EP4453183A4 - Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture - Google Patents

Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture

Info

Publication number: EP4453183A4
Authority: EP; European Patent Office
Prior art keywords: cultural; optimizing; systems; methods; conditions
Prior art date: 2021-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP22912457.3A

Other languages

German (de)

English (en)

Other versions

EP4453183A2 (fr

Inventor

Shannon Hall

Ouwei Wang

Brian Lee

Charles Emrich

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pow Genetic Solutions Inc

Original Assignee

Pow Genetic Solutions Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2021-12-21

Filing date

2022-12-21

Publication date

2025-12-24

2022-12-21 Application filed by Pow Genetic Solutions Inc filed Critical Pow Genetic Solutions Inc

2024-10-30 Publication of EP4453183A2 publication Critical patent/EP4453183A2/fr

2025-12-24 Publication of EP4453183A4 publication Critical patent/EP4453183A4/fr

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/18—Flow directing inserts
- C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Sustainable Development (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Computer Hardware Design (AREA)
Thermal Sciences (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Computational Biology (AREA)
Evolutionary Biology (AREA)
Medical Informatics (AREA)
Spectroscopy & Molecular Physics (AREA)
Theoretical Computer Science (AREA)
Biophysics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP22912457.3A 2021-12-21 2022-12-21 Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture Pending EP4453183A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US202163292397P	2021-12-21	2021-12-21
PCT/US2022/053733 WO2023122224A2 (fr)	2021-12-21	2022-12-21	Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture

Publications (2)

Publication Number	Publication Date
EP4453183A2 EP4453183A2 (fr)	2024-10-30
EP4453183A4 true EP4453183A4 (fr)	2025-12-24

Family

ID=86903586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP22912457.3A Pending EP4453183A4 (fr)	2021-12-21	2022-12-21	Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture

Country Status (10)

Country	Link
US (1)	US20240209306A1 (fr)
EP (1)	EP4453183A4 (fr)
JP (1)	JP2025503486A (fr)
KR (1)	KR20240134140A (fr)
CN (1)	CN118805224A (fr)
AU (1)	AU2022418603A1 (fr)
CA (1)	CA3241931A1 (fr)
IL (1)	IL313759A (fr)
MX (1)	MX2024007773A (fr)
WO (1)	WO2023122224A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2025006354A2 (fr) *	2023-06-28	2025-01-02	Pow Genetic Solutions, Inc.	Procédés et systèmes pour optimiser des conditions de culture dans un processus de culture
CN117253555A (zh) *	2023-11-17	2023-12-19	山东阜丰发酵有限公司	一种改进黄原胶发酵工艺的方法及其运行系统
CN117745148B (zh) *	2024-02-10	2024-05-10	安徽省农业科学院烟草研究所	基于多源数据的稻茬烤烟种植质量评价方法及系统
CN119506387A (zh) *	2024-10-14	2025-02-25	苏州启和医疗科技有限公司	一种用于转染试剂高精度测试的转染效率检测方法
CN120015152B (zh) *	2025-04-21	2025-08-12	苏州工业园区旭太生物工程有限公司	一种多肽诱导型生物发酵培养基优化方法及系统
CN120183511A (zh) *	2025-05-22	2025-06-20	成都英德生物医药设备有限公司	生物反应器的动态优化方法以及系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20200202051A1 (en) *	2017-06-16	2020-06-25	Ge Healthcare Bio-Sciences Ab	Method for Predicting Outcome of an Modelling of a Process in a Bioreactor
US20200377844A1 (en) *	2017-12-29	2020-12-03	Hoffmann-La Roche Inc.	Predicting the metabolic condition of a cell culture
EP4116403A1 (fr) *	2021-07-07	2023-01-11	Sartorius Stedim Data Analytics AB	Surveillance, simulation et commande de bioprocessus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060199260A1 (en) *	2002-05-01	2006-09-07	Zhiyu Zhang	Microbioreactor for continuous cell culture
US20070037276A1 (en) *	2004-02-23	2007-02-15	Eudes Francois Marie De Crecy	Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants and producing a culture in a continuous manner
US10479969B2 (en) *	2010-10-11	2019-11-19	Phycoil Biotechnology International. Inc.	Utilization of wastewater for microalgal cultivation
EP3819368B1 (fr) *	2019-11-08	2022-03-30	Ceidos SA	Système de surveillance de culture cellulaire

2022
- 2022-12-21 JP JP2024537957A patent/JP2025503486A/ja active Pending
- 2022-12-21 IL IL313759A patent/IL313759A/en unknown
- 2022-12-21 EP EP22912457.3A patent/EP4453183A4/fr active Pending
- 2022-12-21 AU AU2022418603A patent/AU2022418603A1/en active Pending
- 2022-12-21 KR KR1020247024232A patent/KR20240134140A/ko active Pending
- 2022-12-21 CA CA3241931A patent/CA3241931A1/fr active Pending
- 2022-12-21 WO PCT/US2022/053733 patent/WO2023122224A2/fr not_active Ceased
- 2022-12-21 CN CN202280092308.6A patent/CN118805224A/zh active Pending
- 2022-12-21 US US18/287,287 patent/US20240209306A1/en active Pending
2024
- 2024-06-20 MX MX2024007773A patent/MX2024007773A/es unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20200202051A1 (en) *	2017-06-16	2020-06-25	Ge Healthcare Bio-Sciences Ab	Method for Predicting Outcome of an Modelling of a Process in a Bioreactor
US20200377844A1 (en) *	2017-12-29	2020-12-03	Hoffmann-La Roche Inc.	Predicting the metabolic condition of a cell culture
EP4116403A1 (fr) *	2021-07-07	2023-01-11	Sartorius Stedim Data Analytics AB	Surveillance, simulation et commande de bioprocessus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRELOAR NEYTHEN J. ET AL: "Deep reinforcement learning for the control of microbial co-cultures in bioreactors", PLOS COMPUTATIONAL BIOLOGY, vol. 16, no. 4, 10 April 2020 (2020-04-10), pages e1007783, XP093092307, DOI: 10.1371/journal.pcbi.1007783 *

Also Published As

Publication number	Publication date
JP2025503486A (ja)	2025-02-04
WO2023122224A3 (fr)	2023-09-14
KR20240134140A (ko)	2024-09-06
IL313759A (en)	2024-08-01
CA3241931A1 (fr)	2023-06-29
CN118805224A (zh)	2024-10-18
WO2023122224A2 (fr)	2023-06-29
EP4453183A2 (fr)	2024-10-30
US20240209306A1 (en)	2024-06-27
AU2022418603A1 (en)	2024-08-01
MX2024007773A (es)	2024-12-06

Legal Events

Date	Code	Title	Description
2023-07-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2024-09-27	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2024-09-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2024-10-30	17P	Request for examination filed	Effective date: 20240711
2024-10-30	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
2025-04-02	DAV	Request for validation of the european patent (deleted)
2025-04-02	DAX	Request for extension of the european patent (deleted)
2025-12-24	A4	Supplementary search report drawn up and despatched	Effective date: 20251124
2025-12-24	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 5/02 20060101AFI20251119BHEP Ipc: C12N 5/00 20060101ALI20251119BHEP Ipc: C12Q 1/02 20060101ALI20251119BHEP Ipc: G06N 3/12 20230101ALI20251119BHEP Ipc: G16B 5/00 20190101ALI20251119BHEP Ipc: G06N 3/00 20230101ALI20251119BHEP Ipc: C12M 1/36 20060101ALI20251119BHEP

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