ES2037908T3 - Un procedimiento para la preparacion de una tableta de capas multiples en una forma de dosificacion unitaria solida. - Google Patents

Un procedimiento para la preparacion de una tableta de capas multiples en una forma de dosificacion unitaria solida.

Info

Publication number
ES2037908T3
ES2037908T3 ES198989109925T ES89109925T ES2037908T3 ES 2037908 T3 ES2037908 T3 ES 2037908T3 ES 198989109925 T ES198989109925 T ES 198989109925T ES 89109925 T ES89109925 T ES 89109925T ES 2037908 T3 ES2037908 T3 ES 2037908T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
dosage form
unit dosage
multiple layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198989109925T
Other languages
English (en)
Inventor
Herbert Schock
William R. Nadler
David F. Long
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2037908T3 publication Critical patent/ES2037908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION ES DIRIGIDA A UNA TABLETA MULTILAMINADA QUE CONTIENE UNA LAMINA IBUPROFENO, UNA LAMINA ANTIHISTAMINICA PIPERIDINOALCANOL, Y UNA LAMINA O LAMINAS QUE CONTIENEN EXCIPIENTE FARMACEUTICOS CONVENCIONALES, LA CUAL ES ENTREMEZCLADA ENTRE EL IBUPROFEN Y LA LAMINA PIPERIDINOALCANOL Y SIRVE PARA SEPARARLOS FISICAMENTE. ESTA TABLETA SOLVENTA LOS PROBLEMAS ASOCIADOS CON LAS INCOMPATIBILIDADES FISICAS Y QUIMICAS ENTRE EL IBUPROFENO Y LOS ANTIHISTAMINICOS PIPERIDINOALCANOL.
ES198989109925T 1988-06-01 1989-06-01 Un procedimiento para la preparacion de una tableta de capas multiples en una forma de dosificacion unitaria solida. Expired - Lifetime ES2037908T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20081788A 1988-06-01 1988-06-01
US07/344,183 US4999226A (en) 1988-06-01 1989-04-27 Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination

Publications (1)

Publication Number Publication Date
ES2037908T3 true ES2037908T3 (es) 1993-07-01

Family

ID=26896133

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198989109925T Expired - Lifetime ES2037908T3 (es) 1988-06-01 1989-06-01 Un procedimiento para la preparacion de una tableta de capas multiples en una forma de dosificacion unitaria solida.

Country Status (17)

Country Link
US (1) US4999226A (es)
EP (1) EP0348683B1 (es)
JP (1) JP2757017B2 (es)
KR (1) KR0126129B1 (es)
CN (1) CN1038021A (es)
AU (1) AU615751B2 (es)
CA (1) CA1327011C (es)
DE (1) DE68900378D1 (es)
DK (1) DK174638B1 (es)
ES (1) ES2037908T3 (es)
FI (1) FI90205C (es)
GR (1) GR3003477T3 (es)
HU (1) HU202746B (es)
IE (1) IE61182B1 (es)
IL (1) IL90461A0 (es)
NZ (1) NZ229325A (es)
PT (1) PT90689B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
JPH069382A (ja) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 安定化された固型製剤およびその製造方法
EP0674527A1 (en) * 1992-12-21 1995-10-04 The Procter & Gamble Company Use of s(+) antipodes of analgesic agents for the manufacture of a composition to treat respiratory disorders
ES2107235T3 (es) * 1993-06-14 1997-11-16 Janssen Pharmaceutica Nv Tableta de liberacion prolongada, revestida con pelicula, de astemizol y pseudoefedrina.
ES2153863T3 (es) * 1993-10-25 2001-03-16 Merrell Pharma Inc Composicion farmaceutica estable a base de terfenadina e ibuprofeno.
JP3168582B2 (ja) * 1993-12-10 2001-05-21 藤沢薬品工業株式会社 解熱鎮痛配合剤
US5419917A (en) * 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
US5399356A (en) * 1994-03-24 1995-03-21 The Procter & Gamble Company Process for making solid dose forms containing bismuth
DK0812195T3 (da) * 1995-02-28 2003-03-03 Aventis Pharma Inc Farmaceutisk sammensætning til piperidinoalkanolforbindelser
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6077539A (en) * 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
JP4344405B2 (ja) * 1997-08-26 2009-10-14 アベンティス・ファーマスーティカルズ・インコーポレイテッド ピペリジノアルカノール−鬱血除去剤の組合せ用医薬組成物
MY125516A (en) * 1999-11-16 2006-08-30 Smithkline Beecham Plc Novel composition based on thiazolidinedione and metformin and use
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
AU2002214305A1 (en) * 2000-11-17 2002-05-27 Takeda Chemical Industries Ltd. Pharmaceutical preparation containing copolyvidone
NZ532096A (en) * 2001-09-28 2006-10-27 Mcneil Ppc Inc Dosage forms having an inner core and outer shell with different shapes
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
US7807197B2 (en) * 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
US20050220877A1 (en) * 2004-03-31 2005-10-06 Patel Ashish A Bilayer tablet comprising an antihistamine and a decongestant
AU2005245025B2 (en) * 2004-05-21 2010-06-03 Accu-Break Technologies, Inc. Pharmaceutical tablets comprising two or more unitary segments
CN1960712B (zh) * 2004-05-21 2011-04-20 阿库-伯雷克技术公司 包含多个片段的刻痕药片
US8673352B2 (en) * 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
CA2635313C (en) 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
CA2748728C (en) 2009-01-05 2017-01-03 Mcneil-Ppc, Inc. Tablet containing cetirizine, pseudoephedrine, and naproxen containing a barrier layer
US8252330B2 (en) 2009-01-05 2012-08-28 Mcneil-Ppc, Inc. Tablet containing coated particles of cetirizine, pseudoephedrine, and/or naproxen
US8246988B2 (en) 2009-01-05 2012-08-21 Mcneil-Ppc, Inc. Three layer tablet containing cetirizine, pseudoephedrine, and naproxen
US20130115250A1 (en) * 2009-05-13 2013-05-09 Wyeth Llc Burst Drug Release Compositions
CN110022862B (zh) * 2016-12-09 2022-05-24 拜耳动物保健有限责任公司 药物制剂及其制造方法
CN108703828B (zh) * 2018-06-04 2021-03-30 王荣涛 下肢牵引器
CN109481272B (zh) * 2019-01-10 2020-07-24 河南省洛阳正骨医院（河南省骨科医院） 肺癌骨转移术后康复装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70071A (en) * 1982-11-01 1987-12-31 Merrell Dow Pharma Multilayered sustained release pharmaceutical tablets having non-uniform distribution of active ingredient
US4882167A (en) * 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4783465A (en) * 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4552899A (en) * 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4806359A (en) * 1987-04-22 1989-02-21 Mcneilab, Inc. Iburprofen sustained release matrix and process
US4808413A (en) * 1987-04-28 1989-02-28 E. R. Squibb & Sons, Inc. Pharmaceutical compositions in the form of beadlets and method

