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Yamanouchi Pharmaceutical Co Ltd
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Yamanouchi Pharmaceutical Co Ltd
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Application filed by Yamanouchi Pharmaceutical Co LtdfiledCriticalYamanouchi Pharmaceutical Co Ltd
Priority to ES8901500ApriorityCriticalpatent/ES2013184A6/en
Publication of ES2013184A6publicationCriticalpatent/ES2013184A6/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
A procedure for producing an improved tissue-type plasminogen activator (t-PA). It involves: (a) obtaining the gene coding for the molecule of improved t-PA by hybridization of the t-PA gene with an oligonucleotide probe (b) inserting the gene obtained into an expression vector (c) transfecting the expression vector into a host cell (d) recovering the improved t-PA produced in the previous stage. Application in the treatment of diseases of a thrombotic nature.
ES8901500A1989-04-281989-04-28A procedure for producing an improved tissue-type plasminogen activator (t-PA)
Expired - Fee RelatedES2013184A6
(en)
Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and DNA and transformed cell intermediates therefor.
Nucleic acid sequence encoding an amino acid variant of human plasminogen, expression vector and host cell comprising the same, as well as a method for producing an amino acid variant of plasminogen and a method for producing a binary complex between a fibrinolytic ...
"MOLECULA POLINUCLEOTIDICA THAT INCLUDES A NUCLEOTIDE SEQUENCE OF AVERMITILE STREPTOMICES THAT DIRECTS THE RELATIONSHIP OF AVERMECTINES B2: B1, RECOMBINING VECTOR, CELLULA HUESPED, PROCEDURE FOR OBTAINING A CELL OF S. AVERITILISD DEVICE.