ES2032271T1 - Nuevos esteres alilicos y su aplicacion para formar sistemas de fase solida para reacciones en fase solida. reserva del art. 167.2 cpe. - Google Patents
Nuevos esteres alilicos y su aplicacion para formar sistemas de fase solida para reacciones en fase solida. reserva del art. 167.2 cpe.Info
- Publication number
- ES2032271T1 ES2032271T1 ES199090116413T ES90116413T ES2032271T1 ES 2032271 T1 ES2032271 T1 ES 2032271T1 ES 199090116413 T ES199090116413 T ES 199090116413T ES 90116413 T ES90116413 T ES 90116413T ES 2032271 T1 ES2032271 T1 ES 2032271T1
- Authority
- ES
- Spain
- Prior art keywords
- solid phase
- group
- alilic
- rest
- cpe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007790 solid phase Substances 0.000 title abstract 4
- 238000003746 solid phase reaction Methods 0.000 title 1
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229910052727 yttrium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Silicon Polymers (AREA)
- Saccharide Compounds (AREA)
Abstract
EL INVENTO SE REFIERE A UN ESTER ALILICO QUE PRESENTA LA FORMULA (I), PUEDE REACCIONAR CON UN PORTADOR (F) QUE CONTIENE UN GRUPO FUNCIONAL B, SE UTILIZA PARA LA SINTESIS DE SISTEMAS DE FASES SOLIDAS QUE CONTIENEN CADENAS LATERALES ALILICAS, SE OBTIENE EN SOLUCION EN FORMA SENCILLA Y SE ENLAZA CON UN SOPORTE SOLIDO, DESCRIBE LA APLICACION DE FASE SOLIDA PRODUCIDA PARA OBTENER EN FASE SOLIDA PEPTIDO Y GLICOPEPTIDO Y RES/A EL PEPTIDO Y GLICOPEPTIDO OBTENIDOS QUE PUEDE DISOCIARSE A PARTIR DE SOPORTES POLIMEROS Y EN CONDICIONES SUAVES EN DONDE NO SE PRESENTA NINGUNA DISOCIACION EN LAS CONFORMACIONES GLICOSIDICAS O EN AMONERIZACION. SIENDO: A UN GRUPO; A Y B REACCIONAN BAJO CONDENSACION, ADICION Y CONFORMACION DE UN ENLACE ENTRE EL SOPORTE MATERIAL Y EL RESTO DE FORMULA (II); R1 Y R2 IGUALES O DIFERENTES HIDROGENO, ALQUILO, ARILO O HALOGENO; R3 UN GRUPO DE ENLACE, R UN RESTO ORGANICO; ACILO UN GRUPO ACILOXI, EL RESTO DE UN ACIDO CARBONICO ALIFATICO O RCO-; X UN GRUPO ACILOXI; E Y , O, S O NH.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3928909 | 1989-08-31 | ||
| DE3938850A DE3938850A1 (de) | 1989-08-31 | 1989-11-23 | Neue allylester und ihre verwendung zum aufbau von festphasensystemen fuer festphasenreaktionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2032271T1 true ES2032271T1 (es) | 1993-02-01 |
Family
ID=25884632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES199090116413T Pending ES2032271T1 (es) | 1989-08-31 | 1990-08-27 | Nuevos esteres alilicos y su aplicacion para formar sistemas de fase solida para reacciones en fase solida. reserva del art. 167.2 cpe. |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5214195A (es) |
| EP (1) | EP0415331A3 (es) |
| DE (1) | DE3938850A1 (es) |
| ES (1) | ES2032271T1 (es) |
| GR (1) | GR910300100T1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4220350A1 (de) * | 1992-06-22 | 1993-12-23 | Orpegen Med Molekularbioforsch | HYCRAM-Linker |
| EP0623626B1 (en) * | 1993-04-05 | 1999-09-01 | Perseptive Biosystems, Inc. | Automated allyl deprotection in solid-phase synthesis |
| US5578740A (en) * | 1994-12-23 | 1996-11-26 | The Dow Chemical Company | Process for preparation of epoxy compounds essentially free of organic halides |
| JPH10511340A (ja) * | 1995-02-09 | 1998-11-04 | ブリガム アンド ウィメンズ ホスピタル | ゲル生成ポリペプチド誘導体 |
| US20090264594A1 (en) * | 2005-12-05 | 2009-10-22 | Solvay (Societe Anonyme) | Aromatic Sulfone Polymer Composition Comprising Tetrafluoroethylene Polymer Particles |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154439C3 (de) * | 1971-11-02 | 1975-10-02 | H.F. & Ph. F. Reemtsma, 2000 Hamburg | Verfahren zur Herstellung von substituierten Delta alpha, beta-Butenoliden durch Cyclisierung von 4-Acyloxybuten-2 -Säureestern |
| JPS5618941A (en) * | 1979-07-25 | 1981-02-23 | Toray Ind Inc | Production of 2,2,2-trichloroethyl methacrylate |
| DE3803545A1 (de) * | 1987-06-19 | 1988-12-29 | Orpegen Med Molekularbioforsch | Allylische seitenketten enthaltendes festphasensystem, verfahren zu seiner herstellung und seine verwendung in festphasenreaktionen |
| US5124448A (en) * | 1989-02-23 | 1992-06-23 | Merck & Co., Inc. | Deblocking process for allyl esters with regeneratable polymer supported Pd(O) |
-
1989
- 1989-11-23 DE DE3938850A patent/DE3938850A1/de not_active Ceased
-
1990
- 1990-08-27 ES ES199090116413T patent/ES2032271T1/es active Pending
- 1990-08-27 EP EP19900116413 patent/EP0415331A3/de not_active Ceased
- 1990-08-31 US US07/576,366 patent/US5214195A/en not_active Expired - Fee Related
-
1991
- 1991-05-03 US US07/695,424 patent/US5324786A/en not_active Expired - Fee Related
- 1991-12-10 GR GR91300100T patent/GR910300100T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0415331A2 (de) | 1991-03-06 |
| US5324786A (en) | 1994-06-28 |
| DE3938850A1 (de) | 1991-03-07 |
| EP0415331A3 (en) | 1991-08-07 |
| GR910300100T1 (en) | 1991-12-10 |
| US5214195A (en) | 1993-05-25 |
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