ES2000476A6 - Un procedimiento para preparar derivados diazinilpiperidinilicos con propiedades psicogeriatricas - Google Patents
Un procedimiento para preparar derivados diazinilpiperidinilicos con propiedades psicogeriatricasInfo
- Publication number
- ES2000476A6 ES2000476A6 ES8600190A ES8600190A ES2000476A6 ES 2000476 A6 ES2000476 A6 ES 2000476A6 ES 8600190 A ES8600190 A ES 8600190A ES 8600190 A ES8600190 A ES 8600190A ES 2000476 A6 ES2000476 A6 ES 2000476A6
- Authority
- ES
- Spain
- Prior art keywords
- ring
- alkyl
- diazinylpiperidine
- derivatives
- pyridazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000006883 memory enhancing effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DIAZINILPIPERIDINILICOS CON PROPIEDADES PSICOGERIATRICAS, DE FORMULA I, SEGUN SE DESCRIBE EN LA DESCRIPCION, QUE COMPRENDE LA COPULACION DE UN ESTER PIPERIDINCARBOXILICO CON UN HALURO DE DIAZINA APROPIADO, SEGUIDO DE TRATAMIENTO CON UN REACTIVO ORGANOMETALICO, POSTERIOR SUSTITUCION DEL GRUPO HIDROXI POR OTRO GRUPO SALIENTE Y COPULACION CON UNA AMIDA O IMIDA CICLICA. LOS ENSAYOS FARMACOLOGICOS DEMUESTRAN QUE LOS COMPUESTOS DE FORMULA I SON CAPACES DE INVERTIR LA AMNESIA INDUCIDA POR SEC EN UN ENSAYO DE RESPUESTA DE EVITACION PASIVA DEL DESCENSO. ASIMISMO ESTOS COMPUESTOS EJERCEN ACTIVIDAD INCREMENTADORA DE LA COGNICION Y DE LA MEMORIA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75300685A | 1985-07-08 | 1985-07-08 | |
| US86846886A | 1986-05-30 | 1986-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2000476A6 true ES2000476A6 (es) | 1988-03-01 |
Family
ID=27115677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8600190A Expired ES2000476A6 (es) | 1985-07-08 | 1986-07-08 | Un procedimiento para preparar derivados diazinilpiperidinilicos con propiedades psicogeriatricas |
Country Status (28)
| Country | Link |
|---|---|
| KR (1) | KR940003756B1 (es) |
| CN (1) | CN1012364B (es) |
| AT (1) | AT395850B (es) |
| AU (1) | AU595215B2 (es) |
| BE (1) | BE905061A (es) |
| CA (1) | CA1272725A (es) |
| CH (1) | CH671579A5 (es) |
| CY (1) | CY1630A (es) |
| DE (1) | DE3622842C2 (es) |
| DK (1) | DK170441B1 (es) |
| EG (1) | EG18310A (es) |
| ES (1) | ES2000476A6 (es) |
| FI (1) | FI88300C (es) |
| FR (1) | FR2584408B1 (es) |
| GB (1) | GB2177692B (es) |
| GR (1) | GR861765B (es) |
| HK (1) | HK11292A (es) |
| HU (1) | HU199455B (es) |
| IE (1) | IE59424B1 (es) |
| IL (1) | IL79351A (es) |
| IT (1) | IT1196467B (es) |
| NL (1) | NL8601763A (es) |
| NO (1) | NO167389C (es) |
| NZ (1) | NZ216720A (es) |
| PT (1) | PT82942B (es) |
| SE (1) | SE462491B (es) |
| SG (1) | SG111091G (es) |
| YU (2) | YU45017B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
| FR2634208B1 (fr) * | 1988-07-12 | 1990-11-23 | Synthelabo | Derives de ((piperidinyl-4)methyl)-2 dihydro-2,3 1h-isoindole, leur preparation et leur application en therapeutique |
| US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
| HU206878B (en) * | 1989-10-27 | 1993-01-28 | Bristol Myers Squibb Co | Process for producing 1-//1-/2-/trifluoromethyl/-4-pyrimidinyl/-4-piperidinyl/-methyl/-2-pirrolidinone |
