ES2019166A6 - PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS. - Google Patents

PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS.

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Publication number
ES2019166A6
ES2019166A6 ES8903384A ES8903384A ES2019166A6 ES 2019166 A6 ES2019166 A6 ES 2019166A6 ES 8903384 A ES8903384 A ES 8903384A ES 8903384 A ES8903384 A ES 8903384A ES 2019166 A6 ES2019166 A6 ES 2019166A6
Authority
ES
Spain
Prior art keywords
procedure
substituted
methyl esters
amino acid
aminoacidosn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903384A
Other languages
Spanish (es)
Inventor
Rubio Felipa Maria Bautista
Perez Juan Manuel Campelo
Coleto Angel Garcia
Fresneda Enrique Garcia
Martinez Diego Luna
Rubio Jose Maria Marinas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Córdoba
Original Assignee
University of Córdoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Córdoba filed Critical University of Córdoba
Priority to ES8903384A priority Critical patent/ES2019166A6/en
Publication of ES2019166A6 publication Critical patent/ES2019166A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

ESTA INVENCION SE REFIERE A UN PROCEDIMIENTO QUE PERMITE LA SEPARACION DE UNA MEZCLA RACEMICA DE ESTERES METILICOS N-SUSTITUIDOS MEDIANTE LA HIDROLISIS ENANTIOSELECTIVA DEL GRUPO ESTER EN EL L-AMINOACIDO POR LA ACCION DE LA ENZIMA <LIPASA PANCREATICA DEL CERDO> (TRIACILGLICEROL ACILHIDROLASA EC 3.1.1.3), DE ACUERDO AL ESQUEMA DE REACCION DONDE R Y R'' PUEDEN, EN PRINCIPIO, SER CUALQUIER SUSTITUYENTE ALQUILICO O AROMATICO SIN SUSTITUIR O CON UNO O MAS SUSTITUYENTES: HIDROGENO, HALOGENO, ALQUILO, ALQUENILO, ALQUINILO (CADENAS ALQUILENICAS, ALQUENILENICAS O ALQUINILENICAS), NITRO, AMINO, CIANO, ALCOXI, N-BUTOXI, I-BUTOXI, FENOXI, BENCILOXI; QUE PERMITE LA SEPARACION SUCESIVA DE AMBOS ENANTIOMEROS, POR EXTRACCION CON UN DISOLVENTE ORGANICO ADECUADO, POR EJEMPLO, CLOROFORMO. PRIMERO SE EXTRAE EL ESTER METILICO DEL D-AMINOACIDO N-SUSTITUIDO Y A CONTINUACION, PREVIA ACIDULACION DEL MEDIO, EL L-AMINOACIDO N-SUSTITUIDO. FORMULA.THIS INVENTION REFERS TO A PROCEDURE THAT ALLOWS THE SEPARATION OF A RACEMIC MIXTURE OF N-SUBSTITUTED METHYL ESTERS THROUGH THE ENANTIOSELECTIVE HYDROLYSIS IN THE L-AMINO ACID-LIACIDE-ACID-LANDSIDE OF THE ENZYME - LIPASA PANCREA .1.3) According to the reaction scheme wherein r '' can, in principle, be any substituent alkyl or aromatic unsubstituted or with one or more substituents: hydrogen, halogen, alkyl, alkenyl, alkynyl (CHAINS ALQUILENICAS, ALQUENILENICAS O ALKINYLENICAS), NITRO, AMINO, CIANO, ALCOXI, N-BUTOXI, I-BUTOXI, FENOXI, BENCILOXI; THAT ALLOWS THE SUCCESSIVE SEPARATION OF BOTH ENANTIOMERS, BY EXTRACTION WITH A SUITABLE ORGANIC SOLVENT, FOR EXAMPLE, CHLOROFORM. FIRST THE METHYL ESTER OF N-SUBSTITUTED D-AMINO ACID IS EXTRACTED AND THEN, PREVIOUS ACIDULATION OF THE MEDIUM, THE N-SUBSTITUTED L-AMINO ACID. FORMULA.

ES8903384A 1989-09-25 1989-09-25 PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS. Expired - Lifetime ES2019166A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8903384A ES2019166A6 (en) 1989-09-25 1989-09-25 PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8903384A ES2019166A6 (en) 1989-09-25 1989-09-25 PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS.

Publications (1)

Publication Number Publication Date
ES2019166A6 true ES2019166A6 (en) 1991-06-01

Family

ID=8264221

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903384A Expired - Lifetime ES2019166A6 (en) 1989-09-25 1989-09-25 PROCEDURE FOR THE ENZYMATIC RESOLUTION OF OPTICALLY ACTIVE ISOMERS OF AMINOACIDOSN-SUBSTITUTED METHYL ESTERS.

Country Status (1)

Country Link
ES (1) ES2019166A6 (en)

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-09-25

FD2A Announcement of lapse in spain

Effective date: 20141120