EP4436603A4 - Behandlung einer demyelinisierenden erkrankung des zentralen nervensystems (zns) mit sativizumab - Google Patents

Behandlung einer demyelinisierenden erkrankung des zentralen nervensystems (zns) mit sativizumab

Info

Publication number
EP4436603A4
EP4436603A4 EP22898636.0A EP22898636A EP4436603A4 EP 4436603 A4 EP4436603 A4 EP 4436603A4 EP 22898636 A EP22898636 A EP 22898636A EP 4436603 A4 EP4436603 A4 EP 4436603A4
Authority
EP
European Patent Office
Prior art keywords
sativizumab
demyelinizing
cns
disease
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22898636.0A
Other languages
English (en)
French (fr)
Other versions
EP4436603A1 (de
Inventor
Takatoshi Ozawa
Mai Yamashiro
Hajime Ito
Shunsuke Yoshida
Jillian Smith
Ivana Vodopivec
Sian Lennon-Chrimes
Gaelle Klingelschmitt
Buedingen Hans-Christian Von
Baumann Hanna Silber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Chugai Pharmaceutical Co Ltd
Original Assignee
F Hoffmann La Roche AG
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2021/043459 external-priority patent/WO2023095305A1/en
Priority claimed from PCT/JP2021/048257 external-priority patent/WO2023119638A1/en
Application filed by F Hoffmann La Roche AG, Chugai Pharmaceutical Co Ltd filed Critical F Hoffmann La Roche AG
Publication of EP4436603A1 publication Critical patent/EP4436603A1/de
Publication of EP4436603A4 publication Critical patent/EP4436603A4/de
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP22898636.0A 2021-11-26 2022-11-25 Behandlung einer demyelinisierenden erkrankung des zentralen nervensystems (zns) mit sativizumab Pending EP4436603A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP2021/043459 WO2023095305A1 (en) 2021-11-26 2021-11-26 Treatment of a demyelinating disease of the central nervous system (cns) with satralizumab
PCT/JP2021/048257 WO2023119638A1 (en) 2021-12-24 2021-12-24 Treatment of a demyelinating disease of the central nervous system (cns) with satralizumab
PCT/JP2022/039605 WO2023095510A1 (en) 2021-11-26 2022-10-25 Treatment of a demyelinating disease of the central nervous system (cns) with satralizumab
PCT/JP2022/043453 WO2023095854A1 (en) 2021-11-26 2022-11-25 Treatment of a demyelinating disease of the central nervous system (cns) with satralizumab

Publications (2)

Publication Number Publication Date
EP4436603A1 EP4436603A1 (de) 2024-10-02
EP4436603A4 true EP4436603A4 (de) 2026-04-08

Family

ID=86539582

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22898636.0A Pending EP4436603A4 (de) 2021-11-26 2022-11-25 Behandlung einer demyelinisierenden erkrankung des zentralen nervensystems (zns) mit sativizumab

Country Status (2)

Country Link
EP (1) EP4436603A4 (de)
WO (1) WO2023095854A1 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
CA2972393A1 (en) * 2015-02-27 2016-09-01 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS CLINICALTRIALS ET AL: "Record History | ver. 12: 2022-11-21 | NCT05271409 | ClinicalTrials.gov", 21 November 2022 (2022-11-21), XP093324756, Retrieved from the Internet <URL:https://www.clinicaltrials.gov/study/NCT05271409?tab=history&a=12#version-content-panel> *
HEO YOUNG-A: "Satralizumab: First Approval", DRUGS, vol. 80, no. 14, 14 August 2020 (2020-08-14), Auckland, pages 1477 - 1482, XP93368542, ISSN: 0012-6667, Retrieved from the Internet <URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC7522096/pdf/40265_2020_Article_1380.pdf> DOI: 10.1007/s40265-020-01380-2 *
RINGELSTEIN MARIUS ET AL: "Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders", NEUROLOGY - NEUROIMMUNOLOGY NEUROINFLAMMATION, vol. 9, no. 1, 16 November 2021 (2021-11-16), pages e1100, XP093068098, DOI: 10.1212/NXI.0000000000001100 *
See also references of WO2023095854A1 *
YAMAMURA TAKASHI ET AL: "Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder", NEW ENGLAND JOURNAL OF MEDICINE, vol. 381, no. 22, 28 November 2019 (2019-11-28), United States, pages 2114 - 2124, XP093321210, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1901747 *

Also Published As

Publication number Publication date
WO2023095854A1 (en) 2023-06-01
EP4436603A1 (de) 2024-10-02

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