ES2039313T3 - Nuevos derivados de mediadores endogenos, sus sales, procedimiento de preparacion, aplicaciones, y composiciones que los contienen. - Google Patents

Nuevos derivados de mediadores endogenos, sus sales, procedimiento de preparacion, aplicaciones, y composiciones que los contienen.

Info

Publication number
ES2039313T3
ES2039313T3 ES91430009T ES91430009T ES2039313T3 ES 2039313 T3 ES2039313 T3 ES 2039313T3 ES 91430009 T ES91430009 T ES 91430009T ES 91430009 T ES91430009 T ES 91430009T ES 2039313 T3 ES2039313 T3 ES 2039313T3
Authority
ES
Spain
Prior art keywords
sub
mineral
carbon atoms
well
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91430009T
Other languages
English (en)
Other versions
ES2039313T1 (es
Inventor
Jacques Chauveau
Michel Delaage
Anne Morel
Louis Segu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMMUNOTECH SA
Original Assignee
IMMUNOTECH SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9006292A external-priority patent/FR2662082B1/fr
Priority claimed from FR9101292A external-priority patent/FR2671971B1/fr
Application filed by IMMUNOTECH SA filed Critical IMMUNOTECH SA
Publication of ES2039313T1 publication Critical patent/ES2039313T1/es
Application granted granted Critical
Publication of ES2039313T3 publication Critical patent/ES2039313T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

DERIVADOS DE MOLECULAS BIOLOGICAMENTE ACTIVAS QUE COMPRENDE UNA FUNCION AMINA PRIMARIA Y UN NUCLEO HIDROXILADO ASI COMO SUS SALES DE ADICION CON LOS ACIDOS MINERALES U ORGANICOS, CARACTERIZADOS EN QUE RESPONDEN A LA FORMULA I: [R''R"N-A-B-O-CH SUB 2-CO] SUB NR SUB 1 (1) N REPRESENTA UN NUMERO ENTERO DE 1 A 10; A REPRESENTA UNA CADENA ALQUILENA LINEAL O RAMIFICADA QUE CONTIENE DE 6 A 10 ATOMOS DE CARBONO, PUDIENDO SER SUSTITUIDOS Y EVENTUALMENTE UN HETEROATOMO, O UN GRUPO -B SUB 1-X-B SUB 2-, EN EL QUE B SUB 1 Y B SUB 2 REPRESENTA EL B ANTES CITADO Y X REPRESENTA UN ATOMO DE OXIGENO O UN ATOMO DE OXIGENO O UNA CADENA ALQUILENA QUE CONTIENE DE 1 A 4 ATOMOS DE CARBONO, -R SUB 1 REPRESENTA UN RESTO AMINADO O UN RESTO DE UN ALCOHOL, Y -R'' Y R" REPRESENTAN UN RADICAL ALQUILO QUE CONTIENE DE 1 A 5 ATOMOS DE CARBONO, UN ATOMO DE HIDROGENO O UN RADICAL HIDROFOBO, ASI COMO SUS SALES DE ADICION CON LOS ACIDOS MINERALES U ORGANICOS, ENTENDIENDO QUE R'' Y R" NO PUEDEN REPRESENTAR UN DERIVADO DE 2-HIDROXI-3-FENOXIPROPILO O DE 2-HIDROXI-2-FENILETILO, ASI COMO SUS SALES DE ADICION CON LOS ACIDOS MINERALES U ORGANICOS; PROCESO DE PREPARACION Y APLICACIONES, EN PARTICULAR A LA FORMACION DE IMAGENES, A LA PURIFICACION, A LA PREPARACION DE ANTICUERPOS, A LA DOSIFICACION DE LA HORMONA TOTAL Y COMO MEDICAMENTOS, COMPOSICIONES QUE LOS CONTIENEN Y EQUIPO DE ANALISIS.
ES91430009T 1990-05-15 1991-05-13 Nuevos derivados de mediadores endogenos, sus sales, procedimiento de preparacion, aplicaciones, y composiciones que los contienen. Expired - Lifetime ES2039313T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9006292A FR2662082B1 (fr) 1990-05-15 1990-05-15 Nouveaux derives de mediateurs endogenes, leurs sels, procede de preparation et applications.
FR9101292A FR2671971B1 (fr) 1991-01-30 1991-01-30 Nouveaux derives de la serotonine, application a titre de medicament et compositions les renfermant.

