EP4719458A2 - Invertierte il10-monomere - Google Patents

Invertierte il10-monomere

Info

Publication number
EP4719458A2
EP4719458A2 EP24816634.0A EP24816634A EP4719458A2 EP 4719458 A2 EP4719458 A2 EP 4719458A2 EP 24816634 A EP24816634 A EP 24816634A EP 4719458 A2 EP4719458 A2 EP 4719458A2
Authority
EP
European Patent Office
Prior art keywords
seq
amino acid
polypeptide
human
monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24816634.0A
Other languages
English (en)
French (fr)
Inventor
Andrew Morin
Tatjana PETOJEVIC
Mahalakshmi RAMADASS
Bhargavi JAYARAMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthekine Inc
Original Assignee
Synthekine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthekine Inc filed Critical Synthekine Inc
Publication of EP4719458A2 publication Critical patent/EP4719458A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
EP24816634.0A 2023-06-01 2024-05-31 Invertierte il10-monomere Pending EP4719458A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363505651P 2023-06-01 2023-06-01
PCT/US2024/032147 WO2024249957A2 (en) 2023-06-01 2024-05-31 Il10 inverted monomers

Publications (1)

Publication Number Publication Date
EP4719458A2 true EP4719458A2 (de) 2026-04-08

Family

ID=93658692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24816634.0A Pending EP4719458A2 (de) 2023-06-01 2024-05-31 Invertierte il10-monomere

Country Status (7)

Country Link
EP (1) EP4719458A2 (de)
KR (1) KR20260034079A (de)
CN (1) CN121666243A (de)
AU (1) AU2024280480C1 (de)
IL (1) IL324787A (de)
MX (1) MX2025014325A (de)
WO (1) WO2024249957A2 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3927728A2 (de) * 2019-02-21 2021-12-29 Xencor, Inc. Ungezielte und zielgerichtete il-10-fc-fusionsproteine
EP3795583A1 (de) * 2019-09-19 2021-03-24 Ecole Polytechnique Federale de Lausanne (EPFL) Il10/fc-fusionsproteine als verstärker von immuntherapien
JP2023514152A (ja) * 2020-02-06 2023-04-05 ブリストル－マイヤーズ スクイブ カンパニー Ｉｌ－１０およびその使用
WO2021231447A1 (en) * 2020-05-12 2021-11-18 Regeneron Pharmaceuticals, Inc. Novel il10 agonists and methods of use thereof
JP2023548311A (ja) * 2020-10-29 2023-11-16 ブリストル－マイヤーズ スクイブ カンパニー 疾患の治療のための融合タンパク質

Also Published As

Publication number Publication date
AU2024280480A1 (en) 2025-12-04
MX2025014325A (es) 2026-03-02
WO2024249957A3 (en) 2025-03-13
CN121666243A (zh) 2026-03-13
IL324787A (en) 2026-01-01
AU2024280480C1 (en) 2026-01-29
WO2024249957A2 (en) 2024-12-05
KR20260034079A (ko) 2026-03-10

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