EP4721819A2 - Stabilen bakteriellen extrakten als arzneimittel - Google Patents

Stabilen bakteriellen extrakten als arzneimittel

Info

Publication number: EP4721819A2
Authority: EP; European Patent Office
Prior art keywords: acid; bacterial; bacterial extract; lactobacillus; extract
Prior art date: 2019-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP26159123.4A

Other languages

English (en)

French (fr)

Inventor

Jacques Bauer

Christian PASQUALI

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

OM Pharma SA

Original Assignee

OM Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-03-14

Filing date

2020-03-12

Publication date

2026-04-08

2020-03-12 Application filed by OM Pharma SA filed Critical OM Pharma SA

2026-04-08 Publication of EP4721819A2 publication Critical patent/EP4721819A2/de

Status Pending legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/08—Reducing the nucleic acid content
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Inorganic Chemistry (AREA)
Dispersion Chemistry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

EP26159123.4A 2019-03-14 2020-03-12 Stabilen bakteriellen extrakten als arzneimittel Pending EP4721819A2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP19162912		2019-03-14
PCT/EP2020/056742 WO2020182970A1 (en)	2019-03-14	2020-03-12	Process for making stable bacterial extracts and their use as pharmaceuticals
EP20712877.8A EP3937957B1 (de)	2019-03-14	2020-03-12	Prozess zur herstellung von stabilen bakterienextrakten und deren verwendung als arzneimitteln

Related Parent Applications (2)

Application Number	Title	Priority Date	Filing Date
EP20712877.8A Division EP3937957B1 (de)	2019-03-14	2020-03-12	Prozess zur herstellung von stabilen bakterienextrakten und deren verwendung als arzneimitteln
EP20712877.8A Division-Into EP3937957B1 (de)	2019-03-14	2020-03-12	Prozess zur herstellung von stabilen bakterienextrakten und deren verwendung als arzneimitteln

Publications (1)

Publication Number	Publication Date
EP4721819A2 true EP4721819A2 (de)	2026-04-08

Family

ID=65991511

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
EP23181587.9A Pending EP4234026A3 (de)	2019-03-14	2020-03-12	Verfahren zur herstellung von stabilen bakteriellen extrakten und ihre verwendung als arzneimittel
EP20712877.8A Active EP3937957B1 (de)	2019-03-14	2020-03-12	Prozess zur herstellung von stabilen bakterienextrakten und deren verwendung als arzneimitteln
EP26159123.4A Pending EP4721819A2 (de)	2019-03-14	2020-03-12	Stabilen bakteriellen extrakten als arzneimittel

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
EP23181587.9A Pending EP4234026A3 (de)	2019-03-14	2020-03-12	Verfahren zur herstellung von stabilen bakteriellen extrakten und ihre verwendung als arzneimittel
EP20712877.8A Active EP3937957B1 (de)	2019-03-14	2020-03-12	Prozess zur herstellung von stabilen bakterienextrakten und deren verwendung als arzneimitteln

Country Status (19)

Country	Link
US (3)	US11801271B2 (de)
EP (3)	EP4234026A3 (de)
JP (2)	JP2022525177A (de)
KR (1)	KR102922470B1 (de)
CN (1)	CN113840615A (de)
BR (1)	BR112021018006A2 (de)
CA (1)	CA3132564A1 (de)
CL (1)	CL2021002401A1 (de)
CO (1)	CO2021013677A2 (de)
CR (1)	CR20210515A (de)
CU (1)	CU20210077A7 (de)
IL (1)	IL286215B2 (de)
MA (1)	MA55291A (de)
MX (1)	MX2021010912A (de)
PE (1)	PE20212261A1 (de)
PH (1)	PH12021552089A1 (de)
SG (1)	SG11202109937UA (de)
WO (1)	WO2020182970A1 (de)
ZA (1)	ZA202106914B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR112021018086A2 (pt) *	2019-03-14	2021-11-23	Univ Arizona	Método de tratamento e/ou prevenção de asma, exacerbações de asma, asma alérgica e/ou condições associadas com microbiota relacionadas a distúrbios respiratórios
TW202304485A (zh) *	2021-04-12	2023-02-01	香港中文大學	用於增強免疫力的方法和組合物
KR20220152156A (ko) *	2021-05-07	2022-11-15	시므라이즈 아게	락토바실러스 종의 신규한 박테리아 발효물
WO2022233441A1 (en) *	2021-05-07	2022-11-10	Symrise Ag	Novel bacterial ferment of lactobacillus species
EP4134426A1 (de) *	2021-08-13	2023-02-15	Symrise AG	Neues bakterielles ferment von lactobacillus-spezies
CN118475359A (zh) *	2021-12-22	2024-08-09	株式会社明治	用于预防继发感染症或用于降低继发感染症发生风险的组合物
KR102763094B1 (ko) *	2022-12-09	2025-02-12	대한민국	혈관 염증 완화에 효과적인 식용 곰팡이 균주의 가수분해 물질의 제조 방법
CN118460405B (zh) *	2024-04-26	2025-03-04	广东悦创生物科技有限公司	一株副干酪乳酪杆菌xy6及其在制备调理肠胃和减肥药品中的应用
CN121427776B (zh) *	2025-12-26	2026-04-10	威凯海思(山东)生物工程有限公司	一株罗伊氏粘液乳杆菌hc1602及其菌剂和应用

