ES2042061T3 - Procedimiento para la obtencion de derivados carbamoilados del acido hidroxamico. - Google Patents
Procedimiento para la obtencion de derivados carbamoilados del acido hidroxamico.Info
- Publication number
- ES2042061T3 ES2042061T3 ES198989810405T ES89810405T ES2042061T3 ES 2042061 T3 ES2042061 T3 ES 2042061T3 ES 198989810405 T ES198989810405 T ES 198989810405T ES 89810405 T ES89810405 T ES 89810405T ES 2042061 T3 ES2042061 T3 ES 2042061T3
- Authority
- ES
- Spain
- Prior art keywords
- iii
- formula
- iron
- carbamoyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- -1 C1-C4-alkanoyloxy Chemical group 0.000 abstract 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical compound O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical class CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001398 aluminium Chemical class 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 229960000958 deferoxamine Drugs 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
SE DESCRIBEN DERIVADOS DE O - CARBAMOILO DE DESFERRIOXAMINA B DE LA FORMULA(I), DONDE LOS SIMBOLOS A1, A2, A3, AC, B TIENEN LOS SIGNIFICADOS DADOS EN LA DESCRIPCION. ESTOS COMPUESTOS FORMAN FUERTES COMPLEJOS FE(III) Y AL EN LAS CELULAS VIVAS. SON PARA EL TRATAMIENTO DE SUSTANCIAS QUE PRODUCEN ENFERMEDADES EN SAGRE CALIENTE, LAS CUALES POR UNA SOBRE EDULCORACION FORMA UNA FE(III) O UN AL CON CUERPOS QUE CUELGAN JUNTO O POR FE(III) INDEPENDIEN TE DE LOS ORGANISMOS PATOGENOS. LOS COMPUESTOS DE LA FORMULA(I) SE OBTIENEN P.E. POR TRANSFORMACIONCONVENCIONAL DE DESFERRIOXAMINA B N - SUSTITUIDO CON UN ESTER ACIDO ISOCIANOTOALCANO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH218188 | 1988-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2042061T3 true ES2042061T3 (es) | 1993-12-01 |
Family
ID=4227782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198989810405T Expired - Lifetime ES2042061T3 (es) | 1988-06-08 | 1989-05-30 | Procedimiento para la obtencion de derivados carbamoilados del acido hidroxamico. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0346281B1 (es) |
| JP (1) | JPH0242052A (es) |
| AT (1) | ATE77368T1 (es) |
| DE (1) | DE58901673D1 (es) |
| DK (1) | DK278689A (es) |
| ES (1) | ES2042061T3 (es) |
| GR (1) | GR3005324T3 (es) |
| PT (1) | PT90759B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026116B1 (en) | 1996-04-04 | 2006-04-11 | Bio-Rad Laboratories, Inc. | Polymorphisms in the region of the human hemochromatosis gene |
| US6140305A (en) | 1996-04-04 | 2000-10-31 | Bio-Rad Laboratories, Inc. | Hereditary hemochromatosis gene products |
| US6849399B1 (en) | 1996-05-23 | 2005-02-01 | Bio-Rad Laboratories, Inc. | Methods and compositions for diagnosis and treatment of iron misregulation diseases |
| ATE335759T1 (de) | 1997-06-13 | 2006-09-15 | Bio Rad Laboratories | Verfahren und zusammensetzungen für die diagnose und die behandlung von krankheiten, die mit eisenüberschuss oder eisenmangel assoziiert sind. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684482A (en) * | 1984-01-26 | 1987-08-04 | Oral-D (L.P.) | Orally effective ion chelators |
| EP0207097B1 (de) * | 1984-12-19 | 1990-08-08 | Ciba-Geigy Ag | Neue kohlensäureester |
| US4940811A (en) * | 1986-12-09 | 1990-07-10 | Ciba-Geigy Corporation | N,N-disubstituted ureas and processes for their manufacture |
| MX12394A (es) * | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | Procedimiento par la obtencion de carbamatos de polietilenglicol. |
-
1989
- 1989-05-30 ES ES198989810405T patent/ES2042061T3/es not_active Expired - Lifetime
- 1989-05-30 AT AT89810405T patent/ATE77368T1/de not_active IP Right Cessation
- 1989-05-30 EP EP89810405A patent/EP0346281B1/de not_active Expired - Lifetime
- 1989-05-30 DE DE8989810405T patent/DE58901673D1/de not_active Expired - Lifetime
- 1989-06-06 PT PT90759A patent/PT90759B/pt not_active IP Right Cessation
- 1989-06-07 DK DK278689A patent/DK278689A/da not_active Application Discontinuation
- 1989-06-07 JP JP1143187A patent/JPH0242052A/ja active Pending
-
1992
- 1992-07-31 GR GR920401272T patent/GR3005324T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT90759A (pt) | 1989-12-29 |
| GR3005324T3 (es) | 1993-05-24 |
| JPH0242052A (ja) | 1990-02-13 |
| DK278689D0 (da) | 1989-06-07 |
| EP0346281A1 (de) | 1989-12-13 |
| DE58901673D1 (de) | 1992-07-23 |
| ATE77368T1 (de) | 1992-07-15 |
| DK278689A (da) | 1989-12-09 |
| PT90759B (pt) | 1994-10-31 |
| EP0346281B1 (de) | 1992-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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