ES2041785T3 - Un procedimiento para preparar nuevos derivados de prostaglandinas. - Google Patents
Un procedimiento para preparar nuevos derivados de prostaglandinas.Info
- Publication number
- ES2041785T3 ES2041785T3 ES198888300415T ES88300415T ES2041785T3 ES 2041785 T3 ES2041785 T3 ES 2041785T3 ES 198888300415 T ES198888300415 T ES 198888300415T ES 88300415 T ES88300415 T ES 88300415T ES 2041785 T3 ES2041785 T3 ES 2041785T3
- Authority
- ES
- Spain
- Prior art keywords
- prostaglandinas
- procedure
- side chain
- new derivatives
- preparing new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
DERIVADOS DE PROSTAGLANDINAS QUE TIENEN UN GRUPO OXO EN POSICIONES ESPECIFICAS EN LA CADENA LATERAL (ALFA) Y QUE TIENEN LA FORMULA (I), EN LA QUE R1-R5 REPRESENTAN HIDROGENO O VARIOS GRUPOS ORGANICOS, M ES 0-5 Y N ES 2-5, TIENEN UNA SERIE DE EFECTOS FISIOLOGICOS, EN PARTICULAR UNA FUERTE ACTIVIDAD ANTIULCEROSA, ACOMPAÑADA DE UNA LIMITADA CAPACIDAD PARA INHIBIR LA AGREGACION DE LAMINILLAS SANGUINEAS. SE PUEDEN OBTENER POR OXIDACION DEL CORRESPONDIENTE COMPUESTO EN EL QUE EL GRUPO OXO DEL ANILLO DE CICLOPENTANO, Y OPCIONALMENTE DE LA CADENA LATERAL (ALFA), SE SUSTITUYE POR UN GRUPO HIDROXI.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP940687 | 1987-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2041785T3 true ES2041785T3 (es) | 1993-12-01 |
Family
ID=11719530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198888300415T Expired - Lifetime ES2041785T3 (es) | 1987-01-19 | 1988-01-19 | Un procedimiento para preparar nuevos derivados de prostaglandinas. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4981872A (es) |
| EP (1) | EP0276124B1 (es) |
| KR (1) | KR930006200B1 (es) |
| AT (1) | ATE76402T1 (es) |
| CA (1) | CA1326021C (es) |
| DE (1) | DE3871160D1 (es) |
| ES (1) | ES2041785T3 (es) |
| GR (1) | GR3005153T3 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU511711B2 (en) * | 1976-12-30 | 1980-09-04 | Upjohn Company, The | 6-Oxo and 5, 6-Dihalo prostaglandin analogues |
| US4202822A (en) * | 1977-12-08 | 1980-05-13 | American Cyanamid Company | 1-Hydroxymethyl-1-oxo-prostane derivatives of the F1 series |
| US4338252A (en) * | 1979-09-27 | 1982-07-06 | American Cyanamid Company | 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins |
| JPS6033430B2 (ja) * | 1980-05-12 | 1985-08-02 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| JPH07116134B2 (ja) * | 1987-01-08 | 1995-12-13 | 帝人株式会社 | ５−オキソプロスタグランジンｅ▲下１▼類及びその製法 |
-
1988
- 1988-01-15 US US07/144,878 patent/US4981872A/en not_active Expired - Fee Related
- 1988-01-19 ES ES198888300415T patent/ES2041785T3/es not_active Expired - Lifetime
- 1988-01-19 EP EP88300415A patent/EP0276124B1/en not_active Expired - Lifetime
- 1988-01-19 AT AT88300415T patent/ATE76402T1/de not_active IP Right Cessation
- 1988-01-19 CA CA000556820A patent/CA1326021C/en not_active Expired - Fee Related
- 1988-01-19 DE DE8888300415T patent/DE3871160D1/de not_active Expired - Fee Related
- 1988-01-19 KR KR1019880000372A patent/KR930006200B1/ko not_active Expired - Fee Related
-
1992
- 1992-07-13 GR GR920401498T patent/GR3005153T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0276124A3 (en) | 1989-02-01 |
| DE3871160D1 (de) | 1992-06-25 |
| CA1326021C (en) | 1994-01-11 |
| KR880008984A (ko) | 1988-09-13 |
| EP0276124B1 (en) | 1992-05-20 |
| KR930006200B1 (ko) | 1993-07-08 |
| GR3005153T3 (es) | 1993-05-24 |
| US4981872A (en) | 1991-01-01 |
| ATE76402T1 (de) | 1992-06-15 |
| EP0276124A2 (en) | 1988-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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