ES2003180A6 - A METHOD TO PREPARE A POLYPEPTIDE CAPABLE OF MODULATING THE ACTIVITY OF GROWTH. - Google Patents

A METHOD TO PREPARE A POLYPEPTIDE CAPABLE OF MODULATING THE ACTIVITY OF GROWTH.

Info

Publication number
ES2003180A6
ES2003180A6 ES8603468A ES8603468A ES2003180A6 ES 2003180 A6 ES2003180 A6 ES 2003180A6 ES 8603468 A ES8603468 A ES 8603468A ES 8603468 A ES8603468 A ES 8603468A ES 2003180 A6 ES2003180 A6 ES 2003180A6
Authority
ES
Spain
Prior art keywords
polypeptide
cells
proliferation
growth
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603468A
Other languages
Spanish (es)
Inventor
Joyce M Zarling
Mohammed Shoyab
Hans Marquardt
Marcia B Hanson
Mario N Lioubin
Thomas Joseph Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES2003180A6 publication Critical patent/ES2003180A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

EL POLIPEPTIDO TIENE UNA SECUENCIA DE AMINOACIDOS COMPRENDIDA EN, AL MENOS, UNA DE LAS SECUENCIAS A, B O C, Y DA REACCION CRUZADA CON UN POLIPEPTIDO ENCONTRADO EN LINFOCITOS DE SANGRE PERIFERICO HUMANA NORMAL ACTIVADOS POR UN MITOGENO. EL METODO COMPRENDE EL CULTIVO DE CELULAS QUE EXPRESAN DICHA SECUENCIA DE DNA EN UN MEDIO ADECUADO DE CRECIMIENTO; SEPARACION DE DICHAS CELULAS DEL MEDIO DE CRECIMIENTO Y AISLAMIENTO DE POLIPEPTIDO. ALTERNATIVAMENTE, EL POLIPEPTIDO PUEDE SER SINTETIZADO O PREPARADO POR CLONAJE DE GEN EN UN HUESPED APROPIADO. EL POLIPEPTIDO ASI OBTENIDO ES CAPAZ DE INHIBIR LA PROLIFERACION DE CIERTAS CELULAS NEOPLASICAS Y DE ESTIMULAR LA PROLIFERACION DE CIERTAS LINEAS CELULARES TALES COMO FIBROPLASTOS, POR LO QUE ES UTIL PARA EL TRATAMIENTO O DIAGNOSTICO DEL CANCER Y COMO INMONOMODULADOR EN EL TRATAMIENTO DE PACIENTES CON INMUNO DEFICIENCIAS Y SIMILARES.THE POLYPEPTIDE HAS AN AMINO ACID SEQUENCE INCLUDING IN AT LEAST ONE OF THE SEQUENCES A, B OR C, AND GIVES CROSS REACTION WITH A POLYPEPTIDE FOUND IN NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES ACTIVATED BY A MITOGEN. THE METHOD INCLUDES THE CULTIVATION OF CELLS THAT EXPRESS SUCH DNA SEQUENCE IN AN ADEQUATE GROWTH MEDIUM; SEPARATION OF SUCH CELLS FROM THE GROWTH MEDIA AND ISOLATION OF POLYPEPTIDE. ALTERNATIVELY, THE POLYPEPTIDE MAY BE SYNTHESIZED OR PREPARED BY A CLONE OF GENE IN AN APPROPRIATE GUEST. THE POLYPEPTIDE SO OBTAINED IS CAPABLE OF INHIBITING THE PROLIFERATION OF CERTAIN NEOPLASTIC CELLS AND OF STIMULATING THE PROLIFERATION OF CERTAIN CELL LINES SUCH AS FIBROPLASTS, SO IT IS USEFUL FOR THE TREATMENT OR DIAGNOSIS OF CANCER AND INMATE AND SIMILAR.

ES8603468A 1985-12-20 1986-12-17 A METHOD TO PREPARE A POLYPEPTIDE CAPABLE OF MODULATING THE ACTIVITY OF GROWTH. Expired ES2003180A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81123585A 1985-12-20 1985-12-20
US93528386A 1986-11-26 1986-11-26

Publications (1)

Publication Number Publication Date
ES2003180A6 true ES2003180A6 (en) 1988-10-16

Family

ID=27123452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603468A Expired ES2003180A6 (en) 1985-12-20 1986-12-17 A METHOD TO PREPARE A POLYPEPTIDE CAPABLE OF MODULATING THE ACTIVITY OF GROWTH.

