ES2032514T3 - Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo. - Google Patents

Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo.

Info

Publication number
ES2032514T3
ES2032514T3 ES198888116665T ES88116665T ES2032514T3 ES 2032514 T3 ES2032514 T3 ES 2032514T3 ES 198888116665 T ES198888116665 T ES 198888116665T ES 88116665 T ES88116665 T ES 88116665T ES 2032514 T3 ES2032514 T3 ES 2032514T3
Authority
ES
Spain
Prior art keywords
agents
active component
derivative
radiosensitizing
understand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888116665T
Other languages
English (en)
Inventor
Toshimitsu Suzuki
Masakazu Sakaguchi
Yoshiyuki Miyata
Tomoyuki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Application granted granted Critical
Publication of ES2032514T3 publication Critical patent/ES2032514T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN NUEVO DERIVADO HETEROCICLICO DE FORMULA (R2O)2 - O - R1, DONDE R1 REPRESENTA - N - N - NO2 O O2N - N3 - Y R2 REPRESENTA HIDROGENO O ACIL. CUANDO R2 ES ACIL, EL DERIVADO SE PUEDE PREPARAR, POR EJEMPLO, CON LOS SIGUIENTES PROCESOS: (R4O) - O - OR4 + R1H CATALITICO ==> (R4O)2 - O - R1 + R4OH DONDE R4 ES ACIL Y R1 YA SE DESCRIBIO. EL DERIVADO ES MENOS TOXICO Y TIENE RADIOSENSIBILIZANTES ACTIVOS Y ANTIVIRICOS AUNQUE CON UNA MENOR CONCENTRACION. SE DESCUBRE TAMBIEN QUE LOS AGENTES RADIOSENSIBILIZANTES Y ANTIVIRICOS CONTIENEN EL DERIVADO COMO UN COMPONENTE ACTIVO
ES198888116665T 1987-10-22 1988-10-07 Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo. Expired - Lifetime ES2032514T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62267485A JPH0819111B2 (ja) 1987-10-22 1987-10-22 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤

Publications (1)

Publication Number Publication Date
ES2032514T3 true ES2032514T3 (es) 1993-02-16

Family

ID=17445505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888116665T Expired - Lifetime ES2032514T3 (es) 1987-10-22 1988-10-07 Derivados heterociclicos, su preparacion, y agentes radiosensibilizantes y agentes antivirales que los comprenden como su componente activo.

Country Status (7)

Country Link
US (2) US4945102A (es)
EP (1) EP0312858B1 (es)
JP (1) JPH0819111B2 (es)
KR (1) KR960011379B1 (es)
CA (1) CA1329392C (es)
DE (1) DE3868308D1 (es)
ES (1) ES2032514T3 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389613A (en) * 1979-09-21 1995-02-14 Roussel Uclaf Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis
JP2799368B2 (ja) * 1990-01-10 1998-09-17 ポーラ化成工業株式会社 抗原虫剤
KR927003539A (ko) * 1990-01-26 1992-12-18 스즈끼 쯔네시 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제
WO1992019264A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Biomodulators as universal imaging agents
WO1994014778A1 (fr) * 1992-12-18 1994-07-07 Pola Chemical Industries, Inc. Derive optiquement actif de 2-nitroimidazole, son procede de production, et intermediaire pour sa production
US5535785A (en) * 1994-09-08 1996-07-16 Nypro, Inc. Luer-activated check valve
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5929104A (en) * 1997-04-02 1999-07-27 Pola Chemical Industries, Inc. Method for inducing apoptosis of cancer cell
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
ATE293607T1 (de) 1999-09-13 2005-05-15 Pola Chem Ind Inc Nitroimidazolderivate und diese enthaltende diagnostische bilderzeugungsmittel
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
KR101699142B1 (ko) 2004-06-18 2017-01-23 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
CN102746336B (zh) 2005-06-29 2015-08-19 施瑞修德制药公司 氨基磷酸酯烷化剂前体药物
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
EP2114157B1 (en) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
WO2008090731A1 (ja) 2007-01-23 2008-07-31 Pola Pharma Inc. ２－ニトロイミダゾール誘導体の製造法
CA2699394C (en) 2007-09-17 2020-03-24 The Regents Of The University Of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
JP6654899B2 (ja) 2013-12-26 2020-02-26 東亞合成株式会社 カルレティキュリンの発現促進方法および該方法に用いられる合成ペプチド
JP6872713B2 (ja) 2015-05-29 2021-05-19 東亞合成株式会社 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用
EP3383920B1 (en) 2015-11-30 2024-01-10 The Regents of the University of California Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
ES3005158T3 (en) 2016-11-11 2025-03-14 Univ California Anti-cd46 antibodies and methods of use
US12583932B2 (en) 2018-11-16 2026-03-24 Virtuoso Binco, Inc. CD38 and ICAM1 antibodies and uses thereof
IL312067B2 (en) 2018-12-21 2025-08-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and uses thereof
US11555190B2 (en) 2020-03-19 2023-01-17 Avidity Biosciences, Inc. Compositions and methods of treating Facioscapulohumeral muscular dystrophy
AU2021241682B2 (en) 2020-03-27 2026-02-12 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
EP4192511A1 (en) 2020-08-07 2023-06-14 Fortis Therapeutics, Inc. Immunoconjugates targeting cd46 and methods of use thereof
MX2024003266A (es) 2021-09-16 2024-04-03 Avidity Biosciences Inc Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5614774A (en) * 1979-07-17 1981-02-13 Sanyo Electric Co Ltd Transmission and recording system for facsimile picture signal
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59139363A (ja) * 1983-01-31 1984-08-10 Kayaku:Kk ２−ニトロイミダゾ−ル誘導体およびその製造法
US4613604A (en) * 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
DE3682723D1 (de) * 1985-08-15 1992-01-16 Asahi Denka Kogyo Kk Strahlungssensibilisator.
JPS63165373A (ja) * 1986-08-29 1988-07-08 Yodogawa Seiyaku Kk アサイクリツクヌクレオシドサイクリツクホスホラアミデ−トとその関連化合物
JPS6360929A (ja) * 1986-08-29 1988-03-17 Yodogawa Seiyaku Kk 抗腫瘍剤

Also Published As

Publication number Publication date
US5064849A (en) 1991-11-12
DE3868308D1 (de) 1992-03-19
US4945102A (en) 1990-07-31
JPH01110675A (ja) 1989-04-27
CA1329392C (en) 1994-05-10
EP0312858B1 (en) 1992-02-05
JPH0819111B2 (ja) 1996-02-28
KR890006599A (ko) 1989-06-14
EP0312858A1 (en) 1989-04-26
KR960011379B1 (ko) 1996-08-22

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