ES2005492A6 - Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). - Google Patents

Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Info

Publication number
ES2005492A6
ES2005492A6 ES8703715A ES8703715A ES2005492A6 ES 2005492 A6 ES2005492 A6 ES 2005492A6 ES 8703715 A ES8703715 A ES 8703715A ES 8703715 A ES8703715 A ES 8703715A ES 2005492 A6 ES2005492 A6 ES 2005492A6
Authority
ES
Spain
Prior art keywords
hydroxy
formamide
deriv
prepn
hydroxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703715A
Other languages
English (en)
Inventor
Sole Luis Borras
Caballero Fernando A Geijo
Calahorra Francisco Lopez
Plana Jose Maria Valles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lasa Laboratorios SA
Original Assignee
Lasa Laboratorios SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lasa Laboratorios SA filed Critical Lasa Laboratorios SA
Priority to ES8703715A priority Critical patent/ES2005492A6/es
Publication of ES2005492A6 publication Critical patent/ES2005492A6/es
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL PRODUCTO N-[2-HIDROXI-5-[1-HIDROXI-2-[[2-(4-METOXIFENIL)-1-METIL-ETIL]AMINO]ETIL]FENIL] FORMAMIDA (I), GENERALMENTE ADMINISTRADO COMO SEMIFUMARATO DE DIASTEROISOMERO (R*, R*)-(+), POSEE UNA CONSIDERABLE ACTIVIDAD ESTIMULANTE A-ADRENERGICO, LO QUE LO CONVIERTE EN POTENCIALMENTE UTIL EN TERAPEUTICA COMO BRONCODILATADOR, ANTIALERGICO, ANTIASMATICO, ETC. EL OBJETO DE ESTA INVENCION ES UN NUEVO PROCEDIMIENTO DE OBTENCION DE (I) CARACTERIZADO PORQUE UN 4-GP-OXI-3-(N-FORMILAMINO)FENILOXIRANO, QUE ES UN PRODUCTO NUEVO EN EL QUE GP REPRESENTA A UN GRUPO PROTECTOR ADECUADO, PREFERIBLEMENTE BENCILO, SE HACE REACCIONAR CON 1-(4-METOXIFENIL)-2-PROPANAMINA PARA DAR UN N-[2-GP-OXI-5-[1-HIDROXI-2-[[2-(4-METOXIFENIL)-1-METILETIL]AMINO]ETIL]FENIL] FORMAMIDA, QUE TAMBIEN ES UN PRODUCTO NUEVO, Y QUE FINALMENTE SE DESPROTEGE MEDIANTE TRATAMIENTO CON FLUORURO DE HIDROGENO LIQUIDO PARA DAR (I).
ES8703715A 1987-12-23 1987-12-23 Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). Expired ES2005492A6 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8703715A ES2005492A6 (es) 1987-12-23 1987-12-23 Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8703715A ES2005492A6 (es) 1987-12-23 1987-12-23 Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Publications (1)

Publication Number Publication Date
ES2005492A6 true ES2005492A6 (es) 1989-03-01

Family

ID=8253876

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8703715A Expired ES2005492A6 (es) 1987-12-23 1987-12-23 Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Country Status (1)

Country Link
ES (1) ES2005492A6 (es)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3813B (en) 1990-09-26 1996-03-25 Astra Ab Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof
US6040344A (en) * 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
WO2005092840A1 (en) * 2004-03-23 2005-10-06 Pfizer Limited Formamide derivatives useful as adrenoceptor
US7342132B2 (en) 2001-11-09 2008-03-11 Sepracor Inc. Formoterol tartrate process and polymorph
EA010133B1 (ru) * 2004-03-23 2008-06-30 Пфайзер Инк. Производные формамида, пригодные в качестве адренорецептора
US7718822B2 (en) 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
CN113999134A (zh) * 2018-11-28 2022-02-01 广州健康元呼吸药物工程技术有限公司 一种福莫特罗、其可药用盐及其中间体的制备方法

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3813B (en) 1990-09-26 1996-03-25 Astra Ab Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof
US6040344A (en) * 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
US7732641B2 (en) 2001-11-09 2010-06-08 Sepracor Inc. Formoterol tartrate process and polymorph
US8110706B2 (en) 2001-11-09 2012-02-07 Sunovion Pharmaceuticals Inc. Formoterol tartrate process and polymorph
US7342132B2 (en) 2001-11-09 2008-03-11 Sepracor Inc. Formoterol tartrate process and polymorph
US7479572B2 (en) 2001-11-09 2009-01-20 Sepracor Inc. Formoterol tartrate process and polymorph
US7964753B2 (en) 2001-11-09 2011-06-21 Sunovion Pharmaceuticals Inc. Formoterol tartrate process and polymorph
EA010133B1 (ru) * 2004-03-23 2008-06-30 Пфайзер Инк. Производные формамида, пригодные в качестве адренорецептора
AU2005225632B2 (en) * 2004-03-23 2011-08-04 Pfizer Inc. Formamide derivatives useful as adrenoceptor
WO2005092840A1 (en) * 2004-03-23 2005-10-06 Pfizer Limited Formamide derivatives useful as adrenoceptor
US7718822B2 (en) 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
US8173829B2 (en) 2007-08-28 2012-05-08 Sunovion Pharmaceuticals Inc. Carbamate stereoisomer
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US8664441B2 (en) 2007-08-28 2014-03-04 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US9040588B2 (en) 2007-08-28 2015-05-26 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US9499476B2 (en) 2007-08-28 2016-11-22 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
CN113999134A (zh) * 2018-11-28 2022-02-01 广州健康元呼吸药物工程技术有限公司 一种福莫特罗、其可药用盐及其中间体的制备方法

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SA6 Expiration date (snapshot 920101)

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