ES2019728A6 - Procedimiento de preparacion de una vacuna de inmunoterapia para tumores de melanoma. - Google Patents
Procedimiento de preparacion de una vacuna de inmunoterapia para tumores de melanoma.Info
- Publication number
- ES2019728A6 ES2019728A6 ES8903606A ES8903606A ES2019728A6 ES 2019728 A6 ES2019728 A6 ES 2019728A6 ES 8903606 A ES8903606 A ES 8903606A ES 8903606 A ES8903606 A ES 8903606A ES 2019728 A6 ES2019728 A6 ES 2019728A6
- Authority
- ES
- Spain
- Prior art keywords
- cell
- vaccine
- produced
- antigens
- msm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000001441 melanoma Diseases 0.000 title abstract 4
- 229940032219 immunotherapy vaccine Drugs 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000013592 cell lysate Substances 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 229960001438 immunostimulant agent Drugs 0.000 abstract 2
- 239000003022 immunostimulating agent Substances 0.000 abstract 2
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 108010039939 Cell Wall Skeleton Proteins 0.000 abstract 1
- 230000000735 allogeneic effect Effects 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 210000004520 cell wall skeleton Anatomy 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE UNA NUEVA VACUNA DE INMUNOTERAPIA PARA TUMORES DE MELANOMA, QUE CONSISTE EN QUE CELULAS OBTENIDAS RECIENTEMENTE DE BIOPSIAS DE FRAGMENTOS TUMORALES DE CELULAS DE MELANOMA, O DE FUENTES DE CELULAS CONGELADAS A 70GC, SE FRACCIONAN MECANICAMENTE MEDIANTE UN HOMOGENEIZADOR DE TEJIDOS DE ALTA VELOCIDAD; LOS LISATOS DE CELULAS ASI FORMADOS SE MEZCLAN EFICAZMENTE CON UN COADYUVANTE CONSTITUIDO POR UNA ENDOTOXINA DESTOXIFICADA REFINADA, Y CON UN INMUNOESTIMULANTE BIOLOGICO ELEGIDO DEL GRUPO CONSTITUIDO POR ESQUELETO DE PARED CELULAR MICROBACTERIANO, DIMICOLATO DE TETRAHALOSA, EXTRACTO SOLUBLE DE PIRIDINA DE UN MICROORGANISMO, Y SUS MEZCLAS. EL PROCEDIMIENTO SE USA PARA PREPARAR VACUNAS HALOGENICAS ESTANDARIZADAS, APROPIADAS PARA INMUNOTERAPIA DE MELANOMAS AUTOLOGOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24854388A | 1988-09-23 | 1988-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2019728A6 true ES2019728A6 (es) | 1991-07-01 |
Family
ID=22939592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8903606A Expired - Lifetime ES2019728A6 (es) | 1988-09-23 | 1989-09-22 | Procedimiento de preparacion de una vacuna de inmunoterapia para tumores de melanoma. |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPH04501663A (es) |
| AU (1) | AU4338189A (es) |
| ES (1) | ES2019728A6 (es) |
| WO (1) | WO1990003183A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9620350D0 (en) | 1996-09-30 | 1996-11-13 | Maudsley David J | Cancer vaccine |
| CN100425287C (zh) * | 1999-02-09 | 2008-10-15 | 理化学研究所 | 肿瘤疫苗 |
| AU4935700A (en) * | 1999-05-21 | 2000-12-12 | Onyvax Limited | New vaccine formulations-3 |
| US8409564B2 (en) | 1999-10-05 | 2013-04-02 | Universite De Montreal | Rhodamine derivatives for photodynamic diagnosis and treatment |
| RU2152800C1 (ru) * | 1999-12-08 | 2000-07-20 | Зыбин Дмитрий Владимирович | Способ культивирования и модификации гетерогенных клеток млекопитающих |
| RU2192884C2 (ru) * | 2000-11-09 | 2002-11-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Вакцина для стимуляции противоопухолевого иммунитета |
| US20050002951A1 (en) * | 2001-09-28 | 2005-01-06 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
| US7176022B2 (en) | 2002-12-20 | 2007-02-13 | Cell Genesys, Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
| EP1701740A4 (en) * | 2003-12-05 | 2010-03-31 | Univ Montreal | IMMUNOLOGICAL COMPOUNDS FOR THE PREVENTION, PROTECTION, PROPHYLAXIS OR TREATMENT OF IMMUNOLOGICAL DISEASES, INFECTIONS AND CANCER |
| GB0601598D0 (en) | 2006-01-26 | 2006-03-08 | Stathopoulos Apostolos | Method |
| RU2392316C1 (ru) * | 2008-12-26 | 2010-06-20 | Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН | КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Ksen, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН |
| AU2012257377B2 (en) | 2011-05-17 | 2017-09-07 | Hadasit Medical Research Services And Development Ltd. | Allogeneic tumor cell vaccination |
| AU2014203896B2 (en) * | 2013-01-07 | 2018-05-31 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cutaneous T cell lymphoma |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4505900A (en) * | 1982-05-26 | 1985-03-19 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
| US4877611A (en) * | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
-
1989
- 1989-09-22 WO PCT/US1989/004139 patent/WO1990003183A1/en not_active Ceased
- 1989-09-22 AU AU43381/89A patent/AU4338189A/en not_active Abandoned
- 1989-09-22 JP JP1510450A patent/JPH04501663A/ja active Pending
- 1989-09-22 ES ES8903606A patent/ES2019728A6/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04501663A (ja) | 1992-03-26 |
| AU4338189A (en) | 1990-04-18 |
| WO1990003183A1 (en) | 1990-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-09-22 |