ES2001809A6 - Un procedimiento para la preparacion de nuevas 3-(4,-fenil-piperazinil)alquil-quinazolin-2,4-(1h,3h)-dionas sustituidas - Google Patents

Un procedimiento para la preparacion de nuevas 3-(4,-fenil-piperazinil)alquil-quinazolin-2,4-(1h,3h)-dionas sustituidas

Info

Publication number
ES2001809A6
ES2001809A6 ES8602281A ES8602281A ES2001809A6 ES 2001809 A6 ES2001809 A6 ES 2001809A6 ES 8602281 A ES8602281 A ES 8602281A ES 8602281 A ES8602281 A ES 8602281A ES 2001809 A6 ES2001809 A6 ES 2001809A6
Authority
ES
Spain
Prior art keywords
quinazolin
piperazinyl
alkyl
substituted
dionas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602281A
Other languages
English (en)
Inventor
Victor T Bandurco
Charles F Schwender
Robert Falotico
Alfonso J Tobia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES2001809A6 publication Critical patent/ES2001809A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS COMPONENTES DE FORMULA (I) DONDE X, R1, R2, R3, R4 Y R5 REPRESENTAN DIFERENTES RADICALES ORGANICOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SE OBTIENEN POR REACCION DE LOS COMPUESTOS (IV) Y (V). ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIHIPERTENSORES.
ES8602281A 1985-09-30 1986-09-29 Un procedimiento para la preparacion de nuevas 3-(4,-fenil-piperazinil)alquil-quinazolin-2,4-(1h,3h)-dionas sustituidas Expired ES2001809A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/782,241 US4711883A (en) 1985-09-30 1985-09-30 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use

Publications (1)

Publication Number Publication Date
ES2001809A6 true ES2001809A6 (es) 1988-06-16

Family

ID=25125457

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602281A Expired ES2001809A6 (es) 1985-09-30 1986-09-29 Un procedimiento para la preparacion de nuevas 3-(4,-fenil-piperazinil)alquil-quinazolin-2,4-(1h,3h)-dionas sustituidas

Country Status (15)

Country Link
US (1) US4711883A (es)
EP (1) EP0219259A3 (es)
JP (1) JPS62111970A (es)
KR (1) KR870003098A (es)
AU (1) AU583949B2 (es)
CA (1) CA1290334C (es)
DK (3) DK162988C (es)
ES (1) ES2001809A6 (es)
FI (1) FI863910L (es)
GR (1) GR862452B (es)
HU (1) HUT43590A (es)
IL (1) IL80184A0 (es)
NO (1) NO863870L (es)
PT (1) PT83458B (es)
ZA (1) ZA867424B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
PL165856B1 (pl) * 1990-04-24 1995-02-28 Dresden Arzneimittel Sposób wytwarzania nowych 3-/merkaptoalkilo/-chinazolino-/1 H,3H/-dionów-2,4 PL
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―１ｈ―퀴나졸린―２,４―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
PT2400968T (pt) 2009-02-26 2016-12-09 Reviva Pharmaceuticals Inc Composições, sintese e métodos de utilização dos derivados de arilpiperazína
EP3180318B1 (en) * 2014-08-11 2019-02-20 Hydra Biosciences, Inc. Quinazoline-2,4(1h,3h)-dione derivatives as trcp5 modulators for the treatment of neuropsychiatric disorders
CN111848528B (zh) * 2019-04-29 2022-03-11 北京嘉林药业股份有限公司 一种预防和/或治疗癌症的化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612466A (en) * 1966-05-26 1967-11-30 Miles Laboratories Inc. V Product and process
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
US4639518A (en) * 1984-09-24 1987-01-27 Ortho Pharmaceutical Corporation Substituted quinazolinediones

Also Published As

Publication number Publication date
ZA867424B (en) 1988-04-27
DK113591A (da) 1991-06-13
DK465086D0 (da) 1986-09-29
DK109891A (da) 1991-06-10
IL80184A0 (en) 1986-12-31
AU583949B2 (en) 1989-05-11
HUT43590A (en) 1987-11-30
EP0219259A2 (en) 1987-04-22
DK162988B (da) 1992-01-06
US4711883A (en) 1987-12-08
NO863870L (no) 1987-03-31
EP0219259A3 (en) 1988-01-20
FI863910A0 (fi) 1986-09-29
GR862452B (en) 1987-01-27
PT83458A (en) 1986-10-01
DK113591D0 (da) 1991-06-13
PT83458B (en) 1988-10-31
FI863910A7 (fi) 1987-03-31
JPS62111970A (ja) 1987-05-22
CA1290334C (en) 1991-10-08
DK465086A (da) 1987-03-31
FI863910L (fi) 1987-03-31
DK162988C (da) 1992-06-01
KR870003098A (ko) 1987-04-15
AU6321186A (en) 1987-04-02
DK109891D0 (da) 1991-06-10
NO863870D0 (no) 1986-09-29

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-29