Publications (2)

Publication Number Publication Date
ES2039313T1 ES2039313T1 (es) 1993-10-01
ES2039313T3 true ES2039313T3 (es) 1995-04-16

Family

ID=26228029

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91430009T Expired - Lifetime ES2039313T3 (es) 1990-05-15 1991-05-13 Nuevos derivados de mediadores endogenos, sus sales, procedimiento de preparacion, aplicaciones, y composiciones que los contienen.

Country Status (12)

Country Link
US (1) US5298491A (es)
EP (1) EP0457701B1 (es)
JP (1) JP2968623B2 (es)
KR (1) KR0138750B1 (es)
AT (1) ATE118758T1 (es)
AU (1) AU650265B2 (es)
CA (1) CA2042295A1 (es)
DE (1) DE69107512T2 (es)
DK (1) DK0457701T3 (es)
ES (1) ES2039313T3 (es)
IE (1) IE67888B1 (es)
NO (1) NO308663B1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW288010B (es) * 1992-03-05 1996-10-11 Pfizer
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
TW251284B (es) * 1992-11-02 1995-07-11 Pfizer
FR2699918B1 (fr) * 1992-12-30 1995-03-17 Pf Medicament Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments.
DK0703923T3 (da) * 1993-06-18 1999-06-21 Nycomed Imaging As Faktor VII afledte peptider
AU729415B2 (en) 1996-07-12 2001-02-01 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
FR2773489B1 (fr) * 1998-01-15 2001-03-23 Immunotech Sa Nouvelle composition destinee a la voie oromuqueuse notamment pernasale
KR100596641B1 (ko) * 1998-12-11 2006-10-04 이승진 진단용 공중합성 미셀 및 그의 제조방법
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
DK1523486T3 (da) 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet
DE60329607D1 (de) 2002-06-21 2009-11-19 Suven Life Sciences Ltd Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
JP4559230B2 (ja) * 2002-11-28 2010-10-06 スベン ライフ サイエンシズ リミティド セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物
MXPA05005700A (es) 2002-11-28 2005-08-16 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxiindoles.
EA009367B1 (ru) 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703325A (en) * 1951-12-06 1955-03-01 Upjohn Co Preparation of 5-benzyloxytryptamines
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3686213A (en) * 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
US4046636A (en) * 1974-06-20 1977-09-06 Syva Company Diazepam enzyme conjugates
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
US4040907A (en) * 1974-06-20 1977-08-09 Syva Company Iodothyronine enzyme conjugates
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
US4426453A (en) * 1980-09-18 1984-01-17 Amersham International Limited Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds
EP0099707B1 (en) * 1982-07-16 1986-12-10 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS60132935A (ja) * 1983-12-20 1985-07-16 Sumitomo Chem Co Ltd フエニルセリン誘導体及びその製造方法
FR2562671B1 (fr) * 1984-04-10 1986-07-25 Immunotech Sa Procede pour le dosage immunologique des monoamines
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
DE3628795A1 (de) * 1986-08-25 1988-03-03 Hoechst Ag Neue thyroninderivate
US5019586A (en) * 1987-04-14 1991-05-28 Glaxo Group Limited Ketone derivatives
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
GB8802127D0 (en) * 1988-02-01 1988-03-02 Glaxo Group Ltd Chemical compounds
US4933324A (en) * 1988-02-26 1990-06-12 Shashoua Victor E Fatty acid-neuroactive drug conjugate as a prodrug
FR2671971B1 (fr) * 1991-01-30 1994-01-28 Immunotech Nouveaux derives de la serotonine, application a titre de medicament et compositions les renfermant.
FR2662082B1 (fr) * 1990-05-15 1994-12-23 Immunotech Sa Nouveaux derives de mediateurs endogenes, leurs sels, procede de preparation et applications.

Also Published As

Publication number Publication date
AU650265B2 (en) 1994-06-16
KR910020034A (ko) 1991-12-19
JP2968623B2 (ja) 1999-10-25
JPH04288044A (ja) 1992-10-13
IE67888B1 (en) 1996-05-01
KR0138750B1 (ko) 1998-05-01
DE69107512D1 (de) 1995-03-30
NO308663B1 (no) 2000-10-09
CA2042295A1 (fr) 1991-11-16
IE911649A1 (en) 1991-11-20
NO911880L (no) 1991-11-18
US5298491A (en) 1994-03-29
EP0457701A1 (fr) 1991-11-21
DE69107512T2 (de) 1995-06-29
ES2039313T1 (es) 1993-10-01
EP0457701B1 (fr) 1995-02-22
ATE118758T1 (de) 1995-03-15
AU7704591A (en) 1991-11-21
NO911880D0 (no) 1991-05-14
DK0457701T3 (da) 1996-02-05

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