ES2006361A6 - Un procedimiento para preparar derivados de insoindolinilo opticamente activos. - Google Patents

Un procedimiento para preparar derivados de insoindolinilo opticamente activos.

Info

Publication number
ES2006361A6
ES2006361A6 ES8800684A ES8800684A ES2006361A6 ES 2006361 A6 ES2006361 A6 ES 2006361A6 ES 8800684 A ES8800684 A ES 8800684A ES 8800684 A ES8800684 A ES 8800684A ES 2006361 A6 ES2006361 A6 ES 2006361A6
Authority
ES
Spain
Prior art keywords
optically active
compound
alkyl
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800684A
Other languages
English (en)
Inventor
Giovanni Carniel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of ES2006361A6 publication Critical patent/ES2006361A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ISOINDOLINILO OPTICAMENTE ACTIVOS DE FORMULA (I):O UNA SAL DEL MISMO FISIOLOGICAMENTE ACEPTABLE; QUE CONSISTE EN: A) RESOLVER UN COMPUESTO RACEMICO DE FORMULA (II)EN SUS ISOMEROS OPTICOS, PARA DAR UN COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (II) EN FORMA LIBRE O DE SAL; B) HACER REACCIONAR EL COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (II), OBTENIDO EN LA ETAPA ANTERIOR, EN FORMA LIBRE O DE SAL, CON ANHIDRIDO O-FTALICO PARA DAR UN FTALIMIDO COMPUESTO OPTICAMENTE ACTIVO, DE FORMULA (III)C)REDUCIR EL COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (III); Y, SI SE QUIERE, ESTERIFICAR UN COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (I) PARA DAR EL CORRESPONDIENTE COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (I) O SALIFICARLO CON UNA BASE FISIOLOGICAMENTE ACEPTABLE PARA DAR UNA SAL DEL MISMO FISIOLOGICAMENTE ACEPTABLE.LOS COMPUESTOS DE FORMULA (I), PRESENTAN POTENTE ACTIVIDAD INHIBIDORA DE LA AGREGACION DE PLAQUETAS.
ES8800684A 1987-03-10 1988-03-08 Un procedimiento para preparar derivados de insoindolinilo opticamente activos. Expired ES2006361A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878705601A GB8705601D0 (en) 1987-03-10 1987-03-10 Oxo-isoindolinyl derivatives

Publications (1)

Publication Number Publication Date
ES2006361A6 true ES2006361A6 (es) 1989-04-16

Family

ID=10613660

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800684A Expired ES2006361A6 (es) 1987-03-10 1988-03-08 Un procedimiento para preparar derivados de insoindolinilo opticamente activos.

Country Status (29)

Country Link
JP (1) JPH0759555B2 (es)
KR (1) KR880011096A (es)
CN (1) CN1017527B (es)
AT (1) AT392068B (es)
AU (1) AU605253B2 (es)
BE (1) BE1003280A3 (es)
CH (1) CH675419A5 (es)
DE (1) DE3807595A1 (es)
DK (1) DK168568B1 (es)
ES (1) ES2006361A6 (es)
FI (1) FI93725C (es)
FR (1) FR2612185B1 (es)
GB (2) GB8705601D0 (es)
GR (1) GR1000515B (es)
HU (1) HU201011B (es)
IE (1) IE60565B1 (es)
IL (1) IL85651A (es)
IT (1) IT1227787B (es)
MY (1) MY103898A (es)
NL (1) NL8800575A (es)
NO (1) NO174666C (es)
NZ (1) NZ223805A (es)
PH (1) PH26254A (es)
PT (1) PT86933B (es)
SE (1) SE500710C2 (es)
SU (1) SU1731046A3 (es)
UA (1) UA12840A1 (es)
YU (1) YU46565B (es)
ZA (1) ZA881686B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
CN100400633C (zh) * 2006-03-30 2008-07-09 中国日用化学工业研究院 一种手洗餐具洗涤剂及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2154525A1 (de) * 1970-11-05 1972-06-15 Carlo Erba S.P.A., Mailand (Italien) Isoindolinderivate und Verfahren zu ihrer Herstellung
GB1344663A (en) * 1970-11-10 1974-01-23 Erba Carlo Spa Isoindoline compounds
US4010274A (en) * 1973-07-27 1977-03-01 Carlo Erba Isoindoline derivatives having platelet anti-aggregating activity
JPS516959A (en) * 1974-07-04 1976-01-20 Wakamoto Pharma Co Ltd Isoindorinjudotaino seizohoho
US4400520A (en) * 1980-09-10 1983-08-23 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindoline derivatives
IT1201408B (it) * 1985-03-22 1989-02-02 Montedison Spa Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
JPH07120969B2 (ja) * 1989-03-30 1995-12-20 クラリオン株式会社 スペクトラム拡散変調装置

Also Published As

Publication number Publication date
FI881075A0 (fi) 1988-03-09
KR880011096A (ko) 1988-10-26
IT8819683A0 (it) 1988-03-08
AU605253B2 (en) 1991-01-10
SE500710C2 (sv) 1994-08-15
JPH0759555B2 (ja) 1995-06-28
NO881055L (no) 1988-09-12
DE3807595A1 (de) 1988-09-22
NL8800575A (nl) 1988-10-03
FI93725B (fi) 1995-02-15
PT86933A (pt) 1988-04-01
SE8800846D0 (sv) 1988-03-09
FR2612185B1 (fr) 1992-08-28
MY103898A (en) 1993-10-30
JPS63238058A (ja) 1988-10-04
SU1731046A3 (ru) 1992-04-30
UA12840A1 (uk) 1997-02-28
IE60565B1 (en) 1994-07-27
YU46565B (sh) 1993-11-16
FR2612185A1 (fr) 1988-09-16
GB8805631D0 (en) 1988-04-07
SE8800846L (sv) 1988-09-11
PT86933B (pt) 1992-05-29
AU1267988A (en) 1988-09-08
DK128988A (da) 1988-09-11
YU46788A (en) 1990-04-30
BE1003280A3 (fr) 1992-02-18
IT1227787B (it) 1991-05-07
GB2204579A (en) 1988-11-16
NO174666B (no) 1994-03-07
HU201011B (en) 1990-09-28
IE880648L (en) 1988-09-10
FI93725C (fi) 1995-05-26
GR1000515B (el) 1992-07-30
NO174666C (no) 1994-06-15
NZ223805A (en) 1990-11-27
IL85651A0 (en) 1988-08-31
IL85651A (en) 1991-07-18
DK128988D0 (da) 1988-03-09
GR880100137A (en) 1989-01-31
GB2204579B (en) 1991-01-30
GB8705601D0 (en) 1987-04-15
CH675419A5 (es) 1990-09-28
HUT47247A (en) 1989-02-28
CN88101200A (zh) 1988-10-26
DK168568B1 (da) 1994-04-25
ATA58988A (de) 1990-07-15
AT392068B (de) 1991-01-25
NO881055D0 (no) 1988-03-09
PH26254A (en) 1992-04-01
CN1017527B (zh) 1992-07-22
ZA881686B (en) 1989-11-29
FI881075A7 (fi) 1988-09-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108