ES2042528T3 - Un procedimiento de preparacion de una composicion para potenciar la penetracion por membranas de al menos un agente sistematicamente activo. - Google Patents

Un procedimiento de preparacion de una composicion para potenciar la penetracion por membranas de al menos un agente sistematicamente activo.

Info

Publication number
ES2042528T3
ES2042528T3 ES87116755T ES87116755T ES2042528T3 ES 2042528 T3 ES2042528 T3 ES 2042528T3 ES 87116755 T ES87116755 T ES 87116755T ES 87116755 T ES87116755 T ES 87116755T ES 2042528 T3 ES2042528 T3 ES 2042528T3
Authority
ES
Spain
Prior art keywords
carbon atoms
membrane penetration
preparing
procedure
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87116755T
Other languages
English (en)
Inventor
James V Peck
Gevork Nmi Minaskanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitby Research Inc
Original Assignee
Whitby Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitby Research Inc filed Critical Whitby Research Inc
Application granted granted Critical
Publication of ES2042528T3 publication Critical patent/ES2042528T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/402—Amides imides, sulfamic acids
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/44—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using insoluble pigments or auxiliary substances, e.g. binders
    • D06P1/64—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using insoluble pigments or auxiliary substances, e.g. binders using compositions containing low-molecular-weight organic compounds without sulfate or sulfonate groups
    • D06P1/642—Compounds containing nitrogen
    • D06P1/649—Compounds containing carbonamide, thiocarbonamide or guanyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA ADMINISTRAR AGENTES ACTIVOS SISTEMICAMENTE INCLUYENDO AGENTES TERAPEUTICOS, A TRAVES DE LA PIEL O DE LAS MUCOSAS, EN HOMBRES Y ANIMALES EN UN DISPOSITIVO O FORMULACION TRANSDERMICOS QUE CONSISTE EN ADMINISTRAR TOPICAMENTE CON DICHO AGENTE SISTEMICO, UNA CANTIDAD EFECTIVA DE UN MEJORADOR DE LA PENETRACION EN MEMBRANAS, DE FORMULA ESTRUCTURAL (I), EN LA QUE R1 Y R2 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO FORMADO POR RADICALES ALQUILO Y CICLOALQUILO DE 1 A 20 ATOMOS DE C, Y R SE SELECCIONA DEL GRUPO FORMADO POR RADICALES ALQUILO Y CICLOALQUILO DE 1 A 30 C, CON LA CONDICION DE QUE EL NUMERO TOTAL DE ATOMOS DE C EN DICHOS COMPUESTOS SEA 15 O MAYOR Y EL NUMERO TOTAL DE ATOMOS DE C EN R1 Y R2 SEA 5 O MAYOR.
ES87116755T 1986-11-19 1987-11-13 Un procedimiento de preparacion de una composicion para potenciar la penetracion por membranas de al menos un agente sistematicamente activo. Expired - Lifetime ES2042528T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/932,651 US4808414A (en) 1986-09-29 1986-11-19 Amide penetration enhancers for transdermal delivery of systemic agents

Publications (1)

Publication Number Publication Date
ES2042528T3 true ES2042528T3 (es) 1993-12-16

Family

ID=25462662

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87116755T Expired - Lifetime ES2042528T3 (es) 1986-11-19 1987-11-13 Un procedimiento de preparacion de una composicion para potenciar la penetracion por membranas de al menos un agente sistematicamente activo.

Country Status (9)

