ES2002038A6 - Procedimiento para preparar quinolinas-2-sustituidas. - Google Patents
Procedimiento para preparar quinolinas-2-sustituidas.Info
- Publication number
- ES2002038A6 ES2002038A6 ES8602616A ES8602616A ES2002038A6 ES 2002038 A6 ES2002038 A6 ES 2002038A6 ES 8602616 A ES8602616 A ES 8602616A ES 8602616 A ES8602616 A ES 8602616A ES 2002038 A6 ES2002038 A6 ES 2002038A6
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- benzyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-Substituted quinolines Chemical class 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002617 leukotrienes Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE QUINOLINAS-2-SUSTITUIDAS DE FORMULA (I), DONDE R1 ES H, HALOGENO, ALQUILO C1-8, ALQUENILO O ALQUINILO C2-8, -CF3, -OR2, -SR2, -SOR2, -SO2R2, -NR2R2, -CHO, -COOR2, -(CFO)R2, -CN, -C(OH)R2R2, -NO2, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO C1-8, ALQUENILO O ALQUINILO C2-8, -CF3, FENILO, BENCILO O FENETILO OPCIONALMENTE SUSTITUIDOS; R3 ES -(A)M-(CR2R2)M-(CR2R4)M-CR2R42, NO SIENDO -CHO CUANDO R3 ESTA EN POSICION <PARA> RESPECTO A Y; R4 ES H, HALOGENO, -NO2, -OR2, -SR2, -NR2R2 O ALQUILO C1-8, O R42 PUEDE SER FO; A ES FCFO O CR2(OR6); M ES 0-8 E Y ES -CHFCH-. SE OBTIENEN POR CONDENSACION DE UNA QUINOLINA III CON UN DIALDEHIDO VI Y POSTERIOR REACCION CON UN REACTIVO CARBANIONICO SELECCIONADO ENTRE UN REACTIVO DE GRIGNARD O UN REACTIVO DE ALQUIL-LITIO. LOS COMPUETOS 1 ASI OBTENIDOS SON ANTAGONISTAS DE LEUCOTRIENIOS E INHIBEN SU BIOSINTESIS. SON UTILES COMO AGENTES ANTIASMATICOS, ANTIALERGICOS, ANTIINFLAMATORIOS Y CITO-PROTECTORES. 3
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78818085A | 1985-10-16 | 1985-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2002038A6 true ES2002038A6 (es) | 1988-07-01 |
Family
ID=25143689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8602616A Expired ES2002038A6 (es) | 1985-10-16 | 1986-10-15 | Procedimiento para preparar quinolinas-2-sustituidas. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0219307A3 (es) |
| JP (1) | JPS6293276A (es) |
| DK (1) | DK487686A (es) |
| ES (1) | ES2002038A6 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO174506B (no) * | 1984-10-30 | 1994-02-07 | Usv Pharma Corp | Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser |
| EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
| GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
| US5232916A (en) * | 1988-06-27 | 1993-08-03 | Merck Frosst Canada, Inc. | Quinoline ether alkanoic acids |
| US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
| US5508408A (en) * | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
| EP0725063A1 (de) * | 1995-02-01 | 1996-08-07 | Ciba-Geigy Ag | Chinolin-Derivate |
| FR2761687B1 (fr) * | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
| NO174506B (no) * | 1984-10-30 | 1994-02-07 | Usv Pharma Corp | Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser |
-
1986
- 1986-10-08 EP EP86307779A patent/EP0219307A3/en not_active Withdrawn
- 1986-10-13 DK DK487686A patent/DK487686A/da not_active Application Discontinuation
- 1986-10-15 ES ES8602616A patent/ES2002038A6/es not_active Expired
- 1986-10-16 JP JP61244300A patent/JPS6293276A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0219307A2 (en) | 1987-04-22 |
| DK487686A (da) | 1987-04-17 |
| DK487686D0 (da) | 1986-10-13 |
| JPS6293276A (ja) | 1987-04-28 |
| EP0219307A3 (en) | 1987-10-14 |
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