same syringe may be used as the pumping device for mixing the products and for administering the resulting mixture to the patient.
- the supply orifices may open axially with respect to the attaching axis and the cylinder orifice may open axially with respect to the cylinder axis, the cylinder orifice being offset with respect to the cylinder axis.
- the attaching arrangement may be configured to attach the cylinder in a removable manner.
- the attaching arrangement may comprise a housing extending along the attaching axis and configured to accommodate coaxially at least the distal portion of the cylinder.
- the first 55a and second 55b supply orifices and the filling orifice 45 are separate from each other and arranged in a same distribution plan perpendicular to the attaching axis A.
- the first 54a and second 54b supply conducts and the filling conduct 44 are formed by continuous protrusions 60 delimiting adjacent grooves on the outer surface of the lateral wall 31, the grooves being tightly closed by a sealing plate 61 fixed, especially welded, to the protrusions 60.
- the transmission mechanism 82 comprises two sliding members 90 each connected to the cylinder 11 so as to move the cylinder 11 in rotation about the attaching axis A between the aspiration opening and the exhaust opening of one of the supply ducts 54 as the sliding member 90 is moved in translation perpendicularly to the cylinder axis C.
- Each of the sliding members 90 is provided with a cylinder slot 91 extending parallel to the cylinder axis C.
- the transmission mechanism 82 could comprise only one of the sliding members 90.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22307057.4A EP4393575A1 (fr) | 2022-12-28 | 2022-12-28 | Dispositif de mélange et procédé de mélange |
| PCT/EP2023/087798 WO2024141528A1 (fr) | 2022-12-28 | 2023-12-26 | Dispositif de mélange et procédé de mélange |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22307057.4A EP4393575A1 (fr) | 2022-12-28 | 2022-12-28 | Dispositif de mélange et procédé de mélange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4393575A1 true EP4393575A1 (fr) | 2024-07-03 |
Family
ID=85017845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22307057.4A Withdrawn EP4393575A1 (fr) | 2022-12-28 | 2022-12-28 | Dispositif de mélange et procédé de mélange |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP4393575A1 (fr) |
| WO (1) | WO2024141528A1 (fr) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070088289A1 (en) * | 2005-08-19 | 2007-04-19 | Bargh Adrian N | Syringe pump |
| US20110208154A1 (en) * | 2007-03-15 | 2011-08-25 | Ulrich Haueter | Dosing device for an infusion system and method thereof |
| US20130261599A1 (en) * | 2010-11-25 | 2013-10-03 | Roche Diagnostics International Ag | Dosing Unit With Safety Valve |
| EP2654938A1 (fr) | 2010-12-24 | 2013-10-30 | Eveon | Dispositif pour mélanger au moins deux constituants |
| EP2822526A1 (fr) | 2012-03-09 | 2015-01-14 | Sensile Pat AG | Système de reconstitution de médicament |
| WO2015097323A1 (fr) * | 2013-12-26 | 2015-07-02 | Universidad De Málaga | Dispositif de perfusion de médicament fluide |
| EP3592405A1 (fr) | 2017-03-10 | 2020-01-15 | Enable Injections, Inc. | Dispositif, système et procédé de reconstitution |
| US10737057B1 (en) * | 2016-11-27 | 2020-08-11 | Albert A. Mikhail | Multiport syringe system for use with a urinary catheter |
-
2022
- 2022-12-28 EP EP22307057.4A patent/EP4393575A1/fr not_active Withdrawn
-
2023
- 2023-12-26 WO PCT/EP2023/087798 patent/WO2024141528A1/fr not_active Ceased
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070088289A1 (en) * | 2005-08-19 | 2007-04-19 | Bargh Adrian N | Syringe pump |
| US20110208154A1 (en) * | 2007-03-15 | 2011-08-25 | Ulrich Haueter | Dosing device for an infusion system and method thereof |
| US20130261599A1 (en) * | 2010-11-25 | 2013-10-03 | Roche Diagnostics International Ag | Dosing Unit With Safety Valve |
| EP2654938A1 (fr) | 2010-12-24 | 2013-10-30 | Eveon | Dispositif pour mélanger au moins deux constituants |
| EP2822526A1 (fr) | 2012-03-09 | 2015-01-14 | Sensile Pat AG | Système de reconstitution de médicament |
| WO2015097323A1 (fr) * | 2013-12-26 | 2015-07-02 | Universidad De Málaga | Dispositif de perfusion de médicament fluide |
| US10737057B1 (en) * | 2016-11-27 | 2020-08-11 | Albert A. Mikhail | Multiport syringe system for use with a urinary catheter |
| EP3592405A1 (fr) | 2017-03-10 | 2020-01-15 | Enable Injections, Inc. | Dispositif, système et procédé de reconstitution |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024141528A1 (fr) | 2024-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED |
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| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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| 18W | Application withdrawn |
Effective date: 20241220 |