| CA2069318A1 (en) * | 1989-10-27 | 1991-04-28 | Engelbert Ciganek | (n-phthalimidoalkyl) piperidines |
| US5098904A (en) * | 1990-06-27 | 1992-03-24 | Bristol-Myers Squibb Company | Cerebral function enhancing pyrimidinyl derivatives |
| US5240934A (en) * | 1990-10-19 | 1993-08-31 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
| US5190951A (en) * | 1990-10-19 | 1993-03-02 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
| US5401744A (en) * | 1993-10-04 | 1995-03-28 | Bristol-Myers Squibb Company | Useful hemi-hydrate form of a cerebral function enhancing agent |
| CN106188039B (zh) * | 2016-06-30 | 2019-01-01 | 广东工业大学 | 一种二酮衍生物及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| ZA76475B (en) * | 1975-03-10 | 1977-08-31 | Ciba Geigy Ag | Indolyalkylpiperidines |
| EP0009465A1 (de) * | 1978-09-20 | 1980-04-02 | Ciba-Geigy Ag | N-(1-(4-Amino-2-chinazolinyl)-3- oder -4-piperidyl-lactame, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate enthaltend diese Verbindungen |
| US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
-
1986
- 1986-07-01 NZ NZ216720A patent/NZ216720A/xx unknown
- 1986-07-03 FI FI862830A patent/FI88300C/fi not_active IP Right Cessation
- 1986-07-03 YU YU1186/86A patent/YU45017B/xx unknown
- 1986-07-03 FR FR8609666A patent/FR2584408B1/fr not_active Expired
- 1986-07-07 DK DK323986A patent/DK170441B1/da not_active IP Right Cessation
- 1986-07-07 IL IL79351A patent/IL79351A/xx not_active IP Right Cessation
- 1986-07-07 CA CA000513196A patent/CA1272725A/en not_active Expired - Lifetime
- 1986-07-07 NL NL8601763A patent/NL8601763A/nl active Search and Examination
- 1986-07-07 BE BE0/216887A patent/BE905061A/fr not_active IP Right Cessation
- 1986-07-07 CH CH2740/86A patent/CH671579A5/de not_active IP Right Cessation
- 1986-07-07 GB GB8616504A patent/GB2177692B/en not_active Expired
- 1986-07-07 NO NO862729A patent/NO167389C/no not_active IP Right Cessation
- 1986-07-07 HU HU862835A patent/HU199455B/hu unknown
- 1986-07-07 IE IE182686A patent/IE59424B1/en not_active IP Right Cessation
- 1986-07-07 AU AU59787/86A patent/AU595215B2/en not_active Expired
- 1986-07-07 IT IT21049/86A patent/IT1196467B/it active
- 1986-07-07 GR GR861765A patent/GR861765B/el unknown
- 1986-07-07 SE SE8603026A patent/SE462491B/sv not_active IP Right Cessation
- 1986-07-08 CN CN86104681A patent/CN1012364B/zh not_active Expired
- 1986-07-08 PT PT82942A patent/PT82942B/pt unknown
- 1986-07-08 DE DE3622842A patent/DE3622842C2/de not_active Expired - Lifetime
- 1986-07-08 EG EG416/86A patent/EG18310A/xx active
- 1986-07-08 AT AT0185286A patent/AT395850B/de not_active IP Right Cessation
- 1986-07-08 ES ES8600190A patent/ES2000476A6/es not_active Expired
- 1986-07-08 KR KR1019860005480A patent/KR940003756B1/ko not_active Expired - Fee Related
-
1987
- 1987-06-10 YU YU1073/87A patent/YU44947B/xx unknown
-
1991
- 1991-12-31 SG SG1110/91A patent/SG111091G/en unknown
-
1992
- 1992-02-13 HK HK112/92A patent/HK11292A/xx not_active IP Right Cessation
- 1992-07-10 CY CY1630A patent/CY1630A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20060710 |