JPS5653685A - Production of cephalosporin derivative - Google Patents
Production of cephalosporin derivativeInfo
- Publication number
- JPS5653685A JPS5653685A JP12927479A JP12927479A JPS5653685A JP S5653685 A JPS5653685 A JP S5653685A JP 12927479 A JP12927479 A JP 12927479A JP 12927479 A JP12927479 A JP 12927479A JP S5653685 A JPS5653685 A JP S5653685A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reaction
- cephalosporin derivative
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YHMYGUUIMTVXNW-UHFFFAOYSA-N 1,3-dihydrobenzimidazole-2-thione Chemical compound C1=CC=C2NC(S)=NC2=C1 YHMYGUUIMTVXNW-UHFFFAOYSA-N 0.000 abstract 1
- JUNAPQMUUHSYOV-UHFFFAOYSA-N 2-(2h-tetrazol-5-yl)acetic acid Chemical compound OC(=O)CC=1N=NNN=1 JUNAPQMUUHSYOV-UHFFFAOYSA-N 0.000 abstract 1
- -1 7-amino-cephem compound Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: The reaction of a readily available 7-amino-cephem compound with 1H- tetrazolacetic acid or its reactive derivative gives a cephalosporin derivative useful as a synthetic intermediate of antibacterial.
CONSTITUTION: A compound of formula I or its salt is made to react with another compound of formula II or its reactive derivative in the carboxyl to give a cephalosporin derivative of formula III or its salt. The reaction is carried out in a solvent such as acetone, when necessary, in the presence of a condensing agent in a pH range from 6.0 to 7.5. The resultant compound of formula III is made to react with a compound of formula IV (R is H, methyl) to produce the compound of formula V useful as an antibacterial in high efficiency and safety. The compound of formula I is readily obtained by the reaction of 7-aminocephalospranic acid with 2-mercaptobenzimidazole.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12927479A JPS5930714B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12927479A JPS5930714B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5653685A true JPS5653685A (en) | 1981-05-13 |
| JPS5930714B2 JPS5930714B2 (en) | 1984-07-28 |
Family
ID=15005529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12927479A Expired JPS5930714B2 (en) | 1979-10-06 | 1979-10-06 | Method for producing cephalosporin derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5930714B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60158909U (en) * | 1984-03-31 | 1985-10-22 | いすゞ自動車株式会社 | Window frame molding structure |
-
1979
- 1979-10-06 JP JP12927479A patent/JPS5930714B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5930714B2 (en) | 1984-07-28 |
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