ES2006891A6 - Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina. - Google Patents

Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.

Info

Publication number
ES2006891A6
ES2006891A6 ES8801088A ES8801088A ES2006891A6 ES 2006891 A6 ES2006891 A6 ES 2006891A6 ES 8801088 A ES8801088 A ES 8801088A ES 8801088 A ES8801088 A ES 8801088A ES 2006891 A6 ES2006891 A6 ES 2006891A6
Authority
ES
Spain
Prior art keywords
heparin
soln
fractions
low
ultrafiltering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801088A
Other languages
English (en)
Inventor
Pahi Francisco J Vila
Alberto David Nusimovich
Torne Pedro Gomis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA filed Critical Bioiberica SA
Priority to ES8801088A priority Critical patent/ES2006891A6/es
Priority to EP89106213A priority patent/EP0337327A1/en
Priority to US07/335,942 priority patent/US5084564A/en
Priority to JP1091692A priority patent/JPH02206601A/ja
Publication of ES2006891A6 publication Critical patent/ES2006891A6/es
Expired legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE FRACCIONES DE OLIGOSACARIDOS POR DEPOLIMERIZACION QUIMICA CONTROLADA DE HEPARINA. CONSISTE EN LA PREPARACION DE FRACCIONES DE OLIGOSACARIDOS CARACTERIZADA PORQUE SE DEPOLIMERIZA LA HEPARINA EN SOLUCION ACUOSA PASANDOLA LUEGO A TRAVES DE MEMBRANAS SELECTIVAS DE ULTRAFILTRACION PREVIAMENTE A TAL DEPOLIMERIZACION CON EL OBJETO DE EXCLUIR LAS FRACCIONES DE PESO MOLECULAR INFERIORES A 3000 DALTONS. POSTERIORMENTE SE PROCEDE A UN FRACCIONAMIENTO POR PARTICION DE FASES LIQUIDAS CON EL OBJETO DE EXCLUIR DE LA POLIMERIZACION LAS FRACCIONES DE BAJA ANIONIZIDAD, EFECTUANDOSE TODAS LAS ETAPAS EN FASE LIQUIDA SIN AISLAMIENTO DE PRODUCTOS INTERMEDIOS Y PUDIENDOSE EFECTUAR LA DEPOLIMERIZACION QUIMICA CONTROLADA EN MAS DE UN CICLO. APLICABLE A PRODUCTOS FARMACEUTICOS DE ACTIVIDAD ANTITROMBONICA CON DISMUNICION DEL RIESGO HEMORRAGICO.
ES8801088A 1988-04-09 1988-04-09 Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina. Expired ES2006891A6 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES8801088A ES2006891A6 (es) 1988-04-09 1988-04-09 Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.
EP89106213A EP0337327A1 (en) 1988-04-09 1989-04-07 Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
US07/335,942 US5084564A (en) 1988-04-09 1989-04-10 Production of oligosaccharide fractions having antithrombotic properties by controlled chemical depolymerization of heparin
JP1091692A JPH02206601A (ja) 1988-04-09 1989-04-10 抗トロンビン作用を有するオリゴサッカライドフラクションの製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8801088A ES2006891A6 (es) 1988-04-09 1988-04-09 Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.

Publications (1)

Publication Number Publication Date
ES2006891A6 true ES2006891A6 (es) 1989-05-16

Family

ID=8255754

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801088A Expired ES2006891A6 (es) 1988-04-09 1988-04-09 Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.

Country Status (1)

Country Link
ES (1) ES2006891A6 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036922A1 (es) * 1990-06-26 1993-06-01 Rhone Poulenc Rorer Sa Procedimiento de obtencion de mezclas de polisacaridos de bajos pesos moleculares.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036922A1 (es) * 1990-06-26 1993-06-01 Rhone Poulenc Rorer Sa Procedimiento de obtencion de mezclas de polisacaridos de bajos pesos moleculares.

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010410