ES2019166A6 - Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos. - Google Patents
Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos.Info
- Publication number
- ES2019166A6 ES2019166A6 ES8903384A ES8903384A ES2019166A6 ES 2019166 A6 ES2019166 A6 ES 2019166A6 ES 8903384 A ES8903384 A ES 8903384A ES 8903384 A ES8903384 A ES 8903384A ES 2019166 A6 ES2019166 A6 ES 2019166A6
- Authority
- ES
- Spain
- Prior art keywords
- methyl esters
- substituted
- amino acid
- amino acids
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 N-substituted amino Chemical class 0.000 title abstract 3
- 150000004702 methyl esters Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 150000008575 L-amino acids Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102100031375 Endothelial lipase Human genes 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 102000019280 Pancreatic lipases Human genes 0.000 abstract 1
- 108050006759 Pancreatic lipases Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229940116369 pancreatic lipase Drugs 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
ESTA INVENCION SE REFIERE A UN PROCEDIMIENTO QUE PERMITE LA SEPARACION DE UNA MEZCLA RACEMICA DE ESTERES METILICOS N-SUSTITUIDOS MEDIANTE LA HIDROLISIS ENANTIOSELECTIVA DEL GRUPO ESTER EN EL L-AMINOACIDO POR LA ACCION DE LA ENZIMA <LIPASA PANCREATICA DEL CERDO> (TRIACILGLICEROL ACILHIDROLASA EC 3.1.1.3), DE ACUERDO AL ESQUEMA DE REACCION DONDE R Y R'' PUEDEN, EN PRINCIPIO, SER CUALQUIER SUSTITUYENTE ALQUILICO O AROMATICO SIN SUSTITUIR O CON UNO O MAS SUSTITUYENTES: HIDROGENO, HALOGENO, ALQUILO, ALQUENILO, ALQUINILO (CADENAS ALQUILENICAS, ALQUENILENICAS O ALQUINILENICAS), NITRO, AMINO, CIANO, ALCOXI, N-BUTOXI, I-BUTOXI, FENOXI, BENCILOXI; QUE PERMITE LA SEPARACION SUCESIVA DE AMBOS ENANTIOMEROS, POR EXTRACCION CON UN DISOLVENTE ORGANICO ADECUADO, POR EJEMPLO, CLOROFORMO. PRIMERO SE EXTRAE EL ESTER METILICO DEL D-AMINOACIDO N-SUSTITUIDO Y A CONTINUACION, PREVIA ACIDULACION DEL MEDIO, EL L-AMINOACIDO N-SUSTITUIDO. FORMULA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8903384A ES2019166A6 (es) | 1989-09-25 | 1989-09-25 | Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8903384A ES2019166A6 (es) | 1989-09-25 | 1989-09-25 | Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2019166A6 true ES2019166A6 (es) | 1991-06-01 |
Family
ID=8264221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8903384A Expired - Lifetime ES2019166A6 (es) | 1989-09-25 | 1989-09-25 | Procedimiento para la resolucion enzimatica de los isomeros opticamente activos de los esteres metilicos de aminoacidosn-sustituidos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2019166A6 (es) |
-
1989
- 1989-09-25 ES ES8903384A patent/ES2019166A6/es not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-09-25 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20141120 |