ES2032514T3 - Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo. - Google Patents

Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo.

Info

Publication number
ES2032514T3
ES2032514T3 ES198888116665T ES88116665T ES2032514T3 ES 2032514 T3 ES2032514 T3 ES 2032514T3 ES 198888116665 T ES198888116665 T ES 198888116665T ES 88116665 T ES88116665 T ES 88116665T ES 2032514 T3 ES2032514 T3 ES 2032514T3
Authority
ES
Spain
Prior art keywords
agents
active component
derivative
radiosensitizing
understand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888116665T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Tomoyuki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Application granted granted Critical
Publication of ES2032514T3 publication Critical patent/ES2032514T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN NUEVO DERIVADO HETEROCICLICO DE FORMULA (R2O)2 - O - R1, DONDE R1 REPRESENTA - N - N - NO2 O O2N - N3 - Y R2 REPRESENTA HIDROGENO O ACIL. CUANDO R2 ES ACIL, EL DERIVADO SE PUEDE PREPARAR, POR EJEMPLO, CON LOS SIGUIENTES PROCESOS: (R4O) - O - OR4 + R1H CATALITICO ==> (R4O)2 - O - R1 + R4OH DONDE R4 ES ACIL Y R1 YA SE DESCRIBIO. EL DERIVADO ES MENOS TOXICO Y TIENE RADIOSENSIBILIZANTES ACTIVOS Y ANTIVIRICOS AUNQUE CON UNA MENOR CONCENTRACION. SE DESCUBRE TAMBIEN QUE LOS AGENTES RADIOSENSIBILIZANTES Y ANTIVIRICOS CONTIENEN EL DERIVADO COMO UN COMPONENTE ACTIVO
ES198888116665T 1987-10-22 1988-10-07 Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo. Expired - Lifetime ES2032514T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62267485A JPH0819111B2 (ja) 1987-10-22 1987-10-22 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
ES2032514T3 true ES2032514T3 (es) 1993-02-16

Family

ID=17445505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888116665T Expired - Lifetime ES2032514T3 (es) 1987-10-22 1988-10-07 Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo.

Country Status (7)

Country Link
US (2) US4945102A (es)
EP (1) EP0312858B1 (es)
JP (1) JPH0819111B2 (es)
KR (1) KR960011379B1 (es)
CA (1) CA1329392C (es)
DE (1) DE3868308D1 (es)
ES (1) ES2032514T3 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389613A (en) * 1979-09-21 1995-02-14 Roussel Uclaf Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis
JP2799368B2 (ja) * 1990-01-10 1998-09-17 ポーラ化成工業株式会社 抗原虫剤
JP2626727B2 (ja) * 1990-01-26 1997-07-02 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤
WO1992019264A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Biomodulators as universal imaging agents
US5532380A (en) * 1992-12-18 1996-07-02 Pola Chemical Industries, Inc. R,R,S,S-2-nitroimidazole derivatives
US5535785A (en) * 1994-09-08 1996-07-16 Nypro, Inc. Luer-activated check valve
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
JP4116793B2 (ja) * 1999-09-13 2008-07-09 良尋 高井 新規ニトロイミダゾール誘導体及びこれを含む画像診断薬
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
CN102532321B (zh) 2004-06-18 2018-10-12 Ambrx公司 新颖抗原结合多肽和其用途
US8003625B2 (en) 2005-06-29 2011-08-23 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
US8552048B2 (en) * 2006-12-26 2013-10-08 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
JP5213178B2 (ja) * 2007-01-23 2013-06-19 株式会社ポーラファルマ ２−ニトロイミダゾール誘導体の製造法
EP2192922A4 (en) 2007-09-17 2010-09-29 Univ California INTERNATIONALIZING HUMAN MONOCLONAL ANTIBODIES TO PROMOTE IN SITU ON PROSTATAZELLES
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
US10981953B2 (en) 2013-12-26 2021-04-20 Toagosei Co, Ltd. Method for promoting expression of calreticulin, and synthetic peptide for use in method for promoting expression of calreticulin
JP6872713B2 (ja) 2015-05-29 2021-05-19 東亞合成株式会社 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用
ES2975747T3 (es) 2015-11-30 2024-07-12 Univ California Administración de carga útil específica de tumor y activación inmunitaria utilizando un anticuerpo humano que se dirige a un antígeno de superficie celular de tumor altamente específico
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
WO2018089807A2 (en) 2016-11-11 2018-05-17 The Regents Of The University Of California Anti-cd46 antibodies and methods of use
WO2020102777A1 (en) 2018-11-16 2020-05-22 Virtuoso Binco, Inc. Cd38 and icam1 antibodies and uses thereof
IL319265A (en) 2018-12-21 2025-04-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and their uses
WO2021188390A1 (en) 2020-03-19 2021-09-23 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy
WO2021195469A1 (en) 2020-03-27 2021-09-30 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
AU2021320333A1 (en) 2020-08-07 2023-03-30 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof
MX2024003266A (es) 2021-09-16 2024-04-03 Avidity Biosciences Inc Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5614774A (en) * 1979-07-17 1981-02-13 Sanyo Electric Co Ltd Transmission and recording system for facsimile picture signal
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
US4613604A (en) 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
EP0212558B1 (en) * 1985-08-15 1991-12-04 Asahi Denka Kogyo Kabushiki Kaisha A radiation sensitizer
JPS6360929A (ja) * 1986-08-29 1988-03-17 Yodogawa Seiyaku Kk 抗腫瘍剤
JPS63165373A (ja) * 1986-08-29 1988-07-08 Yodogawa Seiyaku Kk アサイクリツクヌクレオシドサイクリツクホスホラアミデ−トとその関連化合物

Also Published As

Publication number Publication date
DE3868308D1 (de) 1992-03-19
EP0312858A1 (en) 1989-04-26
JPH01110675A (ja) 1989-04-27
JPH0819111B2 (ja) 1996-02-28
US4945102A (en) 1990-07-31
US5064849A (en) 1991-11-12
EP0312858B1 (en) 1992-02-05
CA1329392C (en) 1994-05-10
KR890006599A (ko) 1989-06-14
KR960011379B1 (ko) 1996-08-22

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