ES2008067T3 - Analogos de prostaciclina (pgi2). - Google Patents
Analogos de prostaciclina (pgi2).Info
- Publication number
- ES2008067T3 ES2008067T3 ES87104669T ES87104669T ES2008067T3 ES 2008067 T3 ES2008067 T3 ES 2008067T3 ES 87104669 T ES87104669 T ES 87104669T ES 87104669 T ES87104669 T ES 87104669T ES 2008067 T3 ES2008067 T3 ES 2008067T3
- Authority
- ES
- Spain
- Prior art keywords
- pgi2
- hydrogen
- straight
- prostacicline
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000862089 Clarkia lewisii Glucose-6-phosphate isomerase, cytosolic 1A Proteins 0.000 title 1
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- -1 arythio Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
- 229960001123 epoprostenol Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003174 prostaglandin I2 derivatives Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paper (AREA)
- Vending Machines For Individual Products (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
ANALOGOS DE PROSTACICLINA (PG12), REPRESENTADOS POR LA FORMULA GENERAL (I), EN LA QUE R1 ES HIDROGENO O ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, ARALQUINILO INFERIOR, ALQUILOXI INFERIOR, ARILTIO O CIANO; R3 Y R4 SON CADA UNO DE ELLOS HIDROGENO O UN GRUPO PROTECTOR DE HIDROXI; R5 ES ALQUILO DE CADENA LINEAL O RAMIFICADA, QUE PUEDE ESTAR SUSTITUIDO CON UN HETEROCICLO, CON UN ALQUINILO DE CADENA LINEAL O RAMIFICADA, O CON UN CICLOALQUILO; LA LINEA ONDULADA INDICA CONFIGURACUON R- O S-; O SU MEZCLA; O UNA DE SUS SLAES, QUE SE EMPLEAN COMO FARMACOS ANTITROMBOTICOS Y ANTIULCEROSOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7493286 | 1986-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2008067A4 ES2008067A4 (es) | 1989-07-16 |
| ES2008067T3 true ES2008067T3 (es) | 1994-11-16 |
Family
ID=13561619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87104669T Expired - Lifetime ES2008067T3 (es) | 1986-03-31 | 1987-03-30 | Analogos de prostaciclina (pgi2). |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4820836A (es) |
| EP (1) | EP0240890B1 (es) |
| JP (1) | JPH07121907B2 (es) |
| AT (1) | ATE97404T1 (es) |
| CA (1) | CA1284642C (es) |
| DE (2) | DE240890T1 (es) |
| ES (1) | ES2008067T3 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227157B1 (en) * | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective oxidation |
| US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7790362B2 (en) * | 2003-07-08 | 2010-09-07 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| US20080299587A1 (en) * | 2007-05-03 | 2008-12-04 | Dennis Durbin | Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists |
| CA2734500A1 (en) | 2008-08-27 | 2010-03-11 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3006865A1 (de) | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Hetero-imino-prostacycline |
| US4496742A (en) * | 1981-10-13 | 1985-01-29 | The Upjohn Company | Analogs of 5,6-dihydro PGI2 |
| US4588823A (en) * | 1982-02-16 | 1986-05-13 | The Upjohn Company | 9-substituted carbacyclin analogs |
| US4487960A (en) * | 1982-04-19 | 1984-12-11 | The Upjohn Company | 9-Substituted carbacyclin analogs |
-
1987
- 1987-03-11 CA CA000531708A patent/CA1284642C/en not_active Expired - Fee Related
- 1987-03-13 US US07/025,807 patent/US4820836A/en not_active Expired - Fee Related
- 1987-03-20 JP JP62066817A patent/JPH07121907B2/ja not_active Expired - Fee Related
- 1987-03-30 DE DE198787104669T patent/DE240890T1/de active Pending
- 1987-03-30 AT AT87104669T patent/ATE97404T1/de not_active IP Right Cessation
- 1987-03-30 EP EP87104669A patent/EP0240890B1/en not_active Expired - Lifetime
- 1987-03-30 ES ES87104669T patent/ES2008067T3/es not_active Expired - Lifetime
- 1987-03-30 DE DE87104669T patent/DE3788149T2/de not_active Expired - Fee Related
-
1988
- 1988-08-01 US US07/226,844 patent/US4855449A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0240890B1 (en) | 1993-11-18 |
| ATE97404T1 (de) | 1993-12-15 |
| US4855449A (en) | 1989-08-08 |
| DE3788149D1 (de) | 1993-12-23 |
| JPS6366168A (ja) | 1988-03-24 |
| US4820836A (en) | 1989-04-11 |
| EP0240890A3 (en) | 1989-05-10 |
| EP0240890A2 (en) | 1987-10-14 |
| ES2008067A4 (es) | 1989-07-16 |
| JPH07121907B2 (ja) | 1995-12-25 |
| CA1284642C (en) | 1991-06-04 |
| DE3788149T2 (de) | 1994-04-07 |
| DE240890T1 (de) | 1988-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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