ES2010406A6 - Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metil-indoles). - Google Patents
Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metil-indoles).Info
- Publication number
- ES2010406A6 ES2010406A6 ES8900562A ES8900562A ES2010406A6 ES 2010406 A6 ES2010406 A6 ES 2010406A6 ES 8900562 A ES8900562 A ES 8900562A ES 8900562 A ES8900562 A ES 8900562A ES 2010406 A6 ES2010406 A6 ES 2010406A6
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- derivs
- methyl indole
- alenic
- prepn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DPUGCFBTWBSNDC-UHFFFAOYSA-N 2,3-dimethyl-1h-indol-4-amine Chemical compound C1=CC(N)=C2C(C)=C(C)NC2=C1 DPUGCFBTWBSNDC-UHFFFAOYSA-N 0.000 title 1
- BJLPAXGOFMVSJE-UHFFFAOYSA-N (1-methylindol-2-yl)methanamine Chemical compound C1=CC=C2N(C)C(CN)=CC2=C1 BJLPAXGOFMVSJE-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- MAHAMBLNIDMREX-UHFFFAOYSA-N 1-methylindole-2-carboxylic acid Chemical class C1=CC=C2N(C)C(C(O)=O)=CC2=C1 MAHAMBLNIDMREX-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- SLNVSARGOSPIPA-UHFFFAOYSA-N 4-bromobuta-1,2-diene Chemical compound BrCC=C=C SLNVSARGOSPIPA-UHFFFAOYSA-N 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229910000103 lithium hydride Inorganic materials 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO NUEVO PARA LA PREPARACION DE DERIVADOS ACETILENICOS Y ALENICOS DE 2-AMINOMETIL-(1-METILINDOLES). SE PARTE DE LOS CORRESPONDIENTES ACIDOS 1-METILINDOL-2-CARBOXILICOS QUE POR REACCION PREFERENTEMENTE CON PENTACLORURO DE FOSFORO EN ETER SE TRANSFORMA EN EL CORRESPONDIENTE CLORURO DE ACIDO, EL CUAL TRATADO CON AMONIACO O AMINAS CONDUCE A LAS RESPECTIVAS AMIDAS. LAS AMIDAS SE REDUCEN CON HIDRURO DE LITIO Y ALUMINIO, PREFERENTEMENTE EN TETRAHIDROFURANO A REFLUJO PARA DAR LAS CORRESPONDIENTES 2-AMINMETIL-(1-METILINDOLES), QUE SE ACILAN Y CARACTERIZAN COMO BASES LIBRES O ALGUNA DE SUS SALES, GENERALMENTE HIDROCLORUROS. FINALMENTE ESTAS AMINAS SE HACEN REACCIONAR LOS BROMUROS DE 2-PROPINILO, DE 2-BUTINILO Y DE 2,3-BUTADIENILO, EN PRESENCIA DE TERC-BUTILAMINA PARA DAR LOS N-(2-PROPINIL) N-(2-BUTINIL) Y N-(2,3-BUTADIENIL) DERIVADOS DE LOS RESPECTIVOS 2-AMINOMETIL-(1-METILINDOLES) QUESE CARACTERIZAN COMO BASES LIBRES O COMO ALGUNA DE SUS SALES. LOS COMPUESTOS FINALES OBTENIDOS SON ACTIVOS COMO INHIBIDORES DE MONOANIURO OXIDASAS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8900562A ES2010406A6 (es) | 1989-02-16 | 1989-02-16 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metil-indoles). |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8900562A ES2010406A6 (es) | 1989-02-16 | 1989-02-16 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metil-indoles). |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2010406A6 true ES2010406A6 (es) | 1989-11-01 |
Family
ID=8260450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8900562A Expired ES2010406A6 (es) | 1989-02-16 | 1989-02-16 | Procedimiento para la obtencion de derivados acetilenicos y alenicos de 2-aminometil-(1-metil-indoles). |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2010406A6 (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001090069A1 (fr) * | 2000-05-24 | 2001-11-29 | Centre National De La Recherche Scientifique (Cnrs) | Composes possedant une activite calcimimetique |
| CN104098479A (zh) * | 2014-07-28 | 2014-10-15 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
-
1989
- 1989-02-16 ES ES8900562A patent/ES2010406A6/es not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001090069A1 (fr) * | 2000-05-24 | 2001-11-29 | Centre National De La Recherche Scientifique (Cnrs) | Composes possedant une activite calcimimetique |
| FR2809396A1 (fr) * | 2000-05-24 | 2001-11-30 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
| JP2003534324A (ja) * | 2000-05-24 | 2003-11-18 | サントル ナシオナル ドゥ ラ ルシェルシュ シアンティフィーク（セーエヌエールエス） | 新規カルシウム受容体活性分子およびその製造方法 |
| US7084167B2 (en) | 2000-05-24 | 2006-08-01 | Centre National De La Rechereche Scientifique (Cnrs) | Calcium receptor active molecules and method for preparing same |
| CN104098479A (zh) * | 2014-07-28 | 2014-10-15 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
| CN104098479B (zh) * | 2014-07-28 | 2016-02-10 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041102 |