ES2043781T3 - Un procedimiento para la preparacion de nuevos derivados de 2beta-morfolino-androstano. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 2beta-morfolino-androstano.

Info

Publication number
ES2043781T3
ES2043781T3 ES88200621T ES88200621T ES2043781T3 ES 2043781 T3 ES2043781 T3 ES 2043781T3 ES 88200621 T ES88200621 T ES 88200621T ES 88200621 T ES88200621 T ES 88200621T ES 2043781 T3 ES2043781 T3 ES 2043781T3
Authority
ES
Spain
Prior art keywords
compounds
preparation
androstano
morfolino
2beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88200621T
Other languages
English (en)
Inventor
David Samuel Savage
Thomas Sleig
Ian Graig Carlyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2043781T3 publication Critical patent/ES2043781T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Underground Structures, Protecting, Testing And Restoring Foundations (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA (I) DONDE R1 ES UN GRUPO ACILO OPCIONALMENTE SUSTITUIDO QUE TIENE DE 1 A 12 ATOMOS DE C, R2 ES UN GRUPO ACILO QUE TIENE DE 1 A 12 ATOMOS DE C Y R3 ES C, N-CH3 O UN ENLACE DIRECTO Y COMPUESTOS DE AMONIO MONO O BISCUATERNARIOS DE LOS MISMOS Y SALES POR ADICION DE ACIDO DE LOS COMPUESTOS DE AMONIO NO CUATERNARIO O MONOCUATERNARIOS. PROCEDIMIENTOS PARA LA PREPARACION DE ESTOS COMPUESTOS. COMPOSICIONES QUE CONTIENEN AL MENOS UNA DE LOS ANTERIORES COMPUESTOS COMO INGREDIENTE ACTIVO. LOS COMPUESTOS SON AGENTES FAVORECEDORES DEL BLOQUEO NEUROMUSCULAR.
ES88200621T 1987-04-14 1988-04-05 Un procedimiento para la preparacion de nuevos derivados de 2beta-morfolino-androstano. Expired - Lifetime ES2043781T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878708886A GB8708886D0 (en) 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives

Publications (1)

Publication Number Publication Date
ES2043781T3 true ES2043781T3 (es) 1994-01-01

Family

ID=10615781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88200621T Expired - Lifetime ES2043781T3 (es) 1987-04-14 1988-04-05 Un procedimiento para la preparacion de nuevos derivados de 2beta-morfolino-androstano.

Country Status (19)

Country Link
US (1) US4894369A (es)
EP (1) EP0287150B1 (es)
JP (1) JPH0753751B2 (es)
KR (2) KR0130208B1 (es)
AT (1) ATE79631T1 (es)
AU (1) AU608313B2 (es)
CA (1) CA1291117C (es)
DE (2) DE3873803T2 (es)
DK (1) DK174743B1 (es)
ES (1) ES2043781T3 (es)
FI (1) FI89057C (es)
GB (1) GB8708886D0 (es)
GR (1) GR3006275T3 (es)
HU (1) HU198738B (es)
IE (1) IE63672B1 (es)
NL (1) NL940010I2 (es)
NZ (1) NZ224228A (es)
PT (1) PT87250B (es)
ZA (1) ZA882481B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
WO2005068487A2 (en) * 2004-01-15 2005-07-28 Chemagis Ltd. Processes for the preparation of rocuronium bromide and intermediates thereof
US20060058276A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for the preparation and purification of rocuronium bromide
US20060058275A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for preparing stabilized, highly pure rocuronium bromide
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
CN101687905A (zh) * 2005-09-13 2010-03-31 西科尔公司 纯罗库溴铵
GB2445746A (en) * 2007-01-17 2008-07-23 Texcontor Ets Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying
CN101125878B (zh) * 2007-09-30 2011-01-12 浙江仙琚制药股份有限公司 甾体类肌松药物罗库溴铵的制备方法
CN101863948B (zh) * 2009-04-17 2013-07-24 重庆医药工业研究院有限责任公司 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法
CN101824066B (zh) * 2010-04-08 2012-06-13 浙江仙琚制药股份有限公司 制备罗库溴铵中间体化合物结晶物的方法
CN103119051B (zh) * 2011-01-26 2015-09-23 浙江华海药业股份有限公司 罗库溴铵的制备方法
EP2703408B1 (en) 2011-04-25 2015-08-26 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for purifying rocuronium bromide
CN110251459A (zh) 2013-07-01 2019-09-20 丸石制药株式会社 改善了血管痛的罗库铵制剂及其制造方法以及使用该罗库铵制剂的血管痛的抑制、缓和方法
CN105566433A (zh) * 2016-01-15 2016-05-11 安徽悦康凯悦制药有限公司 一种罗库溴铵的生产工艺
CN108570090B (zh) * 2018-05-25 2021-02-02 江苏盈科生物制药有限公司 一种高纯度罗库溴铵的制备方法
CN110734468B (zh) 2018-07-20 2021-04-16 济南高德医药科技有限公司 罗库溴铵粗品的精制方法
CN110240624B (zh) * 2019-08-01 2020-06-09 天津红日药业股份有限公司 一种雄甾烷衍生物及其制备方法与应用
CN111057122B (zh) * 2019-12-25 2021-04-30 武汉华龙生物制药有限公司 一种罗库溴铵的制备方法
CN115160397B (zh) * 2020-09-29 2023-08-01 天津红日药业股份有限公司 雄甾烷衍生物及其制备方法与应用
WO2022078483A1 (zh) * 2020-10-15 2022-04-21 江苏恩华络康药物研发有限公司 甾体季铵化合物及其制备方法、制剂和用途
CN114088842B (zh) * 2021-11-19 2023-03-21 江苏正济药业股份有限公司 一种罗库溴铵中间体及杂质的检测方法
CN116925171B (zh) * 2023-07-10 2025-06-27 时森海(杭州)医药科技有限公司 含环丙甲基甾体类季铵盐化合物、中间体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes

Also Published As

Publication number Publication date
EP0287150B1 (en) 1992-08-19
ATE79631T1 (de) 1992-09-15
KR880012632A (ko) 1988-11-28
JPH0753751B2 (ja) 1995-06-07
GR3006275T3 (es) 1993-06-21
KR19980078895A (ko) 1998-11-25
PT87250B (pt) 1992-08-31
DE19575040I2 (de) 2003-09-18
JPS63277693A (ja) 1988-11-15
US4894369A (en) 1990-01-16
HU198738B (en) 1989-11-28
IE63672B1 (en) 1995-05-31
DK202888A (da) 1988-10-15
NL940010I1 (nl) 1994-07-18
FI89057C (fi) 1993-08-10
DK202888D0 (da) 1988-04-13
NL940010I2 (nl) 1997-10-01
CA1291117C (en) 1991-10-22
EP0287150A1 (en) 1988-10-19
NZ224228A (en) 1990-03-27
KR0130208B1 (ko) 1998-04-03
DK174743B1 (da) 2003-10-13
GB8708886D0 (en) 1987-05-20
DE3873803T2 (de) 1993-06-24
FI881707A0 (fi) 1988-04-13
AU608313B2 (en) 1991-03-28
PT87250A (pt) 1988-05-01
HUT47595A (en) 1989-03-28
IE881017L (en) 1988-10-14
ZA882481B (en) 1988-09-29
DE3873803D1 (de) 1992-09-24
AU1457088A (en) 1988-10-20
FI89057B (fi) 1993-04-30
FI881707A7 (fi) 1988-10-15
KR100221116B1 (ko) 1999-10-01

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