ES2034888A1 - Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata. - Google Patents

Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata.

Info

Publication number
ES2034888A1
ES2034888A1 ES919101710A ES9101710A ES2034888A1 ES 2034888 A1 ES2034888 A1 ES 2034888A1 ES 919101710 A ES919101710 A ES 919101710A ES 9101710 A ES9101710 A ES 9101710A ES 2034888 A1 ES2034888 A1 ES 2034888A1
Authority
ES
Spain
Prior art keywords
compositions
acid fraction
antagonistic
lipid extracts
new pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919101710A
Other languages
English (en)
Other versions
ES2034888B1 (es
Inventor
Rodero Miguel Angel Salinero
Toral M Angeles Sevilla
Del Corral Jose Maria Miguel
Gomez M Jose Montero
Feliciano Martin Arturo San
Roman Del Barrio Luis San
Gabarro Jose Antonio Poch
Armengol Antonio Manes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus SA
Original Assignee
Laboratorios Madaus Cerafarm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Madaus Cerafarm SA filed Critical Laboratorios Madaus Cerafarm SA
Priority to ES9101710A priority Critical patent/ES2034888B1/es
Priority to EP92500088A priority patent/EP0527101A1/en
Priority to JP4184146A priority patent/JPH05194250A/ja
Priority to US07/911,613 priority patent/US5284873A/en
Publication of ES2034888A1 publication Critical patent/ES2034888A1/es
Application granted granted Critical
Publication of ES2034888B1 publication Critical patent/ES2034888B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PROCEDIMIENTO DE LA PRESENTE INVENCION CONSISTE EN SOMETER EL EXTRACTO LIPIDICO DE LA PLANTA SABAL SERRULATA A UNA SAPONIFICACION EXHAUSTIVA EN MEDIO ACUOSO ALCALINO, ELIMINAR LA FRACCION INSAPONIFICABLE MEDIANTE EXTRACCION CON DISOLVENTES APOLARES, Y RECUPERAR LA FRACCION CONSTITUIDA ESENCIALMENTE POR LOS ACIDOS GRASOS TOTALES MEDIANTE ACIDIFICACION A PH INFERLOR A 4 Y EXTRACCION CON DISOLVENTES APOLARES. LA FRACCION ACIDA TOTAL ASI OBTENIDA MANIFIESTA UNA EFICAZ ACCION BLOQUEANTE DE LOS RECEPTORES X-ADRENERGICOS, DESCONOCIDA HASTA LA FECHA, QUE PERMITE SU EMPLEO EN LA PRECARACION DE COMPOSICIONES FARMACEUTICAS DE UTILIDAD, ENTRE OTRAS, EN EL TRATAMIENTO DE LOS ENFERMOS PROSTATICOS.
ES9101710A 1991-07-11 1991-07-11 Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata. Expired - Fee Related ES2034888B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9101710A ES2034888B1 (es) 1991-07-11 1991-07-11 Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata.
EP92500088A EP0527101A1 (en) 1991-07-11 1992-07-09 New pharmaceutical compositions derived from acid fraction of the lipid extracts of sabal serrulata, with antagonistic adrenergic effect and method to obtain these compositions
JP4184146A JPH05194250A (ja) 1991-07-11 1992-07-10 サバルセルラタのリピド抽出物の酸分画から導かれた新規薬学的組成物及びその組成物を製造する方法
US07/911,613 US5284873A (en) 1991-07-11 1992-07-10 Pharmaceutical compositions derived from the acid fraction of lipid extracts of sabal serrulata, with adrenergic antagonist activity and method of preparing said composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9101710A ES2034888B1 (es) 1991-07-11 1991-07-11 Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata.

Publications (2)

Publication Number Publication Date
ES2034888A1 true ES2034888A1 (es) 1993-04-01
ES2034888B1 ES2034888B1 (es) 1994-02-16

Family

ID=8273084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101710A Expired - Fee Related ES2034888B1 (es) 1991-07-11 1991-07-11 Procedimiento de obtencion de la fraccion acida total de los extractos lipidicos de los frutos del sabal serrulata.

