ES2002158A6 - Un procedimiento para prepara nuevos peptidos ciclicos - Google Patents
Un procedimiento para prepara nuevos peptidos ciclicosInfo
- Publication number
- ES2002158A6 ES2002158A6 ES8601950A ES8601950A ES2002158A6 ES 2002158 A6 ES2002158 A6 ES 2002158A6 ES 8601950 A ES8601950 A ES 8601950A ES 8601950 A ES8601950 A ES 8601950A ES 2002158 A6 ES2002158 A6 ES 2002158A6
- Authority
- ES
- Spain
- Prior art keywords
- unit
- vasopressin
- vasopr
- essin
- vsp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical class C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
- 108010004977 Vasopressins Proteins 0.000 abstract 1
- 102000002852 Vasopressins Human genes 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 238000007243 oxidative cyclization reaction Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
- 229960003726 vasopressin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/15—Oxytocin or vasopressin; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR NUEVOS PEPTIDOS CICLICOS DE FORMULA: DONDE MPR ES UN RESTO DE ACIDO B-MERCAPTOPROPIONICO, X Y B SON ISOMEROS DE AMINOACIDOS, A ES PRO O UN ENLACE SIMPLE, C ES UN ISOMERO DE AMINOACIDO O UN ENLACE SIMPLE E Y ES OH O NH2, EN EL QUE SE CICLIZA UN PEPTIDO LINEAL DE FORMULA: DONDE X,A,B,C E Y SON COMO ANTES, Y, OPCIONALMENTE, SE SEPARAN TODOS LOS GRUPOS PROTECTORES, SE INTRODUCE EL GRUPO B Y SE FORMAN SALES O ESTERES FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS OBTENIDOS TIENEN ACTIVIDAD ANTAGONISTA V1-V2 DE LA VASOPRESINA Y SON UTILES PARA TRATAR HIPERTENSION, CIRROSIS HEPATICA, FALLO CONGESTIVO CARDIACO Y ESTADOS TRAUMATICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/777,385 US4711877A (en) | 1985-09-18 | 1985-09-18 | 6-pen-vasopressin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2002158A6 true ES2002158A6 (es) | 1988-07-16 |
Family
ID=25110112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8601950A Expired ES2002158A6 (es) | 1985-09-18 | 1986-09-17 | Un procedimiento para prepara nuevos peptidos ciclicos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4711877A (es) |
| EP (1) | EP0216606A3 (es) |
| JP (1) | JPS6267100A (es) |
| AU (1) | AU597271B2 (es) |
| DK (1) | DK443686A (es) |
| ES (1) | ES2002158A6 (es) |
| GR (1) | GR862362B (es) |
| PT (1) | PT83384B (es) |
| ZA (1) | ZA867064B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5373089A (en) * | 1988-09-02 | 1994-12-13 | Northwestern University | Oxytocin antagonist |
| US6828415B2 (en) | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| SI0698041T1 (en) * | 1993-05-19 | 1998-02-28 | Biosearch Italia S.P.A. | Synthetic aglucodalbaheptide antibiotics |
| US20110313846A1 (en) * | 2010-06-16 | 2011-12-22 | Microsoft Corporation | Including personalized content in an advertisement |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH495957A (de) * | 1966-09-15 | 1970-09-15 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids |
| CA1246055A (en) * | 1980-03-24 | 1988-12-06 | Joseph H. Cort | N-.omega.-substituted hormonogens of vasopressin and its synthetic analogs |
| US4367225A (en) * | 1981-03-24 | 1983-01-04 | The Medical College Of Ohio | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin |
| US4491577A (en) * | 1981-11-16 | 1985-01-01 | The Medical College Of Ohio | Antagonists of the antidiuretic action of arginine vasopressin |
| DK153883A (da) * | 1982-04-20 | 1983-10-21 | Ceskoslovenska Akademie Ved | Vasopressin-analoge |
| DK233183A (da) * | 1982-06-03 | 1983-12-04 | Ceskoslovenska Akademie Ved | Analoge af neurohypofysiske hormoner med haemmende effekt |
| US4504469A (en) * | 1982-12-21 | 1985-03-12 | Ferring Ab | Vasotocin derivatives |
| US4469679A (en) * | 1983-02-16 | 1984-09-04 | Smithkline Beckman Corporation | Octapeptide vasopressin antagonists |
| US4469680A (en) * | 1983-07-06 | 1984-09-04 | Smithkline Beckman Corporation | Iodinated vasopressin antagonists |
| US4481194A (en) * | 1984-03-07 | 1984-11-06 | Smithkline Beckman Corporation | Des-proline-des-glycine vasopressin antagonists |
-
1985
- 1985-09-18 US US06/777,385 patent/US4711877A/en not_active Expired - Fee Related
-
1986
- 1986-09-15 AU AU62675/86A patent/AU597271B2/en not_active Expired - Fee Related
- 1986-09-16 DK DK443686A patent/DK443686A/da not_active Application Discontinuation
- 1986-09-16 PT PT83384A patent/PT83384B/pt unknown
- 1986-09-16 GR GR862362A patent/GR862362B/el unknown
- 1986-09-17 ZA ZA867064A patent/ZA867064B/xx unknown
- 1986-09-17 ES ES8601950A patent/ES2002158A6/es not_active Expired
- 1986-09-18 JP JP61221766A patent/JPS6267100A/ja active Pending
- 1986-09-18 EP EP86307204A patent/EP0216606A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU597271B2 (en) | 1990-05-31 |
| PT83384A (en) | 1986-10-01 |
| US4711877A (en) | 1987-12-08 |
| EP0216606A2 (en) | 1987-04-01 |
| PT83384B (en) | 1988-10-24 |
| ZA867064B (en) | 1987-08-26 |
| GR862362B (en) | 1987-01-16 |
| AU6267586A (en) | 1987-03-26 |
| JPS6267100A (ja) | 1987-03-26 |
| DK443686A (da) | 1987-03-19 |
| DK443686D0 (da) | 1986-09-16 |
| EP0216606A3 (en) | 1989-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001204 |