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US4353365A (en)	1979-12-06	1982-10-12	Glaxo Group Limited	Device for dispensing medicaments
US4524769A (en)	1981-07-08	1985-06-25	Aktiebolaget Draco	Dosage inhalator
US5035237A (en)	1985-07-30	1991-07-30	Newell Robert E	Devices for administering medicaments to patients
US5424287A (en)	1992-02-14	1995-06-13	Laboratoires Om Sa	Extract of bacterial macromolecules, a process for its preparation and a pharmaceutical composition containing the same
WO1997012687A1 (en)	1995-10-04	1997-04-10	Boehringer Ingelheim International Gmbh	Device of miniaturised construction for producing high pressure in a fluid to be atomised
US6123068A (en)	1993-05-21	2000-09-26	Aradigm Corporation	Systems for the intrapulmonary delivery of aerosolized aqueous formulations
US6378519B1 (en)	1990-03-02	2002-04-30	Glaxo Group Limited	Inhalation device
WO2008109667A2 (en)	2007-03-05	2008-09-12	Om Pharma	Bacterial extract for digestive or urinary tract disorders and process for its preparation
WO2008109669A2 (en)	2007-03-05	2008-09-12	Om Pharma	Bacterial extract for respiratory disorders and proces for its preparation
US7434579B2 (en)	2000-02-01	2008-10-14	Valois S.A.S	Breath actuated dry powder inhaler and tape dose strip
US7568480B2 (en)	2001-12-21	2009-08-04	Trudell Medical International	Nebulizer apparatus and method
WO2010027344A1 (en)	2008-09-04	2010-03-11	Om Pharma	Immunomodulatory extracts from lactobacillus bacteria and methods of manufacturing and use thereof

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DK1817423T3 (en) *	2004-11-30	2015-01-26	Merial Ltd	Mixing units for chemical light ring of cells
WO2008085549A2 (en) *	2006-07-28	2008-07-17	Board Of Regents Of The University Of Texas System	Compositions and methods for stimulation of lung innate immunity
FR2923491B1 (fr) *	2007-11-14	2012-12-14	Deinove Sa	Utilisation de bacteries pour la production de sources de bioenergie
GB0818453D0 (en) *	2008-10-08	2008-11-12	Novartis Ag	Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
ES2356883B1 (es)	2008-07-24	2012-02-22	Bcn Peptides, S.A.	Composición para el tratamiento del dolor y/o la inflamación.
RU2425691C1 (ru)	2010-07-15	2011-08-10	ВАКЕ спол с.р.о.	Аэрозольный препарат на основе апротинина для лечения вирусных респираторных инфекций
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2020
- 2020-03-12 CA CA3132564A patent/CA3132564A1/en active Pending
- 2020-03-12 JP JP2021555329A patent/JP2022525177A/ja active Pending
- 2020-03-12 SG SG11202109937U patent/SG11202109937UA/en unknown
- 2020-03-12 MA MA055291A patent/MA55291A/fr unknown
- 2020-03-12 IL IL286215A patent/IL286215B2/en unknown
- 2020-03-12 CN CN202080035416.0A patent/CN113840615A/zh active Pending
- 2020-03-12 BR BR112021018006A patent/BR112021018006A2/pt unknown
- 2020-03-12 WO PCT/EP2020/056742 patent/WO2020182970A1/en not_active Ceased
- 2020-03-12 PE PE2021001517A patent/PE20212261A1/es unknown
- 2020-03-12 EP EP23181587.9A patent/EP4234026A3/de active Pending
- 2020-03-12 CR CR20210515A patent/CR20210515A/es unknown
- 2020-03-12 EP EP20712877.8A patent/EP3937957B1/de active Active
- 2020-03-12 EP EP26159123.4A patent/EP4721819A2/de active Pending
- 2020-03-12 MX MX2021010912A patent/MX2021010912A/es unknown
- 2020-03-12 PH PH1/2021/552089A patent/PH12021552089A1/en unknown
- 2020-03-12 CU CU2021000077A patent/CU20210077A7/es unknown
- 2020-03-12 KR KR1020217032875A patent/KR102922470B1/ko active Active
2021
- 2021-09-14 CL CL2021002401A patent/CL2021002401A1/es unknown
- 2021-09-14 US US17/474,242 patent/US11801271B2/en active Active
- 2021-09-17 ZA ZA2021/06914A patent/ZA202106914B/en unknown
- 2021-10-13 CO CONC2021/0013677A patent/CO2021013677A2/es unknown
2023
- 2023-06-30 US US18/345,619 patent/US20230346855A1/en not_active Abandoned
2024
- 2024-12-06 US US18/971,615 patent/US20250195587A1/en active Pending
2025
- 2025-08-29 JP JP2025144166A patent/JP2025176089A/ja active Pending

