ES2001641A6 - Procedimiento para la obtencion de nuevas dihidropiridin-2-hidroxiaminas. - Google Patents

Procedimiento para la obtencion de nuevas dihidropiridin-2-hidroxiaminas.

Info

Publication number
ES2001641A6
ES2001641A6 ES8601577A ES8601577A ES2001641A6 ES 2001641 A6 ES2001641 A6 ES 2001641A6 ES 8601577 A ES8601577 A ES 8601577A ES 8601577 A ES8601577 A ES 8601577A ES 2001641 A6 ES2001641 A6 ES 2001641A6
Authority
ES
Spain
Prior art keywords
chain
straight
aryl
optionally
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601577A
Other languages
English (en)
Inventor
Eckhard Schwenner
Gunther Kinast
Andreas Knorr
Stanislav Kazda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES2001641A6 publication Critical patent/ES2001641A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVAS DIHIDROPIRIDIN-2-HIDROXIAMINAS DE FORMULA I DONDE R ES UN RADICAL ALQUILO O HETEROCICLICO; R1 ES UN RESTO HIDROCARBONADO DE CADENA LINEAL, RAMIFICADA O CICLICA OPCIONALMENTE CONTENIENDO UN HETEROATOMO; R2 ES H, CIANO, ARILO, ALQUILO O ARALQUILO; R3 ES H, ALQUILO CON HASTA 2 ATOMOS DE O, ARILO O ARALQUILO; R4 ES H, ALQUILO, ARILO, ARALQUILO, UN RESTO CARBONILO, SULFONA O HIDROXI-ETER; R5 ES ARILO O HETEROARILO SUSTITUIDO; A ES UN GRUPO ALQUILENO Y X ES UN RESTO CARBONILO, PUDIENDO ESTAR OPCIONALMENTE SUSTITUIDAS TODAS LAS RADICALES. EL PROCEDIMIENTO COMPRENDE LA REACCION ENTRE UNA DIHIDROPIRIDINA (II) Y UN EPOXIDO (III) SE DESCRIBE TAMBIEN UN PROCEDIMIENTO PARA OBTENER EL COMPUESTO II. LOS PRODUCTOS ASI OBTENIDOS SON UTILES PARA SU EMPLEO EN MEDICAMENTOS INFLUENCIADORES DEL SISTEMA CIRCULATORIO.
ES8601577A 1985-09-04 1986-09-03 Procedimiento para la obtencion de nuevas dihidropiridin-2-hidroxiaminas. Expired ES2001641A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853531498 DE3531498A1 (de) 1985-09-04 1985-09-04 Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
ES2001641A6 true ES2001641A6 (es) 1988-06-01

Family

ID=6280061

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601577A Expired ES2001641A6 (es) 1985-09-04 1986-09-03 Procedimiento para la obtencion de nuevas dihidropiridin-2-hidroxiaminas.

Country Status (11)

Country Link
EP (1) EP0218068A1 (es)
JP (1) JPS6256474A (es)
KR (1) KR870003071A (es)
AU (1) AU6216086A (es)
DE (1) DE3531498A1 (es)
DK (1) DK420986A (es)
ES (1) ES2001641A6 (es)
FI (1) FI863537A7 (es)
GR (1) GR862249B (es)
PT (1) PT83293B (es)
ZA (1) ZA866683B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254682A1 (de) * 1986-07-22 1988-01-27 Ciba-Geigy Ag Neue Phenoxyaliphatylphenylenoxyalkylester und -amide
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
GB8712747D0 (en) * 1987-05-30 1987-07-01 Pfizer Ltd Therapeutic agents
US5468746A (en) * 1988-07-29 1995-11-21 Zambon Group S.P.A. Compounds active on the cardiovascular system
EP0352863A3 (en) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. 1,4-dihydropyridine dicarboxylic acid derivatives
GB9102031D0 (en) * 1991-01-30 1991-03-13 Fujisawa Pharmaceutical Co Dihydropyridine compounds,and process for their preparation
GB9117340D0 (en) * 1991-08-10 1991-09-25 Fujisawa Pharmaceutical Co Dihydropyridine compounds,and process for their preparation
FR2700541B1 (fr) * 1993-01-21 1995-03-03 Adir Nouveaux composés de 1,4-dihydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1455502A (en) * 1973-02-20 1976-11-10 Yamanouchi Pharma Co Ltd 1,4-dihydropyridine derivatives
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法

Also Published As

Publication number Publication date
JPS6256474A (ja) 1987-03-12
DE3531498A1 (de) 1987-03-05
DK420986D0 (da) 1986-09-03
ZA866683B (en) 1987-05-27
PT83293B (en) 1988-10-06
FI863537A7 (fi) 1987-03-05
FI863537A0 (fi) 1986-09-02
PT83293A (pt) 1986-10-01
GR862249B (en) 1986-12-31
AU6216086A (en) 1987-03-05
KR870003071A (ko) 1987-04-14
EP0218068A1 (de) 1987-04-15
DK420986A (da) 1987-03-05

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