ES2003086A6 - Procedimiento de obtencion de tienoquinolicinsulfonamidas - Google Patents

Procedimiento de obtencion de tienoquinolicinsulfonamidas

Info

Publication number
ES2003086A6
ES2003086A6 ES8600954A ES8600954A ES2003086A6 ES 2003086 A6 ES2003086 A6 ES 2003086A6 ES 8600954 A ES8600954 A ES 8600954A ES 8600954 A ES8600954 A ES 8600954A ES 2003086 A6 ES2003086 A6 ES 2003086A6
Authority
ES
Spain
Prior art keywords
lower alkyl
alkyl
hydrogen
different
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600954A
Other languages
English (en)
Inventor
Terence James Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858520151A external-priority patent/GB8520151D0/en
Priority claimed from GB868605923A external-priority patent/GB8605923D0/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of ES2003086A6 publication Critical patent/ES2003086A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE TIENO QUINOLICINSULFONAMIDAS, DE FORMULA GENERAL (I) EN DONDE R REPRESENTA HIDROGENO O ALQUILO INFERIOR R1 Y R2 REPRESENTAN CADA UNO HIDROGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR O HALOGENO, R3 Y R4 REPRESENTAN CADA UNO ALQUILO INFERIOR, HALO (INFERIOR) ALQUILO O ARILO, A REPRESENTA UN GRUPO ALQUILENO INFERIOR CON 1 A 3 CARBONOS EN LA CADENA ENTRE LOS DOS ATOMOS DE N, Y X REPRESENTA O, S, O NR5 (DONDE R5 ES HIDROGENO O ALQUILO INFERIOR). EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN DERIVADO REACTIVO DE UN ACIDO SULFONICO, DE FORMULA (II) (EN DONDE R6 TIENE EL SIGNIFICADO DE R3 Y R4 ANTES INDICADO), CON UNA QUINOLICINA DE FORMULA (III), (VIII) O (IX), (EN DONDE X, R, R1, R2 Y R3 Y R4 TIENEN EL SIGNIFICADO DADO ANTERIORMENTE). LA REACCION SE LLEVA A CABO GENERALMENTE BAJO CONDICIONES BASICAS. ESTOS PRODUCTOS PUEDEN USARSE PARA PREPARAR COMPOSICIONES FARMACEUTICAS QUE TIENEN ACTIVIDAD ALFA2©ADRENOCEPTORA ANTAGONISTICA.
ES8600954A 1985-08-10 1986-08-08 Procedimiento de obtencion de tienoquinolicinsulfonamidas Expired ES2003086A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520151A GB8520151D0 (en) 1985-08-10 1985-08-10 Sulphonamides
GB868605923A GB8605923D0 (en) 1986-03-11 1986-03-11 Sulphonamides

Publications (1)

Publication Number Publication Date
ES2003086A6 true ES2003086A6 (es) 1988-10-16

Family

ID=26289643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600954A Expired ES2003086A6 (es) 1985-08-10 1986-08-08 Procedimiento de obtencion de tienoquinolicinsulfonamidas

Country Status (14)

Country Link
US (1) US4788202A (es)
EP (1) EP0213793B1 (es)
JP (1) JPH0684374B2 (es)
KR (1) KR940006630B1 (es)
AU (1) AU582663B2 (es)
CA (1) CA1308720C (es)
DE (1) DE3684384D1 (es)
DK (1) DK161329C (es)
ES (1) ES2003086A6 (es)
GB (1) GB2178741B (es)
GR (1) GR862077B (es)
HU (1) HU198055B (es)
IE (1) IE59304B1 (es)
PT (1) PT83154B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW17385A1 (en) * 1984-11-06 1986-02-19 Hoffmann La Roche Tricyclic pyridine derivatives
US4831035A (en) * 1986-08-28 1989-05-16 Merck & Co., Inc. Substituted hexahydroarylquinolizines
US4923878A (en) * 1988-11-14 1990-05-08 Merck & Co., Inc. Quinolizine sulfonamides used against certain neoplastic disease states
US4968692A (en) * 1989-01-06 1990-11-06 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Attenuation of ethyl alcohol intoxication with alpha-2 adrenoceptor antagonists
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
EA008537B1 (ru) 2002-04-03 2007-06-29 Орион Корпорейшн Полициклические соединения как эффективные антагонисты альфа2-адренорецептора
KR101002582B1 (ko) 2008-09-27 2010-12-20 주식회사 오토닉스 위상 제어 및 제로크로스 사이클 제어 기능을 갖는 온도조절기

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2075973B (en) * 1980-05-09 1983-10-05 Wyeth John & Brother Ltd Indoloquinolizines
EP0089926A3 (de) * 1982-03-24 1984-05-16 Ciba-Geigy Ag Pharmazeutische Präparate enthaltend stickstoffhaltige Tetracyclen sowie neue Verbindungen dieser Art
IE57014B1 (en) * 1983-03-25 1992-03-11 Wyeth John & Brother Ltd Benzoquinolizines
US4690928A (en) * 1984-02-02 1987-09-01 Merck & Co., Inc. Substituted hexahydro arylquinolizines as α2 blockers
ES8609323A1 (es) * 1984-02-02 1986-07-16 Merck & Co Inc Un procedimiento para la preparacion de hexahidro-arilquinolizinas sustituidas.
GB8420602D0 (en) * 1984-08-14 1984-09-19 Wyeth John & Brother Ltd Thienoquinolizines
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines

Also Published As

Publication number Publication date
AU582663B2 (en) 1989-04-06
DK161329C (da) 1992-01-06
GB8619155D0 (en) 1986-09-17
US4788202A (en) 1988-11-29
EP0213793B1 (en) 1992-03-18
JPH0684374B2 (ja) 1994-10-26
CA1308720C (en) 1992-10-13
HUT45054A (en) 1988-05-30
KR940006630B1 (ko) 1994-07-23
PT83154A (en) 1986-09-01
IE862138L (en) 1987-02-10
DK380286A (da) 1987-02-11
PT83154B (pt) 1989-03-30
GB2178741B (en) 1989-01-11
EP0213793A2 (en) 1987-03-11
DE3684384D1 (en) 1992-04-23
DK161329B (da) 1991-06-24
HU198055B (en) 1989-07-28
EP0213793A3 (en) 1988-03-30
DK380286D0 (da) 1986-08-08
IE59304B1 (en) 1994-02-09
GB2178741A (en) 1987-02-18
JPS6239586A (ja) 1987-02-20
AU6080486A (en) 1987-02-12
GR862077B (en) 1986-12-24
KR870002144A (ko) 1987-03-30

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