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Publication number	Priority date	Publication date	Assignee	Title
US4353365A (en)	1979-12-06	1982-10-12	Glaxo Group Limited	Device for dispensing medicaments
US4524769A (en)	1981-07-08	1985-06-25	Aktiebolaget Draco	Dosage inhalator
US5035237A (en)	1985-07-30	1991-07-30	Newell Robert E	Devices for administering medicaments to patients
US6378519B1 (en)	1990-03-02	2002-04-30	Glaxo Group Limited	Inhalation device
US5424287A (en)	1992-02-14	1995-06-13	Laboratoires Om Sa	Extract of bacterial macromolecules, a process for its preparation and a pharmaceutical composition containing the same
US6123068A (en)	1993-05-21	2000-09-26	Aradigm Corporation	Systems for the intrapulmonary delivery of aerosolized aqueous formulations
WO1997012687A1 (en)	1995-10-04	1997-04-10	Boehringer Ingelheim International Gmbh	Device of miniaturised construction for producing high pressure in a fluid to be atomised
US7434579B2 (en)	2000-02-01	2008-10-14	Valois S.A.S	Breath actuated dry powder inhaler and tape dose strip
US7568480B2 (en)	2001-12-21	2009-08-04	Trudell Medical International	Nebulizer apparatus and method
WO2008109667A2 (en)	2007-03-05	2008-09-12	Om Pharma	Bacterial extract for digestive or urinary tract disorders and process for its preparation
WO2008109669A2 (en)	2007-03-05	2008-09-12	Om Pharma	Bacterial extract for respiratory disorders and proces for its preparation
US9463209B2 (en)	2007-03-05	2016-10-11	Om Pharma Sa	Bacterial extract for respiratory disorders and process for its preparation
WO2010027344A1 (en)	2008-09-04	2010-03-11	Om Pharma	Immunomodulatory extracts from lactobacillus bacteria and methods of manufacturing and use thereof

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"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING COMPANY
BRIICKNER, HT. WESTHAUSERH. GODEL: "Liquid chromatographic determination of D- and L-amino acids by derivatization with 0-phthaldialdehyde and N-isobutyryl-L-cysteine", J. CHROMATOGRAPHY A, vol. 711, 1995, pages 201 - 21
CLARENCE M. ET AL.: "Abstract", 30 March 2018, ST-JOHN UNIVERSITY
D. HERBERT ET AL., METH. MICROBIOL, vol. 5B, 1971, pages 266 - 135
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PASQUALI ET AL., FRONTIERS IN MEDICINE, vol. 1, 2014, pages 41
ROTH M ET AL., PLOS ONE, vol. 12, 2017, pages 0188010
ROTH M ET AL., PLOS ONE, vol. 12, no. 11, 2017, pages 0188010
ROTH M: "Fluorescence reaction for amino acids", ANAL. CHEM., vol. 43, 1971, pages 880 - 882
YOUNG VB ET AL., BMJ, vol. 356, 2017, pages j831

Also Published As

Publication number	Publication date
IL286215B1 (en)	2025-04-01
CO2021013677A2 (es)	2021-10-20
IL286215B2 (en)	2025-08-01
WO2020182970A1 (en)	2020-09-17
ZA202106914B (en)	2023-10-25
JP2025176089A (ja)	2025-12-03
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