EP4724443A1 - Pyrazolo-pyrimidinon-verbindungen zur verwendung in verfahren zur hemmung von wee1-a-kinase - Google Patents

Pyrazolo-pyrimidinon-verbindungen zur verwendung in verfahren zur hemmung von wee1-a-kinase

Info

Publication number
EP4724443A1
EP4724443A1 EP24739831.6A EP24739831A EP4724443A1 EP 4724443 A1 EP4724443 A1 EP 4724443A1 EP 24739831 A EP24739831 A EP 24739831A EP 4724443 A1 EP4724443 A1 EP 4724443A1
Authority
EP
European Patent Office
Prior art keywords
compound
methyl
dihydro
cancer
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24739831.6A
Other languages
English (en)
French (fr)
Inventor
Hans Mattias JÖNSSON
Nima RAJABI
Filip Alexander PAULSEN
Andrea ÖHLANDER
Björn BORGSTRÖM
Magnus Munck AF ROSENSCHÖLD
Lars Thomas BRIMERT
Caroline Maria WIGERUP
John Henry Van Duzer
David Proia
Lei Shi
Åsa Helén NILSSON
Mette LAURSEN
Bo Roger SVENSSON
Joon O. Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acrivon Therapeutics Inc
Original Assignee
Acrivon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acrivon Therapeutics Inc filed Critical Acrivon Therapeutics Inc
Publication of EP4724443A1 publication Critical patent/EP4724443A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
EP24739831.6A 2023-06-09 2024-06-07 Pyrazolo-pyrimidinon-verbindungen zur verwendung in verfahren zur hemmung von wee1-a-kinase Pending EP4724443A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202363472105P 2023-06-09 2023-06-09
US202363608086P 2023-12-08 2023-12-08
US202463635197P 2024-04-17 2024-04-17
PCT/US2024/033065 WO2024254490A1 (en) 2023-06-09 2024-06-07 Pyrazolo-pyrimidinone compounds for use in methods of inhibiting wee1 a kinase

Publications (1)

Publication Number Publication Date
EP4724443A1 true EP4724443A1 (de) 2026-04-15

Family

ID=91853604

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24739831.6A Pending EP4724443A1 (de) 2023-06-09 2024-06-07 Pyrazolo-pyrimidinon-verbindungen zur verwendung in verfahren zur hemmung von wee1-a-kinase

Country Status (9)

Country Link
EP (1) EP4724443A1 (de)
KR (1) KR20260039689A (de)
CN (1) CN121752567A (de)
AU (1) AU2024284667A1 (de)
CO (1) CO2026000188A2 (de)
IL (1) IL325136A (de)
MX (1) MX2025014761A (de)
TW (1) TW202504610A (de)
WO (1) WO2024254490A1 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2902050T3 (es) * 2017-01-23 2022-03-24 Shijiazhuang Sagacity New Drug Dev Co Ltd Derivado 1,2-dihidro-3H-pirazolo[3,4-D]pirimidin-3-ona como inhibidor de Wee1
WO2019074979A1 (en) * 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF

Also Published As

Publication number Publication date
CN121752567A (zh) 2026-03-27
IL325136A (en) 2026-02-01
WO2024254490A1 (en) 2024-12-12
KR20260039689A (ko) 2026-03-20
CO2026000188A2 (es) 2026-04-06
MX2025014761A (es) 2026-01-07
AU2024284667A1 (en) 2026-01-15
TW202504610A (zh) 2025-02-01

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