ES2002416A6 - Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metilindoles) - Google Patents
Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metilindoles)Info
- Publication number
- ES2002416A6 ES2002416A6 ES8602588A ES8602588A ES2002416A6 ES 2002416 A6 ES2002416 A6 ES 2002416A6 ES 8602588 A ES8602588 A ES 8602588A ES 8602588 A ES8602588 A ES 8602588A ES 2002416 A6 ES2002416 A6 ES 2002416A6
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- derivs
- amino
- indole
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 methyl methyl indole Chemical compound 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- WZOLWRDMIGNLTK-UHFFFAOYSA-N 1,3-dimethylindol-2-amine Chemical compound NC=1N(C2=CC=CC=C2C1C)C WZOLWRDMIGNLTK-UHFFFAOYSA-N 0.000 abstract 1
- BLRHMMGNCXNXJL-UHFFFAOYSA-N 1-methylindole Chemical class C1=CC=C2N(C)C=CC2=C1 BLRHMMGNCXNXJL-UHFFFAOYSA-N 0.000 abstract 1
- MAHAMBLNIDMREX-UHFFFAOYSA-N 1-methylindole-2-carboxylic acid Chemical class C1=CC=C2N(C)C(C(O)=O)=CC2=C1 MAHAMBLNIDMREX-UHFFFAOYSA-N 0.000 abstract 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- SLNVSARGOSPIPA-UHFFFAOYSA-N 4-bromobuta-1,2-diene Chemical compound BrCC=C=C SLNVSARGOSPIPA-UHFFFAOYSA-N 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910000103 lithium hydride Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO NUEVO PARA LA PREPARACION DE DERIVADOS ACETILENICOS Y ALENICOS DE 2-AMINOMETIL-(1-METILINDOLES). SE PARTE DE LOS CORRESPONDIENTES ACIDOS 1-METILINDOL-2-CARBOXILICOS QUE POR REACCION PREFERENTEMENTE CON PENTACLORURO DE FOSFORO EN ETER SE TRANSFORMA EN EL CORRESPONDIENTE CLORURO DE ACIDO, EL CUAL TRATADO CON AMONIACO O AMINAS CONDUCE A LAS RESPECTIVAS AMIDAS. LAS AMIDAS SE REDUCEN CON HIDRURO DE LITIO Y ALUMINIO, PREFERENTEMENTE EN TETRAHIDROFURANO A REFLUJO PARA DAR LAS CORRESPONDIENTES 2-AMINOMETIL-1(1-METILINDOLES), QUE SE ACILAN Y CARACTERIZAN COMO BASES LIBRES O ALGUNA DE SUS SALES, GENERALMENTE HIDROCLORUROS. FINALMENTE ESTAS AMINAS SE HACEN REACCIONAR CON LOS BROMUROS DE 2-PROPINILO, DE 2-BUTINILO Y DE 2,3-BUTADIENILO, EN PRESENCIA DE TERC-BUTILAMINA PARA DAR LOS N-(2-PROPINIL) N-(2-BUTINIL) Y N-(2,3-BUTADIENIL) DERIVADOS DE LOS RESPECTIVOS 2-AMINO METIL-(1-METILINDOLES) QUE SE CARACTERIZAN COMO BASES LIBRES O COMO ALGUNA DE SUS SALES. LOS COMPUESTOS FINALES OBTENIDOS SON ACTIVOS COMO INHIBIDORES DE MONOANIURO OXIDASAS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8602588A ES2002416A6 (es) | 1986-10-14 | 1986-10-14 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metilindoles) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8602588A ES2002416A6 (es) | 1986-10-14 | 1986-10-14 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metilindoles) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2002416A6 true ES2002416A6 (es) | 1988-08-01 |
Family
ID=8248579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8602588A Expired ES2002416A6 (es) | 1986-10-14 | 1986-10-14 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metilindoles) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2002416A6 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003534324A (ja) * | 2000-05-24 | 2003-11-18 | サントル ナシオナル ドゥ ラ ルシェルシュ シアンティフィーク（セーエヌエールエス） | 新規カルシウム受容体活性分子およびその製造方法 |
| CN104098479A (zh) * | 2014-07-28 | 2014-10-15 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
-
1986
- 1986-10-14 ES ES8602588A patent/ES2002416A6/es not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003534324A (ja) * | 2000-05-24 | 2003-11-18 | サントル ナシオナル ドゥ ラ ルシェルシュ シアンティフィーク（セーエヌエールエス） | 新規カルシウム受容体活性分子およびその製造方法 |
| CN104098479A (zh) * | 2014-07-28 | 2014-10-15 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
| CN104098479B (zh) * | 2014-07-28 | 2016-02-10 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
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