PT87604A - Process for preparing dihydropyridine anti-allergic and anti-inflammatory agents - Google Patents

Process for preparing dihydropyridine anti-allergic and anti-inflammatory agents

Info

Publication number: PT87604A
Authority: PT; Portugal
Prior art keywords: alkyl; alkoxy; piperazinyl; aryl; group
Prior art date: 1987-05-30

Application number

PT87604A

Other languages

English (en)

Other versions

PT87604B (pt

Inventor

Kelvin Cooper

Michael Jonathan Fray

Kenneth Richardson

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-30

Filing date

1988-05-27

Publication date

1988-06-01

1988-05-27 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1988-06-01 Publication of PT87604A publication Critical patent/PT87604A/pt

1992-09-30 Publication of PT87604B publication Critical patent/PT87604B/pt

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
230000003266 anti-allergic effect Effects 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000000043 antiallergic agent Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
-1 piperidino, morpholino, piperazinyl Chemical group 0.000 abstract 4
125000004193 piperazinyl group Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

PT87604A 1987-05-30 1988-05-27 Processo para a preparacao de agentes anti-alergicos e anti-inflamatorios di-hidropiridinicos PT87604B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878712747A GB8712747D0 (en)	1987-05-30	1987-05-30	Therapeutic agents

Publications (2)

Publication Number	Publication Date
PT87604A true PT87604A (pt)	1988-06-01
PT87604B PT87604B (pt)	1992-09-30

Family

ID=10618181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT87604A PT87604B (pt)	1987-05-30	1988-05-27	Processo para a preparacao de agentes anti-alergicos e anti-inflamatorios di-hidropiridinicos

Country Status (16)

Country	Link
US (1)	US4851412A (pt)
EP (1)	EP0294074B1 (pt)
JP (1)	JPS63310887A (pt)
KR (1)	KR880013920A (pt)
AT (1)	ATE74602T1 (pt)
AU (1)	AU1671288A (pt)
CA (1)	CA1302410C (pt)
DE (1)	DE3869833D1 (pt)
DK (1)	DK290688A (pt)
ES (1)	ES2034221T3 (pt)
FI (1)	FI88797C (pt)
GB (1)	GB8712747D0 (pt)
GR (1)	GR3004540T3 (pt)
HU (1)	HUT47933A (pt)
IL (1)	IL86529A0 (pt)
PT (1)	PT87604B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY104933A (en) *	1987-09-30	1994-07-30	Pfizer Ltd	Platelet activating factor antagonists
GB8906168D0 (en) *	1989-03-17	1989-05-04	Pfizer Ltd	Therapeutic agents
GB8906324D0 (en) *	1989-03-20	1989-05-04	Pfizer Ltd	1,4-dihydropyridines
US5144715A (en) *	1989-08-18	1992-09-08	Matsushita Electric Industrial Co., Ltd.	Vacuum cleaner and method of determining type of floor surface being cleaned thereby
KR20010052570A (ko) *	1998-06-04	2001-06-25	스티븐 에프. 웨인스톡	세포 유착을 억제하는 소염성 화합물
US6232320B1 (en)	1998-06-04	2001-05-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory compounds
TW526202B (en) *	1998-11-27	2003-04-01	Shionogi & Amp Co	Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
HK1045306A1 (zh) *	1999-06-03	2002-11-22	Abbott Laboratories	抑制细胞黏附的抗炎化合物
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (en)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Glutathione-based drug delivery system
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
DE102016101111B3 (de) *	2016-01-22	2017-04-13	Phoenix Contact Gmbh & Co. Kg	Drucker zur Bedruckung von Bedruckungsobjekten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE20064T1 (de) *	1982-07-22	1986-06-15	Pfizer	Anti-ischaemische und antihypertensive dihydropyridin-derivate.
HU197881B (en) *	1982-08-06	1989-06-28	Banyu Pharma Co Ltd	Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
PH19166A (en) *	1982-09-04	1986-01-16	Pfizer	Dihydropyridined,pharmaceutical compositions and method of use
DE3531498A1 (de) *	1985-09-04	1987-03-05	Bayer Ag	Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8620880D0 (en) *	1986-08-29	1986-10-08	Pfizer Ltd	Therapeutic agents
US4804658A (en) *	1986-09-15	1989-02-14	G. D. Searle & Co.	Imidazopyridine derivatives and pharmaceutical compositions
NO874194L (no) *	1986-11-07	1988-05-09	Pfizer Ltd	Fremgangsmaate ved fremstilling av dihydro-pyridinderivater

