ES2039360T3 - Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos. - Google Patents

Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos.

Info

Publication number
ES2039360T3
ES2039360T3 ES198686730154T ES86730154T ES2039360T3 ES 2039360 T3 ES2039360 T3 ES 2039360T3 ES 198686730154 T ES198686730154 T ES 198686730154T ES 86730154 T ES86730154 T ES 86730154T ES 2039360 T3 ES2039360 T3 ES 2039360T3
Authority
ES
Spain
Prior art keywords
group
beta
figxx
cycloalkyl
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686730154T
Other languages
English (en)
Inventor
Helmut Dr. Biere
Mogens Engelstoft
Andreas Dr. Huth
Dieter Dr. Rahtz
Ralph Dr. Schmiechen
Dieter Dr. Seidelmann
David Norman Dr. Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2039360T3 publication Critical patent/ES2039360T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Eyeglasses (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE 5, 6, 7, 8 TETRAHIDRO-BETA-CARBOLINA DE FORMULA GENERAL FIGXX EN LA QUE R1 ES UN GRUPO OXIDIAZOLILO DE FORMULA FIGXX EN LA QUE R2 REPRESENTA H, UN GRUPO ALQUILO O CICLOALQUILO INFERIOR, Y UN GRUPO COOR3 EN EL QUE R3 REPRESENTA UN H O UN GRUPO ALQUILO INFERIOR Y UN GRUPO CONR4R5 EN EL QUE R4 Y R5 REPRESENTAN H, O BIEN UN GRUPO ALQUILO O HIDROXIALQUILO INFERIOR, NO PUDIENDO SER AMBOS A LA VEZ H, O BIEN, R4 Y R5 FORMAN CON EL ATOMO DE NITROGENO VECINO UN ANILLO DE 5 O 6 ATOMOS QUE PUEDE CONTENER ADEMAS UN HETEROATOMO, Y RA REPRESENTA H,=0, CICLOALQUILO, -COOR3, EN EL QUE R3 REPRESENTA LO INDICADO ANTERIORMENTE, O BIEN, UN GRUPO ALQUILO INFERIOR QUE PUEDE ESTAR SUSTITUIDO CON OH, HALOGENOS, GRUPOS ALCOXI, FENILO Y FENOXI INFERIORES, O BIEN, _NR4R5 EN EL QUE R4 Y R5 REPRESENTAN LO INDICADO ANTERIORMENTE. RB PUEDE SER H, O UN GRUPO ALQUILO O ALCOXIALQUILO INFERIOR. ESTOS COMPUESTOS PRESENTAN VALIOSAS PROPIEDADES FARMACEUTICAS.
ES198686730154T 1985-10-04 1986-10-03 Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos. Expired - Lifetime ES2039360T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853535928 DE3535928A1 (de) 1985-10-04 1985-10-04 Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2039360T3 true ES2039360T3 (es) 1993-10-01

Family

ID=6283083

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686730154T Expired - Lifetime ES2039360T3 (es) 1985-10-04 1986-10-03 Tetrahidro-beta-carbolinas, procedimiento para su preparacion y su utilizacion como medicamentos.

Country Status (16)

Country Link
US (1) US4855295A (es)
EP (1) EP0217737B1 (es)
JP (1) JPH0759580B2 (es)
AT (1) ATE66226T1 (es)
AU (1) AU593024B2 (es)
CA (1) CA1269981A (es)
DE (2) DE3535928A1 (es)
DK (1) DK169581B1 (es)
ES (1) ES2039360T3 (es)
FI (1) FI864018A7 (es)
GR (1) GR3002944T3 (es)
HU (1) HU195814B (es)
IE (1) IE58896B1 (es)
IL (1) IL80215A0 (es)
NO (1) NO164354C (es)
ZA (1) ZA867616B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06502147A (ja) * 1990-10-09 1994-03-10 ニューロゲン　コーポレイション 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド
FR2677024B1 (fr) * 1991-05-29 1995-03-03 Centre Nat Rech Scient Composes derives des aza-6-indoles, ligands du recepteur des benzodiazepines et medicaments les contenant.
US5367077A (en) * 1992-04-08 1994-11-22 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
AU664912B2 (en) * 1992-09-02 1995-12-07 Dainippon Pharmaceutical Co. Ltd. Novel 3-oxadiazolyl-1,6-naphthyridine derivatives
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
CA2140722A1 (en) * 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US5550118A (en) * 1994-01-31 1996-08-27 Eli Lilly And Company Polyhydronorharman synthase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DE3240513A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung
DK149270C (da) * 1983-05-27 1986-08-25 Schering Ag Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives

Also Published As

Publication number Publication date
EP0217737A3 (en) 1988-06-01
US4855295A (en) 1989-08-08
ZA867616B (en) 1987-05-27
DE3535928A1 (de) 1987-04-09
NO863962D0 (no) 1986-10-03
IL80215A0 (en) 1987-01-30
DE3680850D1 (de) 1991-09-19
NO863962L (no) 1987-04-06
ATE66226T1 (de) 1991-08-15
IE58896B1 (en) 1993-12-01
DK169581B1 (da) 1994-12-12
NO164354B (no) 1990-06-18
JPS62181278A (ja) 1987-08-08
DK471686A (da) 1987-04-05
AU593024B2 (en) 1990-02-01
HU195814B (en) 1988-07-28
FI864018A7 (fi) 1987-04-05
CA1269981A (en) 1990-06-05
FI864018A0 (fi) 1986-10-03
EP0217737A2 (de) 1987-04-08
NO164354C (no) 1990-09-26
JPH0759580B2 (ja) 1995-06-28
IE862629L (en) 1987-04-04
GR3002944T3 (en) 1993-01-25
HUT42091A (en) 1987-06-29
EP0217737B1 (de) 1991-08-14
AU6366286A (en) 1987-04-09
DK471686D0 (da) 1986-10-02

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