ES2001665A6 - Procedimiento para preparar tripeptidos alquilados en n - Google Patents

Procedimiento para preparar tripeptidos alquilados en n

Info

Publication number
ES2001665A6
ES2001665A6 ES8601664A ES8601664A ES2001665A6 ES 2001665 A6 ES2001665 A6 ES 2001665A6 ES 8601664 A ES8601664 A ES 8601664A ES 8601664 A ES8601664 A ES 8601664A ES 2001665 A6 ES2001665 A6 ES 2001665A6
Authority
ES
Spain
Prior art keywords
formula
radical
tripeptides
rented
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601664A
Other languages
English (en)
Inventor
Hansjorg Urbach
Rainer Henning
Reinhard Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2001665A6 publication Critical patent/ES2001665A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA I DONDE A SIGNIFICA EL RADICAL DE UN AMINOACIDO, R4, JUNTO CON R5 Y LOS ATOMOS QUE LOS LLEVAN, FORMAN UN SISTEMA DE ANILLOS HETEROCICLICOS, N ES 1 O 2 Y R, R1, R2 Y R3 SIGNIFICAN HIDROGENO O UN RADICAL DEFINIDO, HACIENDO REACCIONAR EN UN MEDIO ADECUADO UN COMPUESTO DE FORMULA II DONDE LOS SIMBOLOS SON COMO ANTES, CON UN ESTER DE AMINOACIDO DE FORMULA III R3OOC-A-NH2(III) DONDE A ES COMO ANTES Y R3 REPRESENTA UN GRUPO ESTERIFICADOR, SEPARANDOSE EVENTUALMENTE EL GRUPO PROTECTOR R3 Y ELIMINANDOSE EVENTUALMENTE EL RADICAL R2. EL INVENTO ABARCA OTRAS FASES DE OBTENCION DEL COMPUESTO DE FORMULA I QUE SE DESCRIBEN EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS SON ESPECIALMENTE UTILES COMO AGENTES HIPOTENSORES.
ES8601664A 1985-09-09 1986-09-05 Procedimiento para preparar tripeptidos alquilados en n Expired ES2001665A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853532035 DE3532035A1 (de) 1985-09-09 1985-09-09 Neue n-alkylierte tripeptide, verfahren zu ihrer herstellung, sie enthaltende medikamente und deren verwendung

Publications (1)

Publication Number Publication Date
ES2001665A6 true ES2001665A6 (es) 1988-06-01

Family

ID=6280419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601664A Expired ES2001665A6 (es) 1985-09-09 1986-09-05 Procedimiento para preparar tripeptidos alquilados en n

Country Status (13)

Country Link
EP (1) EP0214570A3 (es)
JP (1) JPS6261995A (es)
KR (1) KR870003134A (es)
AU (1) AU6243286A (es)
DE (1) DE3532035A1 (es)
DK (1) DK427786A (es)
ES (1) ES2001665A6 (es)
FI (1) FI863593A7 (es)
GR (1) GR862287B (es)
HU (1) HUT42507A (es)
IL (1) IL79966A0 (es)
PT (1) PT83323B (es)
ZA (1) ZA866807B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
BR112015022854A2 (pt) 2013-03-14 2017-07-18 Alkermes Pharma Ireland Ltd pró-farmacos de fumaratos e uso do mesmo no tratamento de várias doenças
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
JP6337135B2 (ja) 2014-02-24 2018-06-06 アルカーメス ファーマ アイルランド リミテッド フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz

Also Published As

Publication number Publication date
JPS6261995A (ja) 1987-03-18
EP0214570A2 (de) 1987-03-18
AU6243286A (en) 1987-03-12
FI863593A0 (fi) 1986-09-05
PT83323A (pt) 1986-10-01
DK427786A (da) 1987-03-10
ZA866807B (en) 1987-04-29
PT83323B (pt) 1989-05-12
EP0214570A3 (de) 1989-11-15
IL79966A0 (en) 1986-12-31
DK427786D0 (da) 1986-09-08
HUT42507A (en) 1987-07-28
KR870003134A (ko) 1987-04-15
DE3532035A1 (de) 1987-03-26
FI863593L (fi) 1987-03-10
GR862287B (en) 1987-01-12
FI863593A7 (fi) 1987-03-10

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-05

FD1A Patent lapsed

Effective date: 20000208