Country Status (4)

Country Link
US (1) US5284873A (es)
EP (1) EP0527101A1 (es)
JP (1) JPH05194250A (es)
ES (1) ES2034888B1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6039950A (en) * 1995-04-14 2000-03-21 University Of Southern California Pharmaceutical grade saw palmetto
NO308197B1 (no) * 1998-01-21 2000-08-14 Fideline Sammensetning og oppløsning derav for Õ minske stress, angst og agressivitet hos pattedyr inneholdende en blanding av fettsyrer eller derivater derav
JP4754688B2 (ja) * 1998-01-21 2011-08-24 フィドゥラン ストレス、不安及び攻撃性を低減するブタ鎮静フェロモン
GB9808796D0 (en) * 1998-04-24 1998-06-24 Rowett Research Services Limit Antithrombotic agents
AUPP379698A0 (en) * 1998-06-01 1998-06-25 Hull, Peter Hugh Using ngali nut oil to treat/relieve the pain of arthritis and other similar conditions
US6759063B2 (en) 1999-09-27 2004-07-06 Anthony L. Almada Methods and compositions for reducing sympathomimetic-induced side effects
US6200573B1 (en) * 1999-12-03 2001-03-13 Starcor Pharmaceuticals, Inc. Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia
US6607755B2 (en) * 2001-06-21 2003-08-19 Michael Donald Farley Anti-aromatase pharmaceutical composition for controlling testosterone/estrone ratios
WO2004064813A1 (en) * 2003-01-13 2004-08-05 Michael Donald Farley Improvements in or relating to anti-aromatase composition
EP1624863A1 (en) * 2003-01-13 2006-02-15 Michael Farley Improvements in or relating to anti-aromatase composition
US20120142776A1 (en) * 2009-04-09 2012-06-07 Leinwand Leslie A Methods and compositions for inducing physiological hypertrophy
GB201015079D0 (en) 2010-09-10 2010-10-27 Helperby Therapeutics Ltd Novel use
ITMI20111284A1 (it) 2011-07-11 2013-01-12 Giovanni Nusca Composizione farmaceutica.
US12551524B2 (en) 2021-08-18 2026-02-17 U.S. Nutraceuticals, Inc. Composition and method having enhanced LSESr to maintain and promote urinary and prostate function in a human

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES394117A1 (es) * 1970-07-23 1974-03-01 Investigations Scient Pharma Procedimiento de preparacion de principios medicinales ac- tivos.
ES438117A1 (es) * 1974-06-03 1977-01-16 Gen Electric Dispositivo protector electrostatico para aparatos inducti- vos electricos.
ES8500622A1 (es) * 1983-07-11 1984-11-01 Euromed S A Procedimiento para la obtencion de extractos farmacologicamente activos de la planta de genero pygeum africanum
JPS60215608A (ja) * 1984-04-11 1985-10-29 Shiseido Co Ltd 養毛料
EP0287000A1 (en) * 1987-04-17 1988-10-19 Consiglio Nazionale Delle Ricerche Pharmaceutical compositions containing higher alcohols for the treatment of prostatic pathologies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480754A1 (fr) * 1980-04-21 1981-10-23 Fabre Sa Pierre Procede d'obtention d'un extrait stable et desodorise de sabal serrulatum antiprostatique
EP0068055B1 (fr) * 1981-06-26 1986-04-02 P.F. Industrie Procédé d'obtention d'un extrait stable et désodorisé de sabal serrulatum antiprostatique
US4486240A (en) * 1983-07-18 1984-12-04 Sciaky Bros., Inc. Method and apparatus for heat treating
FR2605223B1 (fr) * 1986-10-20 1989-09-22 Pf Medicament Compositions therapeutiques stables a base d' huile vegetale hydrophobe et son procede de preparation
FR2645943B1 (fr) * 1989-04-18 1991-07-26 Ouest Produits Isolants Ste In Revetement stratifie, element thermiquement isolant pourvu d'un tel revetement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES394117A1 (es) * 1970-07-23 1974-03-01 Investigations Scient Pharma Procedimiento de preparacion de principios medicinales ac- tivos.
ES438117A1 (es) * 1974-06-03 1977-01-16 Gen Electric Dispositivo protector electrostatico para aparatos inducti- vos electricos.
ES8500622A1 (es) * 1983-07-11 1984-11-01 Euromed S A Procedimiento para la obtencion de extractos farmacologicamente activos de la planta de genero pygeum africanum
JPS60215608A (ja) * 1984-04-11 1985-10-29 Shiseido Co Ltd 養毛料
EP0287000A1 (en) * 1987-04-17 1988-10-19 Consiglio Nazionale Delle Ricerche Pharmaceutical compositions containing higher alcohols for the treatment of prostatic pathologies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Base de datos JAPIO, 85-215608, 1985 Japan Patent Information Organization (JAPIO) & JP-A-60215608 (SHISEIDO CO LTD), 29-Octubre-85 *

Also Published As

Publication number Publication date
ES2034888B1 (es) 1994-02-16
JPH05194250A (ja) 1993-08-03
US5284873A (en) 1994-02-08
EP0527101A1 (en) 1993-02-10

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