EP4731207A2 - Inhibiteurs du virus respiratoire syncytial humain et du métapneumovirus - Google Patents

Inhibiteurs du virus respiratoire syncytial humain et du métapneumovirus

Info

Publication number
EP4731207A2
EP4731207A2 EP24832714.0A EP24832714A EP4731207A2 EP 4731207 A2 EP4731207 A2 EP 4731207A2 EP 24832714 A EP24832714 A EP 24832714A EP 4731207 A2 EP4731207 A2 EP 4731207A2
Authority
EP
European Patent Office
Prior art keywords
mmol
mixture
pyridin
methyl
concentrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24832714.0A
Other languages
German (de)
English (en)
Inventor
Douglas C. Beshore
Brett R. AMBLER
Kira A. Armacost
Christopher James BUNGARD
Danielle M. Hurzy
Peter J. Manley
Kelly-Ann S. Schlegel
Linda M. Suen-Lai
Mahdieh YAZDANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of EP4731207A2 publication Critical patent/EP4731207A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente divulgation concerne des composés de formule I : (I) et leur utilisation en tant qu'agents antiviraux pour l'inhibition de la réplication du VRSh et du MPVh et le traitement et la prophylaxie de l'infection par VRSh et MPVh.
EP24832714.0A 2023-06-26 2024-06-20 Inhibiteurs du virus respiratoire syncytial humain et du métapneumovirus Pending EP4731207A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363510235P 2023-06-26 2023-06-26
PCT/US2024/034649 WO2025006293A2 (fr) 2023-06-26 2024-06-20 Inhibiteurs du virus respiratoire syncytial humain et du métapneumovirus

Publications (1)

Publication Number Publication Date
EP4731207A2 true EP4731207A2 (fr) 2026-04-29

Family

ID=93940129

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24832714.0A Pending EP4731207A2 (fr) 2023-06-26 2024-06-20 Inhibiteurs du virus respiratoire syncytial humain et du métapneumovirus

Country Status (2)

Country Link
EP (1) EP4731207A2 (fr)
WO (1) WO2025006293A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354403B2 (en) * 2009-08-27 2013-01-15 Merck Sharp & Dohme Corp. Pyrrolidine derived beta 3 adrenergic receptor agonists
ES2969565T3 (es) * 2015-09-30 2024-12-13 Max Planck Ges Zur Foerderung Derwissenschaften E V Derivados heteroarílicos como inhibidores de la sepiapterina reductasa
WO2023061617A1 (fr) * 2020-12-21 2023-04-20 F. Hoffmann-La Roche Ag Composés de sulfonylpipérazinyle pour le traitement d'infections bactériennes

Also Published As

Publication number Publication date
WO2025006293A2 (fr) 2025-01-02
WO2025006293A3 (fr) 2025-02-13

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