1987
- 1987-05-30 GB GB878712747A patent/GB8712747D0/en active Pending
1988
- 1988-05-24 US US07/198,020 patent/US4851412A/en not_active Expired - Fee Related
- 1988-05-24 EP EP88304691A patent/EP0294074B1/en not_active Expired - Lifetime
- 1988-05-24 AT AT88304691T patent/ATE74602T1/de not_active IP Right Cessation
- 1988-05-24 DE DE8888304691T patent/DE3869833D1/de not_active Expired - Lifetime
- 1988-05-24 ES ES88304691T patent/ES2034221T3/es not_active Expired - Lifetime
- 1988-05-27 PT PT87604A patent/PT87604B/pt not_active IP Right Cessation
- 1988-05-27 DK DK290688A patent/DK290688A/da not_active Application Discontinuation
- 1988-05-27 AU AU16712/88A patent/AU1671288A/en not_active Abandoned
- 1988-05-27 KR KR1019880006235A patent/KR880013920A/ko not_active Ceased
- 1988-05-27 HU HU882708A patent/HUT47933A/hu unknown
- 1988-05-27 IL IL86529A patent/IL86529A0/xx unknown
- 1988-05-30 JP JP63132530A patent/JPS63310887A/ja active Granted
- 1988-05-30 FI FI882538A patent/FI88797C/fi not_active IP Right Cessation
- 1988-05-30 CA CA000568064A patent/CA1302410C/en not_active Expired - Lifetime
1992
- 1992-05-08 GR GR920400882T patent/GR3004540T3/el unknown

Also Published As

Publication number	Publication date
DK290688A (da)	1988-12-01
GB8712747D0 (en)	1987-07-01
FI882538A7 (fi)	1988-12-01
CA1302410C (en)	1992-06-02
EP0294074A1 (en)	1988-12-07
ES2034221T3 (es)	1995-04-01
IL86529A0 (en)	1988-11-15
HUT47933A (en)	1989-04-28
AU1671288A (en)	1988-12-01
KR880013920A (ko)	1988-12-22
FI88797C (fi)	1993-07-12
EP0294074B1 (en)	1992-04-08
JPH0587072B2 (pt)	1993-12-15
ATE74602T1 (de)	1992-04-15
PT87604B (pt)	1992-09-30
DK290688D0 (da)	1988-05-27
DE3869833D1 (de)	1992-05-14
US4851412A (en)	1989-07-25
FI88797B (fi)	1993-03-31
JPS63310887A (ja)	1988-12-19
FI882538A0 (fi)	1988-05-30
GR3004540T3 (pt)	1993-04-28

Legal Events

Date

Code

Title

Description

1992-09-30

FG3A

Patent granted, date of granting

Effective date: 19920309

1995-03-01

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940930

Publication	Publication Date	Title
EP0258033B1 (en)	1993-08-04	Dihydropyridine anti-allergic and anti-inflammatory agents
ATE74602T1 (de)	1992-04-15	Dihydropyridine mit antiallergischer und antiinflammatorischer wirkung.
RU2004120553A (ru)	2005-05-27	Производные никотинамида, полезные в качестве р38-ингибиторов
EP0013612A3 (en)	1980-10-15	(piperidinylalkyl)quinazoline derivatives and intermediates, process for their preparation and pharmaceutical compositions containing them
MY104933A (en)	1994-07-30	Platelet activating factor antagonists
PT89747A (pt)	1989-10-04	Processo para a preparacao de agentes anti-inflamatorios e anti-alergicos di-hidropiridinicos
PT1161424E (pt)	2004-08-31	Novos derivados de diazole como agentes serotonergicos
RU2004118717A (ru)	2005-03-27	Фотохромные оксазиновые соединения и способы их производства
IE870141L (en)	1987-07-21	Dihydropyridine anti-ischaemic antihypertensive¹agents
HUT48201A (en)	1989-05-29	Herbicide comprising anilide derivatives and process for producing such compounds
DE69124392D1 (de)	1997-03-06	Tri(c1-c6 alkoxy)benzolderivat