ES2034221T3 - Agentes antialergicos y antiinflamatorios de dihidropiridina. - Google Patents

Agentes antialergicos y antiinflamatorios de dihidropiridina.

Info

Publication number
ES2034221T3
ES2034221T3 ES88304691T ES88304691T ES2034221T3 ES 2034221 T3 ES2034221 T3 ES 2034221T3 ES 88304691 T ES88304691 T ES 88304691T ES 88304691 T ES88304691 T ES 88304691T ES 2034221 T3 ES2034221 T3 ES 2034221T3
Authority
ES
Spain
Prior art keywords
alkyl
allergic
dihydropyridine
arylalcoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88304691T
Other languages
English (en)
Inventor
Kelvin Dr Cooper
Michael Johnathan Dr Fray
Kenneth Dr Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Pfizer Inc
Original Assignee
Pfizer Ltd Great Britain
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain, Pfizer Inc filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of ES2034221T3 publication Critical patent/ES2034221T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R ES FENILO O FENILO SUSTITUIDO POR NITRO, HALO, ALQUILO, ALCOXI, FLUOROACOXI, ARILALCOXI, ALQUILTIO, ALQUILSULFONILO (TENIENDO LOS ALQUILO Y ALCOXI DE 1 A 4 C), OH, CF3 O CIANO; R1 Y R2 SON H O ALQUILO DE 1 A 6 C O FORMAN JUNTOS DIVERSOS GRUPOS HETEROCICLICOS; R3 ES OH, ALQUILOXI, ARILALCOXI O NR4R5 EN DONDE R4 Y R5 TIENEN DIFERENTES SIGNIFICADOS QUE SE INDICAN; Y ES UN GRUPO ALQUILENO DE 2 A 8 C, Y X ES 1-, 2- O 3-IMIZAZOPIRIDILO OPCIONALMENTE SUSTITUIDO. ESTOS COMPUESTOS SON ANTAGONISTAS DE PAF POR LO QUE SON UTILES EN EL TRATAMIENTO DE ANTAGONISTAS DE PAF POR LO QUE SON UTILES EN EL TRATAMIENTO DE AFECCIONES INFLAMATORIAS ALERGICAS Y DE HIPERSECRECION.
ES88304691T 1987-05-30 1988-05-24 Agentes antialergicos y antiinflamatorios de dihidropiridina. Expired - Lifetime ES2034221T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712747A GB8712747D0 (en) 1987-05-30 1987-05-30 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2034221T3 true ES2034221T3 (es) 1995-04-01

Family

ID=10618181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88304691T Expired - Lifetime ES2034221T3 (es) 1987-05-30 1988-05-24 Agentes antialergicos y antiinflamatorios de dihidropiridina.

Country Status (16)

Country Link
US (1) US4851412A (es)
EP (1) EP0294074B1 (es)
JP (1) JPS63310887A (es)
KR (1) KR880013920A (es)
AT (1) ATE74602T1 (es)
AU (1) AU1671288A (es)
CA (1) CA1302410C (es)
DE (1) DE3869833D1 (es)
DK (1) DK290688A (es)
ES (1) ES2034221T3 (es)
FI (1) FI88797C (es)
GB (1) GB8712747D0 (es)
GR (1) GR3004540T3 (es)
HU (1) HUT47933A (es)
IL (1) IL86529A0 (es)
PT (1) PT87604B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY104933A (en) * 1987-09-30 1994-07-30 Pfizer Ltd Platelet activating factor antagonists
GB8906168D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
GB8906324D0 (en) * 1989-03-20 1989-05-04 Pfizer Ltd 1,4-dihydropyridines
US5144715A (en) * 1989-08-18 1992-09-08 Matsushita Electric Industrial Co., Ltd. Vacuum cleaner and method of determining type of floor surface being cleaned thereby
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
CA2333770A1 (en) * 1998-06-04 1999-12-09 Abbott Laboratories Cell adhesion-inhibiting antinflammatory compounds
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
WO2000075145A1 (en) * 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
DE102016101111B3 (de) * 2016-01-22 2017-04-13 Phoenix Contact Gmbh & Co. Kg Drucker zur Bedruckung von Bedruckungsobjekten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE20064T1 (de) * 1982-07-22 1986-06-15 Pfizer Anti-ischaemische und antihypertensive dihydropyridin-derivate.
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
DE3531498A1 (de) * 1985-09-04 1987-03-05 Bayer Ag Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8620880D0 (en) * 1986-08-29 1986-10-08 Pfizer Ltd Therapeutic agents
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
NO874194L (no) * 1986-11-07 1988-05-09 Pfizer Ltd Fremgangsmaate ved fremstilling av dihydro-pyridinderivater

Also Published As

Publication number Publication date
IL86529A0 (en) 1988-11-15
EP0294074B1 (en) 1992-04-08
GB8712747D0 (en) 1987-07-01
FI882538A0 (fi) 1988-05-30
DK290688A (da) 1988-12-01
FI882538A7 (fi) 1988-12-01
US4851412A (en) 1989-07-25
CA1302410C (en) 1992-06-02
EP0294074A1 (en) 1988-12-07
DE3869833D1 (de) 1992-05-14
HUT47933A (en) 1989-04-28
PT87604A (pt) 1988-06-01
FI88797C (fi) 1993-07-12
JPS63310887A (ja) 1988-12-19
PT87604B (pt) 1992-09-30
AU1671288A (en) 1988-12-01
KR880013920A (ko) 1988-12-22
DK290688D0 (da) 1988-05-27
GR3004540T3 (es) 1993-04-28
FI88797B (fi) 1993-03-31
ATE74602T1 (de) 1992-04-15
JPH0587072B2 (es) 1993-12-15

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