ES2036169T3 - Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilicos, procedimientos para su obtencion asi como agentes antibacterianos que les contienen. - Google Patents

Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilicos, procedimientos para su obtencion asi como agentes antibacterianos que les contienen.

Info

Publication number
ES2036169T3
ES2036169T3 ES198686115955T ES86115955T ES2036169T3 ES 2036169 T3 ES2036169 T3 ES 2036169T3 ES 198686115955 T ES198686115955 T ES 198686115955T ES 86115955 T ES86115955 T ES 86115955T ES 2036169 T3 ES2036169 T3 ES 2036169T3
Authority
ES
Spain
Prior art keywords
oxo
optionally substituted
quinolincarboxilicos
ciclopropil
piperazinil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686115955T
Other languages
English (en)
Inventor
Uwe Dr. Petersen
Klaus Dr. Grohe
Hans-Joachim Dr. Zeiler
Karl Georg Dr. Metzger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2036169T3 publication Critical patent/ES2036169T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS ACIDOS 1-CICLOPROPIL-6-FLUOR-1,4-DIHIDRO-4-OXO-7-(1-PIPERAZINIL)-3QUINOLEINICOS SUSTITUIDOS EN LA PARTE PIPERAZINICA. TAMBIEN SE INDICAN PROCEDIMIENTOS PARA SU OBTENCION ASI COMO LOS AGENTES ANTIBACTERIANOS QUE LOS CONTIENEN.
ES198686115955T 1985-11-28 1986-11-18 Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilicos, procedimientos para su obtencion asi como agentes antibacterianos que les contienen. Expired - Lifetime ES2036169T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853542002 DE3542002A1 (de) 1985-11-28 1985-11-28 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (1)

Publication Number Publication Date
ES2036169T3 true ES2036169T3 (es) 1993-05-16

Family

ID=6287036

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686115955T Expired - Lifetime ES2036169T3 (es) 1985-11-28 1986-11-18 Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilicos, procedimientos para su obtencion asi como agentes antibacterianos que les contienen.

Country Status (6)

Country Link
US (1) US4806539A (es)
EP (1) EP0224178B1 (es)
JP (1) JPS62129273A (es)
AT (1) ATE55125T1 (es)
DE (2) DE3542002A1 (es)
ES (1) ES2036169T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
JPH0751579B2 (ja) * 1987-11-07 1995-06-05 日本新薬株式会社 キノリンカルボン酸誘導体
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
IT1244696B (it) * 1991-02-01 1994-08-08 La Fa Re Srl Derivato chinolonico ad attivita' antibatterica e mucolitica
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
SI2121636T1 (sl) * 2006-12-14 2017-06-30 Janssen Pharmaceutica N.V. Postopek za pripravo derivatov piperazinila in diazepanil benzamida
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5533453A (en) * 1978-08-31 1980-03-08 Dainippon Pharmaceut Co Ltd Preventive and remedy for infectious disease of fish
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS56128765A (en) * 1980-03-14 1981-10-08 Kyorin Pharmaceut Co Ltd Preparation of quinolonecarboxylic acid derivative
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
JPS57203067A (en) * 1981-06-10 1982-12-13 Kanebo Ltd Novel quinolinecarboxylic acid derivatives, their preparations, and antibacterial agent comprising them as active ingredient
DE3248505A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3308909A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel auf chinoloncarbonsaeure-basis
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren

Also Published As

Publication number Publication date
EP0224178B1 (de) 1990-08-01
ATE55125T1 (de) 1990-08-15
JPS62129273A (ja) 1987-06-11
EP0224178A1 (de) 1987-06-03
US4806539A (en) 1989-02-21
DE3673133D1 (de) 1990-09-06
DE3542002A1 (de) 1987-06-04

Similar Documents

Publication Publication Date Title
ES2036169T3 (es) Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(1-piperazinil)-3-quinolincarboxilicos, procedimientos para su obtencion asi como agentes antibacterianos que les contienen.
KR870008847A (ko) 퀴놀론 카복실산 유도체 및 그의 제조방법
DK249685A (da) 7-(3-aryl-1-piperazinyl)- samt 7-(3-cyclohexyl-1-piperazinyl)-3-quinoloncarboxylsyrer, fremgangsmaade til fremstilling deraf samt antibakterielle midler og fodertilsaetningsstoffer indeholdende disse forbindelser
IL70539A0 (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them
KR850002481A (ko) 6-플루오로-1,4-디히드로-4-옥소-7-치환피페라지닐키놀린-3-카르복실산 유도체 및 그 조법
KR860001070A (ko) 할로겐화 퀴놀론 카복실산의 제조방법
ES521086A0 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
ES528496A0 (es) Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(4-(oxoalquil)-1-piperazinil)-3-quinolincarboxilico y sus derivados
GB2014137A (en) Optically-active substituted acetic acid derivatives
KR890006616A (ko) 아제티디닐 퀴놀론 카복실산 및 에스테르
ZA855156B (en) Novel ether-oxides derived from cyclopropylphenols
KR890009403A (ko) 동결 건조 주사제
DK35387D0 (da) Quinolinderivater og fremgangsmaade til fremstilling deraf samt midler indeholdende derivaterne
KR870003120A (ko) 퀴놀린유도체의 제조방법
FI851090L (fi) Foerfarande foer framstaellning av kinolinkarboxylsyraderivat.
ES387617A1 (es) Procedimiento para la preparacion de nuevos estabilizadorescontra la luz ultravioleta.
DK161090A (da) Nyt topikalt praeparat til behandling af alopeci
GB1079258A (en) 19-nor-progesterone derivatives
KR890003741A (ko) 7-(1-피롤리디닐)퀴놀론카르복실산 유도체
KR830000248A (ko) 세파로스포린 항생물질의 제조방법
KR890006589A (ko) 7-아미노-1-사이클로프로필-8-클로로-6-플루오로-1,4-디하이드로-4-옥소-3-퀴놀린 카복실산, 이의 제조방법 및 이 화합물을 함유하는 항균제

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 224178

Country of ref document: ES