ES2019551A6 - Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico. - Google Patents

Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico.

Info

Publication number
ES2019551A6
ES2019551A6 ES9001050A ES9001050A ES2019551A6 ES 2019551 A6 ES2019551 A6 ES 2019551A6 ES 9001050 A ES9001050 A ES 9001050A ES 9001050 A ES9001050 A ES 9001050A ES 2019551 A6 ES2019551 A6 ES 2019551A6
Authority
ES
Spain
Prior art keywords
derivatives
fluoro
dihydro
oxo
quinolinecarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9001050A
Other languages
English (en)
Inventor
Buron Enrique Dominguez
Arcilagos Anna Bosch
Moya Jose Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ercros SA
Original Assignee
Ercros SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ercros SA filed Critical Ercros SA
Priority to ES9001050A priority Critical patent/ES2019551A6/es
Priority to PCT/ES1991/000021 priority patent/WO1991015477A1/es
Priority to PT9732091A priority patent/PT97320B/pt
Priority to MA22389A priority patent/MA22120A1/fr
Publication of ES2019551A6 publication Critical patent/ES2019551A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO 6-FLUOR-1, 4-DIHIDRO-4-OXO-7-PIPERACINIL-3-QUINOLINCARBOXILICO DE FORMULA (I) DONDE RSI1 ES H, ALQUILO O HIDROXIALQUILO LINEAL O RAMIFICADO DE 1 A 4 ATOMOS DE C Y RSI2 ES ALQUILO LINEAL O CICLICO DE 1 A 4 ATOMOS DE C. EL PROCEDIMIENTO COMPRENDE LA REACCION DE UN COMPUESTO (VI) DONDE RSI3 ES ALQUILO LINEAL O RAMIFICADO DE 1 A 5 ATOMOS DE C Y RSI1 PUEDE SER ADEMAS ACILO O ALCOXICARBONILO, CON HNA Y POSTERIOR HIDROLISIS ACIDA DEL ESTER CICLADO OBTENIDO. ALGUNO DE LOS COMPUESTOS (VI) DE PARTIDA SON NUEVOS, CONCRETAMENTE EL 3-(CICLOPROPILAMINO)-2-[CLORO-5-FLUOR-4-(4-ETOXICARBONIL-1-PIPERACINIL)BENZOIL] ACRILATO DE ETILO. DENTRO DE LOS COMPUESTOS (I) CAPACES DE SER OBTENIDOS SEGUN ESTE PROCEDIMIENTO SE ENCUENTRAN LA CIPROFLOXACINA, NORFLOXACINA Y ENROFLOXACINA QUE TIENEN ACTIVIDAD ANTIBACTERIANA POR LO QUE SON ADECUADOS EN TERAPIA.
ES9001050A 1990-04-11 1990-04-11 Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico. Expired - Lifetime ES2019551A6 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9001050A ES2019551A6 (es) 1990-04-11 1990-04-11 Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico.
PCT/ES1991/000021 WO1991015477A1 (es) 1990-04-11 1991-04-10 Procedimiento para la obtencion de derivados del acido 6-fluor-1,4-dihidro-4-oxo-7-piperacinil-3-quinolincarboxilico y derivados de acrilato utilizados en dicho procedimiento
PT9732091A PT97320B (pt) 1990-04-11 1991-04-10 Processo para a preparacao de derivados do acido 6-fluor-1,4-dihidro-4-oxo-7-piperazinil-quinolinocarboxilico
MA22389A MA22120A1 (fr) 1990-04-11 1991-04-10 Procede d'obtention de derives de l'acide 6-fluoro-i,4-dehydro-4-oxo-7-piperazinyl-3-quinoleine-carboxylique et derives d'acrylate utilises dans ce procede

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9001050A ES2019551A6 (es) 1990-04-11 1990-04-11 Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico.

Publications (1)

Publication Number Publication Date
ES2019551A6 true ES2019551A6 (es) 1991-06-16

Family

ID=8266852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9001050A Expired - Lifetime ES2019551A6 (es) 1990-04-11 1990-04-11 Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico.

Country Status (4)

Country Link
ES (1) ES2019551A6 (es)
MA (1) MA22120A1 (es)
PT (1) PT97320B (es)
WO (1) WO1991015477A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109574924A (zh) * 2019-01-16 2019-04-05 浙江国邦药业有限公司 一种恩诺沙星残液回收利用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds

Also Published As

Publication number Publication date
WO1991015477A1 (es) 1991-10-17
PT97320A (pt) 1992-01-31
PT97320B (pt) 1998-08-31
MA22120A1 (fr) 1991-12-31

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Legal Events

Date Code Title Description
RD1A Patent seized

Effective date: 19930915

PC1A Transfer granted
RD1A Patent seized

Effective date: 20010926

FD2A Announcement of lapse in spain

Effective date: 20180802