Country Link
US (1) US4808414A (es)
EP (1) EP0268220B1 (es)
JP (1) JPS63139136A (es)
KR (1) KR880005945A (es)
AT (1) ATE76303T1 (es)
AU (1) AU624573B2 (es)
DE (1) DE3779260D1 (es)
ES (1) ES2042528T3 (es)
GR (1) GR3005442T3 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973579A (en) * 1985-06-28 1990-11-27 Merck & Co., Inc. Enhancment of absorption of drugs from gastrointestinal tract using choline ester salts
US4902676A (en) * 1986-09-29 1990-02-20 Nelson Research & Development Co. Compositions comprising N,N-dialkylalkanamides
DE3778833D1 (de) * 1986-11-19 1992-06-11 Whitby Research Inc Penetrationsverbesserer fuer die transdermale verabreichung von systemisch wirksamen arzneimitteln.
US5472946A (en) * 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
US5234959A (en) * 1988-04-08 1993-08-10 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US4927626A (en) * 1988-10-28 1990-05-22 Devillez Richard L Method for enhancement of unguis growth
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
WO1991005529A1 (en) * 1989-10-13 1991-05-02 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
NZ244862A (en) * 1991-10-23 1995-07-26 Block Drug Co Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent
JP3202777B2 (ja) * 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
TW224048B (es) * 1992-03-30 1994-05-21 Hoechst Roussel Pharma
ATE285212T1 (de) * 1993-10-07 2005-01-15 Odontex Inc Absorptionsförderer für topische pharmazeutische formulierungen
EP0745389A4 (en) * 1994-02-18 1998-01-14 Inst Advanced Skin Res Inc AGENT FOR TOPICAL APPLICATION
US6414028B1 (en) 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US6147102A (en) * 1999-10-26 2000-11-14 Curatek Pharmaceuticals Holding, Inc. Clonidine preparations
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US20040048779A1 (en) * 2002-05-06 2004-03-11 Erwin Schollmayer Use of rotigotine for treating the restless leg syndrome
ATE295726T1 (de) * 2002-12-02 2005-06-15 Sanol Arznei Schwarz Gmbh Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese
US8252320B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
US8246977B2 (en) 2004-10-21 2012-08-21 Durect Corporation Transdermal delivery systems
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
EP2334176A4 (en) 2008-09-27 2012-05-02 Taraxos Inc TOPICAL FORMULATIONS FOR THE TREATMENT OF NERVE DISEASES
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
AU2020315758B2 (en) 2019-07-16 2024-08-01 Donaghys Limited Transdermal solvent system and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954966A (en) * 1970-06-08 1976-05-04 Ceskoslovenska Akademie Ved Infusion solutions and method of manufacturing same
NL7214924A (es) * 1971-11-09 1973-05-11
GB1421743A (en) * 1972-04-18 1976-01-21 Wilkinson Sword Ltd Ingestible topical and other compositions
GB1427744A (en) * 1973-05-11 1976-03-10 Whitlock Inc Protective wrapping for an elongate member
DE2947648A1 (de) * 1979-11-27 1981-08-06 C.F. Spiess & Sohn GmbH & Co, 6719 Kleinkarlbach Verwendung tertiaerer heterocyclischer amine als potenzierungsmittel fuer insektizide
DE3009546A1 (de) * 1980-03-13 1981-09-24 Henkel KGaA, 4000 Düsseldorf Desodorierende kosmetische zusammensetzungen
US4590190A (en) * 1983-07-01 1986-05-20 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4743588A (en) * 1984-06-13 1988-05-10 Allergan Pharmaceuticals, Inc. Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents
US4680172A (en) * 1985-03-05 1987-07-14 Ciba-Geigy Corporation Devices and methods for treating memory impairment
CH666621A5 (de) * 1986-06-27 1988-08-15 Ciba Geigy Ag Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung.
US4902676A (en) * 1986-09-29 1990-02-20 Nelson Research & Development Co. Compositions comprising N,N-dialkylalkanamides

Also Published As

Publication number Publication date
EP0268220A2 (en) 1988-05-25
AU8132687A (en) 1988-05-26
US4808414A (en) 1989-02-28
EP0268220B1 (en) 1992-05-20
ATE76303T1 (de) 1992-06-15
DE3779260D1 (de) 1992-06-25
EP0268220A3 (en) 1988-09-21
JPS63139136A (ja) 1988-06-10
AU624573B2 (en) 1992-06-18
GR3005442T3 (es) 1993-05-24
KR880005945A (ko) 1988-07-21

Similar Documents

Publication Publication Date Title
ES2042528T3 (es) Un procedimiento de preparacion de una composicion para potenciar la penetracion por membranas de al menos un agente sistematicamente activo.
DE3382616D1 (de) Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe.
EP0336880A3 (de) Verwendung von topisch applizierbaren Präparaten zur Behandlung der Altershaut
ES2149338T3 (es) Utilizacion de compuestos que liberan oxido nitrico para la fabricacion de un medicamento destinado al tratamiento de lesiones por reperfusion isquemica.
EP0164998A3 (en) Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents
KR900701282A (ko) 심장 또는 뇌의 허혈성 질환의 치료, 예방제
ES2133324T3 (es) Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y metodos de uso.
ATE84045T1 (de) Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
ATE14076T1 (de) Galenische zubereitung.
KR950016760A (ko) 치질 치료제
ES2134237T3 (es) Composiciones farmaceuticas que contienen acido ursodesoxicolico.
ES2038154T3 (es) Un procedimiento para preparar una composicion para potenciar la penetracion de membranas de al menos un agente sistematicamente activo.
SE8101374L (sv) Kompositioner innehallande n,n-dietyl-m-toluamid
ES2036560T3 (es) Un metodo para preparar una composicion sinergicamente activa para el tratamiento de hipertension.
ATE34662T1 (de) Derivate der benzoesaeure, herstellungsverfahren und anwendung in desinfizierenden und konservierenden arzneimitteln.
KR900701278A (ko) 바이러스 감염 치료용 담즙산
ES2118255T3 (es) Agente para uso como antiirritante.
ES2032797T3 (es) Agente terapeutico para el tratamiento de la enfermedad ulcera peptica.
PT985414E (pt) Metodo de tratamento de glaucoma e retinopatia isquemica
ES2058097T3 (es) Agente antibacterial para su uso en mamiferos y que comprende derivados de cefalosporina como ingrediente activo.
EP0335446A3 (en) Agents for treating neoplasms
HK8994A (en) Medicament for treatment of pregnancy-induced hypertension
KR900016130A (ko) 2-피리딜메틸티오 유도체 및 궤양 치료제
ES2064382T3 (es) Agente para el tratamiento de la enfermedad de raynaud.
MX9800603A (es) Uso de la ipriflavona para reducir el numero de celulas cd8+.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 268220

Country of ref document: ES