ES2019199A6 - Production of indane derivative and synthetic intermediate therefor - Google Patents
Production of indane derivative and synthetic intermediate thereforInfo
- Publication number
- ES2019199A6 ES2019199A6 ES8904304A ES8904304A ES2019199A6 ES 2019199 A6 ES2019199 A6 ES 2019199A6 ES 8904304 A ES8904304 A ES 8904304A ES 8904304 A ES8904304 A ES 8904304A ES 2019199 A6 ES2019199 A6 ES 2019199A6
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- condensing
- group
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain a compound having thromboxane A2 antagonistic action and useful as a platelet aggregation suppressing agent by reducing an indane derivative and condensing with a sulfonic acid. CONSTITUTION:The objective compound of formula II can be produced by reducing a compound of formula I (R<1> is -SO3R or H R is phenyl, naphthyl or sulfur-containing heterocyclic group R<2> is H or lower alkyl R<3> is lower alkoxycarbonyl-lower alkyl, etc. Y is phenylmercaptomethylene, lower alkylmercaptomethylene, carbonyl, etc.) or its salt to convert the group Y into methylene group and, when R<1> is H, condensing the reduction product with a sulfonic acid compound of formula RSO3H or its reactive derivative. The starting compound of formula I is novel compound which can be produced by condensing a compound of formula III (R<11> is -SO2R or amino-protecting group) with a compound of formula IV (Y<1> is phenylmercaptomethylene, etc. X is halogen).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63323884A JPH02169563A (en) | 1988-12-22 | 1988-12-22 | Production of indane derivative and synthetic intermediate therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2019199A6 true ES2019199A6 (en) | 1991-06-01 |
Family
ID=18159677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8904304A Expired - Lifetime ES2019199A6 (en) | 1988-12-22 | 1989-12-20 | Production of indane derivative and synthetic intermediate therefor |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPH02169563A (en) |
| CN (1) | CN1025563C (en) |
| ES (1) | ES2019199A6 (en) |
| FI (1) | FI896116A7 (en) |
| GR (1) | GR1000458B (en) |
| HU (1) | HU206196B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012500189A (en) * | 2008-08-15 | 2012-01-05 | エフ．ホフマン−ラ ロシュ アーゲー | Biarylaminotetralin |
| CN103539709B (en) * | 2013-03-22 | 2015-11-25 | 湖北生物医药产业技术研究院有限公司 | N-(-1-hydrogen-indenes-1-base) sulfamide compound and its production and use |
| CN115872907B (en) * | 2021-09-29 | 2024-01-30 | 中国石油化工股份有限公司 | Sulfonate thickened oil viscosity reducer and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623944A1 (en) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | NEW BENZOLSULFONAMIDO INDANYL COMPOUNDS, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| IL88314A (en) * | 1987-11-18 | 1994-05-30 | Tanabe Seiyaku Co | Sulphonylamino indane derivatives, their preparation and pharmaceutical compositions containing them |
-
1988
- 1988-12-22 JP JP63323884A patent/JPH02169563A/en active Granted
-
1989
- 1989-11-30 CN CN89109011A patent/CN1025563C/en not_active Expired - Fee Related
- 1989-12-13 GR GR890100822A patent/GR1000458B/en unknown
- 1989-12-20 FI FI896116A patent/FI896116A7/en not_active Application Discontinuation
- 1989-12-20 ES ES8904304A patent/ES2019199A6/en not_active Expired - Lifetime
- 1989-12-21 HU HU896730A patent/HU206196B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02169563A (en) | 1990-06-29 |
| GR1000458B (en) | 1992-07-30 |
| HUT52753A (en) | 1990-08-28 |
| FI896116A7 (en) | 1990-06-23 |
| JPH0524147B2 (en) | 1993-04-06 |
| HU206196B (en) | 1992-09-28 |
| CN1043703A (en) | 1990-07-11 |
| HU896730D0 (en) | 1990-02-28 |
| GR890100822A (en) | 1991-03-15 |
| CN1025563C (en) | 1994-08-03 |
| FI896116A0 (en) | 1989-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-12-20 |