Also Published As

Publication number Publication date
AU3580089A (en) 1989-12-07
AU615751B2 (en) 1991-10-10
JP2757017B2 (ja) 1998-05-25
IE891795L (en) 1989-12-01
FI90205C (fi) 1994-01-10
GR3003477T3 (en) 1993-02-17
HUT52367A (en) 1990-07-28
FI90205B (fi) 1993-09-30
FI892640A0 (fi) 1989-05-31
HU202746B (en) 1991-04-29
DK265489A (da) 1989-12-02
CN1038021A (zh) 1989-12-20
EP0348683A1 (en) 1990-01-03
PT90689A (pt) 1989-12-29
KR900017573A (ko) 1990-12-19
DK174638B1 (da) 2003-08-04
PT90689B (pt) 1993-12-31
FI892640L (fi) 1989-12-02
KR0126129B1 (ko) 1997-12-24
IL90461A0 (en) 1990-01-18
DE68900378D1 (de) 1991-12-05
IE61182B1 (en) 1994-10-05
NZ229325A (en) 1990-10-26
JPH0228111A (ja) 1990-01-30
EP0348683B1 (en) 1991-10-30
CA1327011C (en) 1994-02-15
DK265489D0 (da) 1989-05-31
US4999226A (en) 1991-03-12

Similar Documents

Publication Publication Date Title
ES2037908T3 (es) Un procedimiento para la preparacion de una tableta de capas multiples en una forma de dosificacion unitaria solida.
ES2008580A6 (es) Forma de dosificacion para la liberacion rapida y lenta de agente beneficioso.
ES2110633T3 (es) Composicion estable de dosificacion oral de liberacion prolongada.
ES2060825T3 (es) Un sistema terapeutico para el administracion retardada y controlada de sustancias activas por via percutanea o a traves de la mucosa.
MX9203557A (es) Una forma de dosis para suministrar el farmaco benefico verapamil.
AR033423A1 (es) Sales farmaceuticas constituidas de una sustancia activa farmaceutica y al menos un edulcorante, medicamentos que contienen estas sales y uso de estas sales para la preparacion de medicamentos
ES2096080T3 (es) Formas de presentacion de un medicamento conteniendo pantoprazol y administrado por via oral.
AR242711A1 (es) Pelicula laminada bicomponente, el proceso para obtenerla y el articulo absorbente desechable que la incluye.
ES2176436T3 (es) Nueva forma de dosificacion farmaceutica oral.
ES2064451T3 (es) Compresa sanitaria integral.
IT8719064A0 (it) Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive.
ES2181962T3 (es) Panel de soporte para asegurar miembros de formacion de pared externa.
ES2117146T3 (es) Tableta farmaceutica capaz de liberar una o varias sustancias medicamentosas a diferentes velocidades.
ES2107235T3 (es) Tableta de liberacion prolongada, revestida con pelicula, de astemizol y pseudoefedrina.
AR026968A1 (es) Una tableta matriz que permite la liberacion prolongada de trimetazidina lluego de su administracion por via oral
CO4770978A1 (es) Empleo de epinastina para el tratamiento de dolores
PE20030580A1 (es) Composiciones farmaceuticas de glibenclamida y metformina, en capas separadas
UY25791A1 (es) Combinaciones para la diabetes
AR013052A1 (es) Una forma de dosis oral solida que comprende una combinacion de metformin y glibenclamida
ES2530769T3 (es) Métodos para la activación de células T in vivo por células dendríticas pulsadas con antígeno
ES2135458T3 (es) Sistema de medicamento que comprende una matriz de gel que contiene un farmaco inmobilizado.
NO992944L (no) Virkestoffbµrer for avgivelse av apomorfin i munnhulen
AR043070A1 (es) Sistema monolitico que contiene una o mas drogas, formado por tres capas con diferentes mecanismos de liberacion
MX169815B (es) Tableta de medicamento masticable que contiene medios para enmascarar el sabor
CO5011082A1 (es) Formulacion medicamentosa con liberacion controlada de sus- tancia activa

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 348683

Country of ref document: ES