Country Status (29)

Country Link
JP (1) JP2559035B2 (en)
KR (1) KR920005920B1 (en)
CN (1) CN1017626B (en)
AT (1) AT400444B (en)
AU (2) AU601168B2 (en)
BE (1) BE905957A (en)
CA (1) CA1340296C (en)
CH (1) CH675727A5 (en)
CY (1) CY1608A (en)
DE (2) DE3645095C2 (en)
DK (1) DK174094B1 (en)
ES (1) ES2003180A6 (en)
FI (1) FI91484C (en)
FR (1) FR2597108B1 (en)
GB (1) GB2185485B (en)
GR (1) GR862936B (en)
HK (1) HK65691A (en)
HU (1) HU210694B (en)
IE (1) IE59415B1 (en)
IL (1) IL81017A (en)
IT (1) IT1213428B (en)
LU (1) LU86718A1 (en)
NL (1) NL8603209A (en)
NO (1) NO174556C (en)
NZ (1) NZ218634A (en)
OA (1) OA08494A (en)
PT (1) PT83986B (en)
SE (1) SE505059C2 (en)
SG (1) SG60891G (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645828A (en) * 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
NZ218634A (en) * 1985-12-20 1991-06-25 Oncogen Peptide identified by its cross reactivity with a cell growth factor, dna, antibodies to peptide and test kits
US5681930A (en) * 1985-12-20 1997-10-28 Bristol-Myers Squibb Company Anti-oncostatin M monoclonal antibodies
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
IL97622A (en) * 1990-03-29 1997-06-10 Oncogen Limited Partnership Se Monoclonal antibodies that inhibit growth of kaposi's sarcoma
IL97623A (en) * 1990-03-29 1996-01-19 Bristol Myers Squibb Co Anti-oncostatin m monoclonal antibodies their preparation and pharmaceutical compositions containing them
WO1992002556A1 (en) * 1990-08-02 1992-02-20 Michael Valentine Agrez Human colon cancer cell-derived fibroblast elongation factor
ZA936925B (en) * 1992-09-25 1995-03-20 Lilly Co Eli Modified platelet factor-4.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132776A (en) * 1978-02-15 1979-01-02 University Patents, Inc. Delivery of immunologically active components of transfer factor
US4645828A (en) * 1984-03-23 1987-02-24 Oncogen Platelet related growth regulator
NZ218634A (en) * 1985-12-20 1991-06-25 Oncogen Peptide identified by its cross reactivity with a cell growth factor, dna, antibodies to peptide and test kits

Also Published As

Publication number Publication date
SG60891G (en) 1991-08-23
NO865178L (en) 1987-06-22
KR870005645A (en) 1987-07-06
IE59415B1 (en) 1994-02-23
GB2185485B (en) 1990-07-04
PT83986A (en) 1987-01-01
CA1340296C (en) 1998-12-29
JPS62236498A (en) 1987-10-16
DE3643428A1 (en) 1987-09-24
DK615386D0 (en) 1986-12-18
AT400444B (en) 1995-12-27
JP2559035B2 (en) 1996-11-27
DK615386A (en) 1987-06-21
AU6660886A (en) 1987-06-25
GB2185485A (en) 1987-07-22
NZ218634A (en) 1991-06-25
NL8603209A (en) 1987-07-16
FI865156A0 (en) 1986-12-17
HU210694B (en) 1995-06-28
IE863345L (en) 1987-06-20
FI91484C (en) 1994-07-11
HK65691A (en) 1991-08-23
GR862936B (en) 1987-10-28
IL81017A0 (en) 1987-03-31
LU86718A1 (en) 1988-07-14
OA08494A (en) 1988-07-29
NO174556B (en) 1994-02-14
BE905957A (en) 1987-06-17
CY1608A (en) 1992-04-03
SE8605459L (en) 1987-06-21
ATA340686A (en) 1995-05-15
FI91484B (en) 1994-03-31
FR2597108B1 (en) 1991-02-15
AU639048B2 (en) 1993-07-15
CH675727A5 (en) 1990-10-31
FR2597108A1 (en) 1987-10-16
DK174094B1 (en) 2002-06-10
HUT43103A (en) 1987-09-28
IT1213428B (en) 1989-12-20
IT8622787A0 (en) 1986-12-19
KR920005920B1 (en) 1992-07-24
IL81017A (en) 1993-01-14
NO174556C (en) 1994-05-25
PT83986B (en) 1989-07-31
GB8629997D0 (en) 1987-01-28
SE8605459D0 (en) 1986-12-18
AU6776590A (en) 1991-03-14
NO865178D0 (en) 1986-12-19
AU601168B2 (en) 1990-09-06
FI865156L (en) 1987-06-21
CN86108955A (en) 1987-12-02
DE3643428C2 (en) 1990-08-23
DE3645095C2 (en) 1993-11-18
CN1017626B (en) 1992-07-29
SE505059C2 (en) 1997-06-16

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-12-17

FD1A Patent lapsed

Effective date: 20061218