ES2026190T3 - Conjugados macromoleculares de hemoglobina, su procedimiento de fabricacion y sus aplicaciones. - Google Patents

Conjugados macromoleculares de hemoglobina, su procedimiento de fabricacion y sus aplicaciones.

Info

Publication number
ES2026190T3
ES2026190T3 ES198787401559T ES87401559T ES2026190T3 ES 2026190 T3 ES2026190 T3 ES 2026190T3 ES 198787401559 T ES198787401559 T ES 198787401559T ES 87401559 T ES87401559 T ES 87401559T ES 2026190 T3 ES2026190 T3 ES 2026190T3
Authority
ES
Spain
Prior art keywords
hemoglobin
polymer
pct
macromolecular
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787401559T
Other languages
English (en)
Inventor
Michele Leonard
Edith Dellacherie
Jean Maurice Leon Neel
Claude Vigneron
Pierre Labrude
Francois Bonneaux
Daniel Sacco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Application granted granted Critical
Publication of ES2026190T3 publication Critical patent/ES2026190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

LA INVENCION TIENE POR OBJETO UN CONJUGADO MACROMOLECULAR HIDROSOLUBLE DE HEMOGLOBINA CARACTERIZADO EN QUE ESTA CONSTITUIDO DE UNA PARTE POR LA HEMOGLOBINA, DE OTRA PARTE, POR UN POLIMERO P HIDROSOLUBLE QUE COMPORTA GRUPOS POLARES, DICHO CONJUGADO MACROMOLECULAR COMPORTA SITIOS Z LIGADOS SOBRE EL POLIMERO P Y QUE CONTIENEN AL MENOS UNA CARGA NEGATIVA LLEVADA POR EJEMPLO POR GRUPOS SULFATOS, EL POLIMERO P ESTA RELIGADO A LA HEMOGLOBINA. DE UNA PARTE, POR EL INTERMEDIARIO DE AL MENOS UNA UNION ESTABLE ENTRE AL MENOS UNO DE LOS SITIOS Z LLEVADOS POR EL POLIMERO Y LA HEMOGLOBINA, Y DE OTRA PARTE, POR EL INTERMEDIARIO DE AL MENOS UNA UNION COVALENTE ESTABLE ENTRE EL POLIMERO Y LA HEMOGLOBINA, O ENTRE AL MENOS UNO DE LOS SITIOS Z LLEVADOS POR EL POLIMERO Y LA HEMOGLOBINA. LOS CONJUGADOS MACROMOLECULARES, SEGUN LA INVENCION PRESENTANPARA EL OXIGENO UNA AFINIDAD INFERIOR A LA DE LA HEMOGLOBINA LIBRE.
ES198787401559T 1986-07-02 1987-07-02 Conjugados macromoleculares de hemoglobina, su procedimiento de fabricacion y sus aplicaciones. Expired - Lifetime ES2026190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8609625A FR2600894B1 (fr) 1986-07-02 1986-07-02 Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications

Publications (1)

Publication Number Publication Date
ES2026190T3 true ES2026190T3 (es) 1992-04-16

Family

ID=9336999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787401559T Expired - Lifetime ES2026190T3 (es) 1986-07-02 1987-07-02 Conjugados macromoleculares de hemoglobina, su procedimiento de fabricacion y sus aplicaciones.

Country Status (10)

Country Link
US (1) US5079337A (es)
EP (1) EP0259197B1 (es)
JP (1) JPH01500524A (es)
AT (1) ATE67673T1 (es)
CA (1) CA1328602C (es)
DE (1) DE3773309D1 (es)
ES (1) ES2026190T3 (es)
FR (1) FR2600894B1 (es)
GR (1) GR3003240T3 (es)
WO (1) WO1988000055A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2630329B1 (fr) * 1988-04-20 1991-07-05 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
FR2680369B1 (fr) * 1991-08-14 1993-11-05 Pasteur Merieux Serums Vaccins Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
EP0767675A4 (en) * 1995-04-10 1998-08-05 Baxter Int USE OF CROSS-LINKED HEMOGLOBIN IN THE TREATMENT OF SUBARACHNOIDAL BLEEDING
US5900402A (en) * 1997-05-29 1999-05-04 Enzon, Inc. Method of reducing side effects associated with administration of oxygen-carrying proteins
US5981710A (en) * 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
US6018035A (en) * 1997-07-21 2000-01-25 Baxter International Inc. Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
AR020650A1 (es) * 1998-08-10 2002-05-22 Poly Med Inc Polimeros fosforilados y conjugados de los mismos
US8614291B2 (en) * 1999-08-10 2013-12-24 Poly-Med, Inc. Phosphorylated polymers and conjugates thereof
JP2003507430A (ja) * 1999-08-25 2003-02-25 ジーエムピー カンパニーズ，インコーポレーテッド 哺乳動物中で酸素運搬を向上する薬剤
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
US6619586B1 (en) 2000-11-30 2003-09-16 Barnes, Iii Alfred C. Thermal airship buoyancy controller
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
BR0314227A (pt) * 2002-09-11 2005-10-25 Fresenius Kabi De Gmbh Derivados de amido de hidroxialquila
DE10242076A1 (de) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh HAS-Allergen-Konjugate
US7538092B2 (en) * 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
PL1660134T3 (pl) * 2003-08-08 2011-05-31 Fresenius Kabi Deutschland Gmbh Koniugaty hydroksyalkiloskrobi i G-CSF
BRPI0412671A (pt) * 2003-08-08 2006-10-03 Fresenius Kabi De Gmbh conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
JP5191729B2 (ja) * 2004-03-11 2013-05-08 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
WO2005092369A2 (en) * 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyethyl starch and erythropoietin
WO2005103080A2 (en) * 2004-04-21 2005-11-03 Albert Einstein College Of Medicine Of Yeshiva University Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
CN101137396A (zh) * 2005-03-11 2008-03-05 弗雷泽纽斯卡比德国有限公司 由无活性初始材料制备生物活性糖蛋白
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
FR2921807B1 (fr) * 2007-10-05 2011-04-22 Fabien Andrieux Procede de preparation d'une boisson a base d'eau et d'un additif liquide et kit pour la preparation d'une telle boisson
EP2070950A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
EP2070951A1 (en) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Method for producing a hydroxyalkyl starch derivatives with two linkers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
JPS5716815A (en) * 1980-07-02 1982-01-28 Ajinomoto Co Inc Oxygen transporting agent for artificial blood
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2551660B1 (fr) * 1983-09-13 1986-11-14 Centre Nat Rech Scient Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
DE3340592A1 (de) * 1983-11-10 1985-05-23 B. Braun Melsungen Ag, 3508 Melsungen Konjugate makromolekularer verbindungen an haemoglobine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3636590A1 (de) * 1986-10-28 1988-05-26 Braun Melsungen Ag Blutersatzmittel

Also Published As

Publication number Publication date
FR2600894A1 (fr) 1988-01-08
US5079337A (en) 1992-01-07
JPH01500524A (ja) 1989-02-23
EP0259197A1 (fr) 1988-03-09
DE3773309D1 (de) 1991-10-31
EP0259197B1 (fr) 1991-09-25
FR2600894B1 (fr) 1989-01-13
GR3003240T3 (en) 1993-02-17
CA1328602C (fr) 1994-04-19
WO1988000055A1 (fr) 1988-01-14
ATE67673T1 (de) 1991-10-15

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