ES2039617T3 - Procedimiento de preparacion de imidas policiclicas psicotropicas. - Google Patents

Procedimiento de preparacion de imidas policiclicas psicotropicas.

Info

Publication number
ES2039617T3
ES2039617T3 ES198888302499T ES88302499T ES2039617T3 ES 2039617 T3 ES2039617 T3 ES 2039617T3 ES 198888302499 T ES198888302499 T ES 198888302499T ES 88302499 T ES88302499 T ES 88302499T ES 2039617 T3 ES2039617 T3 ES 2039617T3
Authority
ES
Spain
Prior art keywords
carbon atoms
metheno
chem
taken together
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302499T
Other languages
English (en)
Inventor
Gary Paul Stack
Thomas David Golobish
Magid Abdel-Megid Abou-Gharbia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2039617T3 publication Critical patent/ES2039617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LAS AMIDAS SUSTITUIDAS DE FORMULA (I) DONDE X, R, R1 Y R2 REPRESENTAN SUSTANCIAS CUYA FORMULA SE DESCRIBE SON AGENTES ANTOPSICOTICOS Y ANSIOLITICOS CON MUY PEQUEÑOS EFECTOS SECUNDARIOS EXTRAPIRAMIDALES.
ES198888302499T 1987-04-03 1988-03-22 Procedimiento de preparacion de imidas policiclicas psicotropicas. Expired - Lifetime ES2039617T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/034,820 US4797488A (en) 1987-04-03 1987-04-03 Psychotropic polycyclic imides

Publications (1)

Publication Number Publication Date
ES2039617T3 true ES2039617T3 (es) 1993-10-01

Family

ID=21878820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302499T Expired - Lifetime ES2039617T3 (es) 1987-04-03 1988-03-22 Procedimiento de preparacion de imidas policiclicas psicotropicas.

Country Status (14)

Country Link
US (1) US4797488A (es)
EP (1) EP0286263B1 (es)
JP (1) JPH01502756A (es)
KR (1) KR960001478B1 (es)
AT (1) ATE63551T1 (es)
AU (2) AU597480B2 (es)
CA (1) CA1306251C (es)
DE (1) DE3862793D1 (es)
ES (1) ES2039617T3 (es)
GB (1) GB2203428B (es)
GR (1) GR3001959T3 (es)
IE (1) IE61957B1 (es)
PT (1) PT87122B (es)
WO (1) WO1988007529A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US4994455A (en) * 1987-10-26 1991-02-19 Pfizer Inc. Anti-anxiety agents
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US4957913A (en) * 1989-11-22 1990-09-18 American Home Products Corp. Antihypertensive polycyclic imides
US5053508A (en) * 1990-03-09 1991-10-01 American Home Products Corporation Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
US5219983A (en) * 1991-05-08 1993-06-15 Phillips Petroleum Company Preparation of poly (biphenylene/phenylene) sulfide
US5134141A (en) * 1991-09-06 1992-07-28 American Home Products Corporation Antidepressant polycyclic imides to treat depression
US5183819A (en) * 1992-05-11 1993-02-02 American Home Products Corporation Use of fused bicyclic imides in the treatment of various CNS disorders
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5670696A (en) * 1994-09-02 1997-09-23 Arakawa Chemical Industires Ltd. Alicyclic bifunctional compounds and processes for their preparation
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
EP1495000A4 (en) * 2002-04-08 2005-10-05 Ranbaxy Lab Ltd ALPHA, OMEGA DICARBOXIMID DERIVATIVES SUITED AS UROSELECTIVE A1A ADRENEOCEPTOR BLOCKERS
US20060247249A1 (en) * 2005-11-16 2006-11-02 Mohammad Salman Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers
CN102223945A (zh) 2008-11-26 2011-10-19 东丽东燃机能膜合同会社 微孔膜、该微孔膜的制备方法以及该微孔膜作为电池隔膜的应用
CN102153567B (zh) * 2010-05-28 2013-08-14 重庆天地药业有限责任公司 一种制备头孢西丁酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
JPS6087284A (ja) * 1983-10-19 1985-05-16 Sumitomo Chem Co Ltd コハク酸イミド誘導体及びその酸付加塩
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
CA1286672C (en) * 1985-10-16 1991-07-23 Magid A. Abou-Gharbia Fused bicyclic imides with psychotropic activity
US4675403A (en) * 1985-10-16 1987-06-23 American Home Products Corporation 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
US4732983A (en) * 1987-04-03 1988-03-22 American Home Products Corporation Pyschotropic polycyclic imides
US4994455A (en) * 1987-10-26 1991-02-19 Pfizer Inc. Anti-anxiety agents

Also Published As

Publication number Publication date
ATE63551T1 (de) 1991-06-15
CA1306251C (en) 1992-08-11
AU5115890A (en) 1990-06-28
EP0286263A1 (en) 1988-10-12
PT87122B (pt) 1992-07-31
AU1351288A (en) 1988-10-06
AU617930B2 (en) 1991-12-05
PT87122A (pt) 1988-04-01
DE3862793D1 (en) 1991-06-20
KR960001478B1 (ko) 1996-01-31
IE61957B1 (en) 1994-11-30
GB2203428A (en) 1988-10-19
AU597480B2 (en) 1990-05-31
GR3001959T3 (en) 1992-11-23
EP0286263B1 (en) 1991-05-15
GB2203428B (en) 1990-10-31
KR890700592A (ko) 1989-04-26
WO1988007529A1 (en) 1988-10-06
GB8806778D0 (en) 1988-04-20
US4797488A (en) 1989-01-10
IE880963L (en) 1988-10-03
JPH01502756A (ja) 1989-09-21

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